Food-derived tripeptide–copper self-healing hydrogel for infected wound healing

Biomaterials Research, Год журнала: 2025, Номер 29

Опубликована: Янв. 1, 2025

The field of infected wound management continues to face challenges, and traditional methods used cope with wounds include debridement, gauze coverage, medication, others. Currently, synthetic natural biomaterials are readily available today, enabling the creation new dressings that substantially enhance healing. Considerable attention is being paid hydrogels based on materials, which have good biocompatibility degradability properties, while exhibiting higher similarity extracellular matrix as compared materials. In this study, we extracted active ingredients oxidized konjac glucomannan (OKGM) fresh egg white (EW) from 2 foods, konjac, egg, respectively, formed a self-repairing hydrogel cross-linking Schiff base. Subsequently, peptide, glycyl-l-histidyl-l-lysine-Cu (GHK-Cu), was loaded, an all-natural composite dressing, EW/OKGM@GHK-Cu (GEK), developed. GEK hydrogel, both antibacterial anti-inflammatory plays hemostatic role by adhering tissues promoting neovascularization serves optimal dressing for skin regeneration. Taken together, derived food sources therefore constitute efficient cost-effective strategy managing healing significant potential clinical application transformation.

Язык: Английский

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Hydrogel inspired by "adobe" with antibacterial and antioxidant properties for diabetic wound healing

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101477 - 101477

Опубликована: Янв. 10, 2025

With the aging population, incidence of diabetes is increasing. Diabetes often leads to restricted neovascularization, antibiotic-resistant bacterial infections, reduced wound perfusion, and elevated reactive oxygen species, resulting in impaired microenvironments prolonged healing. Hydrogels are important tissue engineering materials for healing, known their high water content good biocompatibility. However, most hydrogels suffer from poor mechanical properties difficulty achieving sustained drug release, hindering clinical application. Inspired by incorporation fibers enhance "adobe," core-shell were introduced into hydrogel. This not only improves strength hydrogel but also enables possibility release. In this study, we first prepared with PLGA (poly(lactic-co-glycolic acid)) PCL (polycaprolactone). was loaded P2 (Parathyroid hormone-related peptides-2), developed our group, which promotes angiogenesis cell proliferation. We then designed a QTG (QCS/TA/Gel, quaternary ammonium chitosan/tannic acid/gelatin) hydrogel, incorporating anti-inflammatory celecoxib exhibits excellent antibacterial biocompatibility, along performance. demonstrates absorption swelling capabilities. early stages can absorb exudate, maintaining stability microenvironment. neovascularization collagen deposition, accelerating healing diabetic wounds, rate exceeding 95 % day 14. Overall, study provides promising strategy developing scaffolds

Язык: Английский

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Design and biofabrication of barnacle and spider silk protein decorated composite bacterial cellulose for diabetic wound healing

Carbohydrate Polymers, Год журнала: 2025, Номер 354, С. 123301 - 123301

Опубликована: Янв. 20, 2025

Язык: Английский

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Thermoresponsive in situ forming self-healing hydrogel dressings with pH/glucose dual responsive curcumin release for diabetic wound healing

Journal of Materials Science, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Язык: Английский

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Biosensors integrated within wearable devices for monitoring chronic wound status

APL Bioengineering, Год журнала: 2025, Номер 9(1)

Опубликована: Фев. 4, 2025

Slowly healing wounds significantly affect the life quality of patients in different ways, due to constant pain, unpleasant odor, reduced mobility up social isolation, and personal frustration. While remote wound management has become more widely accepted since COVID-19 pandemic, delayed treatment remains frequent results several related complications. As inappropriate notably diabetic foot ulcers is linked a high risk amputation, effective patient-centered manner important be implemented. The integration diagnostic devices into bandages under way, owing advancements materials science nanofabrication strategies as well innovation communication technologies together with machine learning data-driven assessment tools. Leveraging advanced analytical approaches around local pH, temperature, pressure, biomarker sensing expected facilitate adequate treatment. state-of-the-art time-resolved monitoring status by quantifying key physiological parameters biomarkers' concentration presented herewith. A special focus will given smart on-demand delivery capabilities for improved management.

