Sensors and Actuators B Chemical, Год журнала: 2022, Номер 357, С. 131429 - 131429
Опубликована: Янв. 19, 2022
Язык: Английский
ACS Nano, Год журнала: 2024, Номер 18(19), С. 12049 - 12095
Опубликована: Май 2, 2024
Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.
Язык: Английский
Процитировано
61
Nano Today, Год журнала: 2023, Номер 48, С. 101755 - 101755
Опубликована: Янв. 14, 2023
Язык: Английский
Процитировано
60
Small, Год журнала: 2023, Номер 19(11)
Опубликована: Янв. 17, 2023
Abstract On accounts of the advantages inherent high stability, ease preparation and superior catalytic activities, nanozymes have attracted tremendous potential in diverse biomedical applications as alternatives to natural enzymes. Optimizing activity is significant for widening boosting into practical level. As research regulation strategies boosting, it essential timely review, summarize, analyze advances structure–activity relationships further inspiring ingenious this prosperous area. Herein, methods recent 5 years are systematically summarized, including size morphology, doping, vacancy, surface modification, hybridization, followed by a discussion latest consisting biosensing, antibacterial, tumor therapy. Finally, challenges opportunities rapidly developing field presented more infant yet promising
Язык: Английский
Процитировано
58
Advanced Science, Год журнала: 2023, Номер 10(13)
Опубликована: Фев. 27, 2023
With the threat posed by drug-resistant pathogenic bacteria, developing non-antibiotic strategies for eradicating clinically prevalent superbugs remains challenging. Ferroptosis is a newly discovered form of regulated cell death that can overcome drug resistance. Emerging evidence shows potential triggering ferroptosis-like antibacterial therapy, but direct delivery iron species inefficient and may cause detrimental effects. Herein, an effective strategy to induce bacterial nonferrous coordinating single-atom metal sites (e.g., Ir Ru) into sp
Язык: Английский
Процитировано
53
BMEMat, Год журнала: 2023, Номер unknown
Опубликована: Сен. 19, 2023
Abstract Nanozymes have emerged as a promising alternative to natural enzymes, effectively addressing enzymes' inherent limitation. Versatility and potential applications of nanozyme span across various fields, with catalytic tumor therapy being one prominent area. This has sparked significant interest exploration in the utilization nanozymes for targeted cancer treatment. Recent advancements interdisciplinary research, nanotechnology, biotechnology, technology led emergence multi‐metallic‐based nanozymes, which exhibit tremendous further development. review focuses on investigating synergistic effects aiming enhance our understanding their activities facilitate broader applications. We comprehensively survey remarkable achievements synthesis, mechanisms, latest therapy. Furthermore, we identify current limitations prospects development new materials application novel technologies, along challenges associated underscores significance emphasizes need continued well impact realization breakthroughs
Язык: Английский
Процитировано
50
Advanced Healthcare Materials, Год журнала: 2023, Номер 12(25)
Опубликована: Июль 1, 2023
Nanomaterials that mimic the catalytic activity of natural enzymes in complex biological environment human body are called nanozymes. Recently, nanozyme systems have been reported with diagnostic, imaging, and/or therapeutic capabilities. Smart nanozymes strategically exploit tumor microenvironment (TME) by situ generation reactive species or modulation TME itself to result effective cancer therapy. This topical review focuses on such smart for diagnosis, and therapy modalities enhanced effects. The dominant factors guide rational design synthesis include an understanding dynamic TME, structure-activity relationships, surface chemistry imparting selectivity, site-specific therapy, stimulus-responsive activity. article presents a comprehensive analysis subject including diverse mechanisms different types systems, overview synergistic therapies. strategic application treatment can well be game changer future oncology. Moreover, recent developments may pave way deployment into other healthcare challenges, as genetic diseases, immune disorders, ageing.
Язык: Английский
Процитировано
49
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 260, С. 129374 - 129374
Опубликована: Янв. 18, 2024
Язык: Английский
Процитировано
23
Analytical Chemistry, Год журнала: 2024, Номер 96(6), С. 2610 - 2619
Опубликована: Фев. 2, 2024
Laccase, a member of the copper oxidase family, has been used as green catalyst in environmental and biochemical industries. However, laccase nanoenzymes are limited to materials with active site, noncopper have scarcely reported. In this study, inspired by multiple sites natural redox Cu2+/Cu+ electron transfer pathway, novel nitrogen/nickel single-atom nanoenzyme (N/Ni SAE) high laccase-like activity was prepared inducing Ni dopamine precipitation through controllable water/ethanol interface reaction. Compared that laccase, simulated N/Ni SAE exhibited excellent stability reusability. The higher efficiency toward degradation 2,4-dichlorophenol, hydroquinone, bisphenol A, p-aminobenzene. addition, sensitive electrochemical biosensor constructed leveraging SAE; sensor offered unique advantages terms catalytic activity, selectivity, stability, repeatability. Its detection ranges for quercetin were 0.01–0.1 1.0–100 μM, limit 3.4 nM. It also successfully quantitative fruit juices. Therefore, biomimetic study promote development new strategy various bioactive molecules show great potential practical applications.
Язык: Английский
Процитировано
20
Coordination Chemistry Reviews, Год журнала: 2024, Номер 522, С. 216205 - 216205
Опубликована: Сен. 11, 2024
Язык: Английский
Процитировано
18
Chemical Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.
Язык: Английский
Процитировано
5