Advanced Materials,
Год журнала:
2023,
Номер
36(8)
Опубликована: Сен. 19, 2023
Abstract
Nanozymes,
as
one
of
the
most
efficient
reactive
oxygen
species
(ROS)‐scavenging
biomaterials,
are
receiving
wide
attention
in
promoting
diabetic
wound
healing.
Despite
recent
attempts
at
improving
catalytic
efficiency
Pt‐based
nanozymes
(e.g.,
PtCu,
best
systems),
they
still
display
quite
limited
ROS
scavenging
capacity
and
ROS‐dependent
antibacterial
effects
on
bacteria
or
immunocytes,
which
leads
to
uncontrolled
poor
Hence,
a
new
class
multifunctional
PtCuTe
nanosheets
with
excellent
catalytic,
ROS‐independent
antibacterial,
proangiogenic,
anti‐inflammatory,
immuno‐modulatory
properties
for
boosting
healing,
is
reported.
The
show
stronger
better
than
PtCu.
It
also
revealed
that
can
enhance
vascular
tube
formation,
stimulate
macrophage
polarization
toward
M2
phenotype
improve
fibroblast
mobility,
outperforming
conventional
Moreover,
promotes
crosstalk
between
different
cell
types
form
positive
feedback
loop.
Consequently,
stimulates
proregenerative
environment
relevant
populations
ensure
normal
tissue
repair.
Utilizing
mouse
model,
it
demonstrated
significantly
facilitated
regeneration
highly
vascularized
skin,
percentage
closure
being
over
90%
8th
day,
among
reported
comparable
biomaterials.
ACS Materials Letters,
Год журнала:
2023,
Номер
5(12), С. 3142 - 3155
Опубликована: Окт. 27, 2023
Antibacterial,
anti-inflammatory,
and
healing-promoting
treatment
of
chronically
infected
wounds
is
not
only
clinical
problems
to
be
solved
urgently
but
also
important
needs
related
people's
livelihood.
However,
multifunctional
hydrogel
dressings
with
highly
efficient
antibacterial,
wound
microenvironment
sensitive
drug
release
performance
still
remain
a
challenge.
In
this
work,
dressing
was
achieved
by
introducing
mussel-like
super
adhesion
catechol
groups
glucose/ROS-sensitive
dynamic
phenylboronester
bond
cross-linking
network,
which
endowed
the
excellent
injectable,
self-healing,
tissue
properties,
performance.
Additionally,
high-efficiency
photothermal
synergistic
antibacterial
TP@Ag
NPs
were
prepared
introduced
into
hydrogel.
The
glucose/ROS
responsive
borate
in
network
could
realize
NPs,
thereby
promoting
M2
polarization
achieve
an
anti-inflammatory
effect.
And
excess
reactive
oxygen
(ROS)
scavenged
effect
group
ROS-sensitive
Moreover,
biocompatibility
antioxidant
shown
hydrogels.
Finally,
fully
fill
adhere
irregular
through
injection
significantly
promote
diabetic
healing
vivo
sterilization,
ROS
scavenging
ability,
modulation
macrophage
reduce
inflammatory
response.
Thus,
it
illustrated
superiority
as
advanced
functional
for
healing.
Biomaterials Science,
Год журнала:
2024,
Номер
12(6), С. 1405 - 1424
Опубликована: Янв. 1, 2024
This
review
introduces
gallic-acid
hydrogels,
covering
their
crosslinking
mechanisms,
physicochemical
properties,
synthesis
methods,
and
biomedical
applications,
aiming
to
provide
inspiration
for
the
design
of
multifunctional
polyphenol
hydrogels.
