Ageing Research Reviews,
Год журнала:
2023,
Номер
92, С. 102094 - 102094
Опубликована: Окт. 18, 2023
As
a
global
public
health
problem,
low
back
pain
(LBP)
caused
by
intervertebral
disc
degeneration
(IDD)
seriously
affects
patients'
quality
of
life.
In
addition,
the
prevalence
IDD
tends
to
be
younger,
which
brings
huge
burden
individuals
and
society
economically.
Current
treatments
do
not
delay
or
reverse
progression
IDD.
The
emergence
biologic
therapies
has
brought
new
hope
for
treatment
Among
them,
extracellular
vesicles
(EVs),
as
nanoscale
bioactive
substances
that
mediate
cellular
communication,
have
now
produced
many
surprising
results
in
research
This
article
reviews
mechanisms
roles
EVs
delaying
describes
prospects
challenges
EVs.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 8, 2022
Low
back
pain
has
been
found
as
a
major
cause
of
global
disease
burden
and
disability.
Intervertebral
disc
degeneration
is
recognized
the
vital
factor
causing
low
pain.
complex
mechanism
cannot
be
avoided.
Traditional
strategies
for
treatment
intervertebral
meet
needs
regeneration,
so
novel
methods
are
urgently
required.
Exosomes
refer
to
extracellular
vesicles
that
can
released
by
most
cells,
play
roles
in
intercellular
material
transport
information
transmission.
MicroRNAs
have
identified
essential
components
exosomes,
which
selectively
ingested
exosomes
delivered
receptor
cells
regulation
physiological
activities
functions
cells.
Existing
studies
progressively
focused
on
role
exosomal
microRNAs
degeneration.
The
focus
this
paper
placed
changes
microenvironment
during
biogenesis
action
microRNAs.
research
results
deficiencies
apoptosis,
matrix
homeostasis,
inflammatory
response,
oxidative
stress,
angiogenesis
primarily
investigated.
aim
identify
latest
results,
potential
applications
challenges
emerging
strategy.
Frontiers in Cell and Developmental Biology,
Год журнала:
2023,
Номер
11
Опубликована: Окт. 23, 2023
Osteoimmunology
is
a
concept
involving
molecular
and
cellular
crosstalk
between
the
skeletal
immune
systems.
Toll-like
receptors
(TLRs)
are
widely
expressed
both
on
mesenchymal
stromal
cells
(MSCs),
hematopoietic
cells,
in
osteogenic
microenvironment
for
bone
development
or
repair.
TLRs
can
sense
exogenous
pathogen-associated
patterns
(PAMPs)
derived
from
microorganisms,
damage-associated
(DAMPs)
normal
subjected
to
injury,
inflammation,
cell
apoptosis
under
physiological
pathological
conditions.
Emerging
studies
reported
that
TLR
signaling
plays
an
important
role
remodeling
by
directly
impacting
MSC
differentiation
osteoimmunology.
However,
how
regulate
critical
remains
be
elucidated
promote
of
MSCs
new
formation
tissue
This
review
outlines
distinct
variants
various
tissues,
detailing
impact
pathway
activation
inhibition
differentiation.
It
also
elucidates
pathways’
interplay
with
osteoclasts,
extracellular
vesicles
(EVs)
MSCs.
Furthermore,
we
explore
biomaterial-based
guide
MSCs’
Therefore,
understanding
TLRs’
this
context
has
significant
implications
advancing
regeneration
repair
strategies.
Ageing Research Reviews,
Год журнала:
2023,
Номер
92, С. 102094 - 102094
Опубликована: Окт. 18, 2023
As
a
global
public
health
problem,
low
back
pain
(LBP)
caused
by
intervertebral
disc
degeneration
(IDD)
seriously
affects
patients'
quality
of
life.
In
addition,
the
prevalence
IDD
tends
to
be
younger,
which
brings
huge
burden
individuals
and
society
economically.
Current
treatments
do
not
delay
or
reverse
progression
IDD.
The
emergence
biologic
therapies
has
brought
new
hope
for
treatment
Among
them,
extracellular
vesicles
(EVs),
as
nanoscale
bioactive
substances
that
mediate
cellular
communication,
have
now
produced
many
surprising
results
in
research
This
article
reviews
mechanisms
roles
EVs
delaying
describes
prospects
challenges
EVs.
