Disclosure Behavior of Annual Reports of Listed Companies Under Digital Worship DOI
Xiaojing Xu

Springer eBooks, Год журнала: 2017, Номер unknown, С. 530 - 537

Опубликована: Июнь 28, 2017

Язык: Английский

Targeting ferroptosis: opportunities and challenges of mesenchymal stem cell therapy for type 1 diabetes mellitus DOI Creative Commons
Le Dai, Qing Wang

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 4, 2025

Abstract Type 1 diabetes mellitus (T1DM) is characterized by progressive β-cell death, leading to loss and insufficient insulin secretion. Mesenchymal stem cells (MSCs) transplantation currently one of the most promising methods for replacement therapy. However, recent studies have shown that ferroptosis not only key mechanisms but also reasons extensive cell death within a short period time after MSCs transplantation. Ferroptosis new type regulated (RCD) iron-dependent accumulation lipid peroxides. Due weak antioxidant capacity β-cells, they are susceptible cytotoxic stimuli such as oxidative stress (OS), therefore ferroptosis. Transplanted extremely perturbations in their microenvironment, especially OS, which can weaken induce through In pathophysiological process T1DM, large amount reactive oxygen species (ROS) produced, causing OS. Therefore, targeting may be way protect β-cells improve therapeutic effect This review reviews research related MSCs, summarizes developed strategies help inhibit study aims understand mechanism transplantation, emphasize importance protecting improving survival function transplanted provide direction therapy T1DM future.

Язык: Английский

Процитировано

0
Tert-butyl hydroperoxide induces ferroptosis of bone mesenchymal stem cells by repressing the prominin2/BACH1/ROS axis DOI

Yuzhu Xu,

Fan Pan,

Xuanfei Xu

и другие.

AJP Cell Physiology, Год журнала: 2023, Номер 325(5), С. C1212 - C1227

Опубликована: Сен. 18, 2023

Ferroptosis has been proven critical for survival following bone marrow mesenchymal stem cells (BMSCs) explantation. Suppression of ferroptosis in BMSCs will be a valid tactic to elevate the therapeutic potential engrafted BMSCs. Prominin2 is pentaspanin protein involved mediating iron efflux and thus modulates resistance ferroptosis, but its role tert-butyl hydroperoxide (TBHP)-induced remains elusive. We examined biological effect prominin2 vitro vivo by using cell proliferation assay, reactive oxygen species (ROS) examination, malondialdehyde glutathione (GSH) Western blot, quantitative reverse transcription-PCR, immunofluorescence staining gene expression inhibition activation, co-immunoprecipitation (CO-IP) radiographic analysis, histopathological analysis. Our study demonstrated that activity was impaired TBHP-induced ferroptosis. found PROM2 (encoding prominin2) activation delayed onset knockdown deteriorated course CO-IP, exerts antiferroptosis effects inhibiting BTB CNC homology 1 (BACH1) promotes ROS generation, potent antioxidant oxidative stress (OS)-induced including elevating BMSCs' rate enhancing GSH contents. with overexpression also partially progression intervertebral disk degeneration vivo, as illustrated less loss height lower histological scores. findings revealed mechanism prominin2/BACH1/ROS axis participates strengthening this promising maintain after

Язык: Английский

Процитировано

7
MiR-4465修饰的间质干细胞来源的小细胞外囊泡通过靶向LOXL2表达抑制肝纤维化的进展 DOI
Yanjin Wang, Yifei Chen,

Fuji Yang

и другие.

Journal of Zhejiang University SCIENCE B, Год журнала: 2024, Номер 25(7), С. 594 - 604

Опубликована: Май 17, 2024

Язык: Английский

Процитировано

2
人脐带间充质干细胞通过 IGF1R-CHK2-p53 信号轴减轻 2 型糖尿病雄性大鼠糖尿病肾病 DOI
Hao Zhang,

Xinshu Wang,

Bo Hu

и другие.

Journal of Zhejiang University SCIENCE B, Год журнала: 2024, Номер 25(7), С. 568 - 580

Опубликована: Июль 1, 2024

Язык: Английский

Процитировано

1
Olig2+ single-colony-derived cranial bone-marrow mesenchymal stem cells achieve improved regeneration in a cuprizone-induced demyelination mouse model DOI
Deqing Peng, Ruijie Lu,

Leyao Lü

и другие.

Journal of Zhejiang University SCIENCE B, Год журнала: 2024, Номер unknown

Опубликована: Сен. 25, 2024

Язык: Английский

Процитировано

0
Human umbilical cord mesenchymal stem cells restore chemotherapy-induced premature ovarian failure by inhibiting ferroptosis in vitro ovarian culture system DOI Creative Commons
Jiaqi Chen,

Zhuoying He,

Wenjuan Xu

и другие.

Reproductive Biology and Endocrinology, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 7, 2024

Mesenchymal stem cells (MSCs) have shown potential in repairing chemotherapy-induced premature ovarian failure (POF). However, challenges such as cell loss and immune phagocytosis post-transplantation hinder their application. Due to easy safe handling, vitro culture is widely available for drug screening, pathophysiological research, fertilization. MSCs could exhibit therapeutic capacity injury, avoid tissue system. Therefore, this study utilizes an system investigate the reparative of human umbilical cord mesenchymal (hUCMSCs) mechanism.

Язык: Английский

Процитировано

0
Disclosure Behavior of Annual Reports of Listed Companies Under Digital Worship DOI
Xiaojing Xu

Springer eBooks, Год журнала: 2017, Номер unknown, С. 530 - 537

Опубликована: Июнь 28, 2017

Язык: Английский

Процитировано

0