Nanotechnology,
Год журнала:
2024,
Номер
35(36), С. 362006 - 362006
Опубликована: Июнь 12, 2024
Reactive
oxygen
species
(ROS)
play
important
roles
in
regulating
various
physiological
functions
the
human
body,
however,
excessive
ROS
can
cause
serious
damage
to
considering
limitations
of
natural
enzymes
as
scavengers
development
better
materials
for
scavenging
is
great
significance
biomedical
field,
and
nanozymes,
a
kind
nanomaterials
which
show
activity
enzymes.
Have
good
potential
area
scavenging.
Metal-organic
frameworks
(MOFs),
are
porous
crystalline
with
periodic
network
structure
composed
metal
nodes
organic
ligands,
have
been
developed
variety
active
nanozymes
including
catalase-like,
superoxide
dismutase-like,
glutathione
peroxidase-like
due
adjustability
sites,
structural
diversity,
excellent
biocompatibility,
they
shown
wide
range
applications
prospects.
In
present
review,
we
first
introduce
three
representative
methods
detection
relevant
enzyme-like
activities
mechanisms
clearance
discussed,
meanwhile,
systematically
summarize
progress
research
on
MOF-based
design
strategy,
mechanism
action,
medical
application,
etc.
Finally,
current
challenges
summarized,
future
direction
anticipated.
We
hope
that
this
review
contribute
field
related
ROS.
Advanced Materials,
Год журнала:
2023,
Номер
36(10)
Опубликована: Апрель 5, 2023
Metabolism
is
the
sum
of
enzyme-dependent
chemical
reactions,
which
produces
energy
in
catabolic
process
and
synthesizes
biomass
anabolic
process,
exhibiting
high
similarity
mammalian
cell,
microbial
plant
cell.
Consequently,
loss
or
gain
metabolic
enzyme
activity
greatly
affects
cellular
metabolism.
Nanozymes,
as
emerging
mimics
with
diverse
functions
adjustable
catalytic
activities,
have
shown
attractive
potential
for
regulation.
Although
basic
tasks
are
highly
similar
cells
from
different
species,
concrete
pathway
varies
intracellular
structure
species.
Here,
metabolism
living
organisms
described
similarities
differences
pathways
among
mammalian,
microbial,
regulation
mechanism
discussed.
The
recent
progress
on
mainly
including
nutrient
uptake
utilization,
production,
accompanied
redox
reactions
by
kinds
oxidoreductases
their
applications
field
disease
therapy,
antimicrobial
sustainable
agriculture
systematically
reviewed.
Furthermore,
prospects
challenges
nanozymes
regulating
cell
also
discussed,
broaden
application
scenarios.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Фев. 6, 2024
Inflammatory
skin
disorders
can
cause
chronic
scarring
and
functional
impairments,
posing
a
significant
burden
on
patients
the
healthcare
system.
Conventional
therapies,
such
as
corticosteroids
nonsteroidal
anti-inflammatory
drugs,
are
limited
in
efficacy
associated
with
adverse
effects.
Recently,
nanozyme
(NZ)-based
hydrogels
have
shown
great
promise
addressing
these
challenges.
NZ-based
possess
unique
therapeutic
abilities
by
combining
benefits
of
redox
nanomaterials
enzymatic
activity
water-retaining
capacity
hydrogels.
The
multifaceted
effects
include
scavenging
reactive
oxygen
species
other
inflammatory
mediators
modulating
immune
responses
toward
pro-regenerative
environment
enhancing
regenerative
potential
triggering
cell
migration
differentiation.
This
review
highlights
current
state
art
NZ-engineered
(NZ@hydrogels)
for
regeneration
applications.
It
also
discusses
underlying
chemo-mechano-biological
mechanisms
behind
their
effectiveness.
Additionally,
challenges
future
directions
this
ground,
particularly
clinical
translation,
addressed.
insights
provided
aid
design
engineering
novel
hydrogels,
offering
new
possibilities
targeted
personalized
skin-care
therapies.
CsPbX3
perovskite
nanocrystal
(NC)
is
considered
as
an
excellent
optical
material
and
widely
applied
in
optoelectronics.
However,
its
poor
water
stability
impedes
study
enzyme-like
activity,
further
inhibits
application
biomimetic
cascade
catalysis.