Язык: Английский

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Multi-functional dressing with curcumin displays anti-inflammatory, antioxidant, angiogenic, and collagen regeneration effects in diabetic wound healing

Journal of Materials Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Язык: Английский

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Cost-effective and natural-inspired lotus root/GelMA scaffolds enhanced wound healing via ROS scavenging, angiogenesis and reepithelialization

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134496 - 134496

Опубликована: Авг. 10, 2024

Язык: Английский

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Emerging Technological Advancement for Chronic Wound Treatment and Their Role in Accelerating Wound Healing

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(11), С. 7101 - 7132

Опубликована: Окт. 28, 2024

Chronic wounds are a major healthcare burden and may severely affect the social, mental, economic status of patients. Any impairment in wound healing stages due to underlying factors leads prolonged time subsequently chronic wounds. Traditional approaches for treatment include dressing free local therapy, tissue engineering based scaffold therapies. However, traditional therapies need improvisation have been advanced through breakthrough technologies. The present review spans further gives an extensive account advancements Cutting edge technologies, such as 3D printing, which includes inkjet fused deposition modeling, digital light processing, extrusion-based microneedle array-based therapies, gene microRNAs (miRNAs) smart dressings real monitoring conditions assessment pH, temperature, oxygen, moisture, metabolites, their use planning better strategies discussed detail. future direction treatments that will aid lowering caused

Язык: Английский

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Hydrogel with ROS Scavenging and Photothermal Sterilizing Activity for Treatment of Diabetic Wound Healing

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(15), С. 17469 - 17481

Опубликована: Июль 29, 2024

With the rising prevalence of diabetes, a growing number patients are at high risk for chronic nonhealing wounds. These wounds severe complication associated with increased rates infection, amputation, and mortality. Currently, there no established clinical approaches effectively treating diabetic wounds, resulting in significant socioeconomic burden on both healthcare systems. Diabetic wound healing is frequently hampered by excessive reactive oxygen species (ROS) biogenesis unrestrained bacterial methicillin-resistant Staphylococcus aureus (MRSA) being particularly aggressive pathogen this setting. Polydopamine nanoparticles (PDA NPs) can readily scavenge ROS facilitate efficient photoconversion. In study, an injectable gelatin methacryloyl (GelMA)/PDA NPs hydrogel, designated GMP, was designed as approach to overcoming these issues through incorporation PDA into GelMA hydrogels. The prepared GMP hydrogel exhibited porous 3D structure amenable injection such that it produce barrier protects site, rapidly providing hemostasis absorbing wound-related exudates. then able exert photothermal sterilizing effects, ultimately alleviating oxidative stress eliminating bacteria from site wounding. This also biocompatible building blocks derived natural materials. vitro vivo, containing improve MRSA-infected healing, underscoring its value tool treatment

Язык: Английский

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Green Tea Carbon Dots‐Based Electrically Active Hydrogel Dressing for Promoting Wound Healing

Advanced Therapeutics, Год журнала: 2024, Номер 7(8)

Опубликована: Июль 1, 2024

Abstract Currently, searching for safer and more effective approaches to promote skin wound healing tissue regeneration is a significant research focus in the field of public health. Eliminating excessive reactive oxygen species (ROS) using electrically active dressings accelerate has gained attention. Herein, green tea‐based carbon dots (GCDs) are synthesized from leaves tea proven possess strong antioxidant, antibacterial, anti‐inflammatory properties. Then, GCDs, polyvinyl alcohol (PVA), poly(3,4‐ethylenedioxythiophene)‐poly(styrenesulfonate) (PEDOT:PSS) successfully constructed into multifunctional conductive PVA‐PEDOT:PSS/GCDs hydrogel (PPPCD) repeated freeze‐thaw method promoting healing. Highly electrical conductivity imparted by introducing PEDOT:PSS, while antioxidant antibacterial properties conferred GCDs. In vitro assays demonstrated excellent biocompatibility hydrogel, as well its ability scavenge ROS cell migration. Furthermore, not only accelerates blood vessel formation epidermal but also alleviating inflammation vivo. Overall, developed dressing demonstrates promising prospects offers new perspective engineering.

Язык: Английский

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