Herein,
for
the
first
time,
oxidase-like
ascorbate
activities
of
amphiphilic
polymer
capped
are
demonstrated,
catalytic
mechanism
explored.
Furthermore,
all-nanozyme
system
(multifunctional
CsPbBr3
@Zr-metal
organic
framework
(Zr-MOF)
Prussian
blue
peroxidase-like
nanozyme)
constructed
with
a
portable
paper-based
device
realizing
dual-mode
(ratiometric
fluorescence
colorimetric)
detection
ascorbic
acid
point-of-care
(POC)
fashion.
This
report
on
utilization
all-inorganic
NC
catalysis,
which
opens
new
avenue
POC
clinical
disease
diagnosis.
Abstract
Nanozymes
show
great
promise
in
enhancing
disease
biomarker
sensing
by
leveraging
their
physicochemical
properties
and
enzymatic
activities.
These
qualities
facilitate
signal
amplification
matrix
effects
reduction,
thus
boosting
performance.
In
this
review,
recent
studies
from
the
last
five
years,
concentrating
on
detection
improvement
through
nanozyme‐based
biosensing
are
examined.
This
enhancement
primarily
involves
modulations
of
size,
morphology,
doping,
modification,
electromagnetic
mechanisms,
electron
conduction
efficiency,
surface
plasmon
resonance
nanozymes
for
increased
sensitivity.
addition,
a
comprehensive
description
synthesis
tuning
strategies
employed
has
been
provided.
includes
detailed
elucidation
catalytic
mechanisms
alignment
with
fundamental
principles
enhanced
technology,
accompanied
presentation
quantitatively
analyzed
results.
Moreover,
diverse
applications
strip
sensing,
colorimetric
electrochemical
surface‐enhanced
Raman
scattering
have
outlined.
Additionally,
limitations,
challenges,
corresponding
recommendations
concerning
application
summarized.
Furthermore,
insights
offered
into
future
development
outlook
biosensing.
review
aims
to
serve
not
only
as
reference
sensitivity
biosensors
but
also
catalyst
exploring
nanozyme
broader
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15493 - 15493
Опубликована: Окт. 23, 2023
Bacterial
antibiotic
resistance,
especially
the
emergence
of
multidrug-resistant
(MDR)
strains,
urgently
requires
development
effective
treatment
strategies.
It
is
always
interest
to
delve
into
mechanisms
resistance
current
antibiotics
and
target
them
promote
efficacy
existing
antibiotics.
In
recent
years,
non-antibiotic
compounds
have
played
an
important
auxiliary
role
in
improving
promoting
drug-resistant
bacteria.
The
combination
with
considered
a
promising
strategy
against
MDR
this
review,
we
first
briefly
summarize
main
addition,
propose
several
strategies
enhance
action
based
on
mechanisms.
Then,
research
progress
that
can
antibiotic-resistant
bacteria
through
different
years
also
summarized.
Finally,
prospects
challenges
these
are
discussed.
Abstract
The
clinical
application
of
oncology
therapy
is
hampered
by
high
glutathione
concentrations,
hypoxia,
and
inefficient
activation
cell
death
mechanisms
in
cancer
cells.
In
this
study,
Fe
Mo
bimetallic
sulfide
nanomaterial
(FeS
2
@MoS
)
based
on
metal‐organic
framework
structure
rationally
prepared
with
peroxidase
(POD)‐,
catalase
(CAT)‐,
superoxide
dismutase
(SOD)‐like
activities
depletion
ability,
which
can
confer
versatility
for
treating
tumors
mending
wounds.
the
lesion
area,
FeS
SOD‐like
activity
facilitate
transformation
anions
(O
−
to
hydrogen
peroxide
(H
O
),
then
resulting
H
serves
as
a
substrate
Fenton
reaction
FMS
produce
highly
toxic
hydroxyl
radicals
(
∙
OH).
Simultaneously,
has
an
ability
deplete
(GSH)
catalyze
decomposition
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
curb
regeneration
GSH
from
source.
Thus
it
realize
effective
tumor
elimination
through
synergistic
apoptosis‐ferroptosis
strategy.
Based
alteration
system,
free
radical
production,
alleviation
hypoxia
microenvironment,
NPS
not
only
significantly
inhibit
vivo
vitro,
but
also
multidrug‐resistant
bacteria
hasten
wound
healing.
It
may
open
door
development
cascade
nanoplatforms
treatment
overcoming
infection.
