Electrospinning Inorganic Nanomaterials to Fabricate Bionanocomposites for Soft and Hard Tissue Repair

Nanomaterials, Год журнала: 2023, Номер 13(1), С. 204 - 204

Опубликована: Янв. 2, 2023

Tissue engineering (TE) has attracted the widespread attention of research community as a method producing patient-specific tissue constructs for repair and replacement injured tissues. To date, different types scaffold materials have been developed various tissues organs. The choice material should take into consideration whether mechanical properties, biodegradability, biocompatibility, bioresorbability meet physiological properties Owing to their broad range physico-chemical inorganic can induce series biological responses fillers, which render them good alternative (TE). While it is worth further explore mechanistic insight use nanomaterials repair, in this review, we mainly focused on utilization forms strategies fabricating electrospun membranes containing components based electrospinning technology. A particular emphasis placed advantages incorporating along with organic constituents repair. As well widely exploited natural synthetic polymers, offer an enticing platform modulate composite scaffolds, may help broaden application prospect scaffolds TE.

Язык: Английский

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Recent advances in 3D bioprinted cartilage-mimicking constructs for applications in tissue engineering

Materials Today Bio, Год журнала: 2023, Номер 23, С. 100870 - 100870

Опубликована: Ноя. 17, 2023

Human cartilage tissue can be categorized into three types: hyaline cartilage, elastic and fibrocartilage. Each type of possesses unique properties functions, which presents a significant challenge for the regeneration repair damaged tissue. Bionics is discipline in humans study imitate nature. A bionic strategy based on comprehensive knowledge anatomy histology human expected to contribute fundamental core elements repair. Moreover, as novel tissue-engineered technology, 3D bioprinting has distinctive advantage rapid precise construction targeted models. Thus, by selecting suitable materials, cells cytokines, leveraging advanced printing technology concepts, it becomes possible simultaneously realize multiple beneficial achieve improved This article provides an overview key involved combination strategies, with particular focus recent advances mimicking different types

Язык: Английский

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Emerging Smart Micro/Nanofiber‐Based Materials for Next‐Generation Wound Dressings

Advanced Functional Materials, Год журнала: 2023, Номер 34(9)

Опубликована: Ноя. 20, 2023

Abstract Smart wound dressings capable of detecting, monitoring, and regulating complicated dynamic healing processes hold tremendous potential in tissue reconstruction. Micro/nanofiber‐based materials are regarded as one the most promising candidates to develop smart owing their remarkable features including architectural mimicry extracellular matrix, tunability structural assembly, diversity functionality. Herein, latest progress micro/nanoscale fiber‐based terms composition engineering, design, applications management is comprehensively reviewed. This work begins with advances fibers stimuli‐responsive fibers, shape memory conductive fibers. Then, design from conventional 2D fibrous membrane emerging 3D sponge/hydrogel thoroughly discussed. Furthermore, micro/nanofibrous drug delivery, biomechanical stimulation, electrical monitoring highlighted. Finally, article offers perspectives on existing challenges future directions for management.

Язык: Английский

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Hydrophilic/Hydrophobic Janus Nanofibers Containing Compound K for Cartilage Regeneration

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 1683 - 1697

Опубликована: Март 1, 2024

Introduction: Cartilage regeneration is a challenging issue due to poor regenerative properties of tissues. Electrospun nanofibers hold enormous potentials for treatments cartilage defects. However, nanofibrous materials used the treatment defects often require physical and/or chemical modifications promote adhesion, proliferation, and differentiation cells. Thus, it highly desirable improve their surface with functionality. We aim design hydrophilic, adhesive, compound K-loaded Methods: Hydrophilic adhesive K-containing polycaprolactone (CK/PCL NFs) were prepared by coatings gallic acid-conjugated chitosan (CHI-GA). Therapeutic effects CHI-GA/CK/PCL NFs assessed expression level genes involved in matrix degradation, inflammatory response, lipid accumulations chondrocytes. In addition, damage was evaluated safranin O staining immunohistochemistry interleukin-1β (IL-1β) using OA animal models. To explore pathway associated therapeutic NFs, cell phalloidin staining, integrins peroxisome proliferator-activated receptor (PPARs) evaluated. Results: CHI-GA-coated side PCL showed hydrophilic properties, whereas unmodified opposite remained hydrophobic. The levels degradation matrix, inflammation, lipogenesis decreased owing release CK. vivo implantation into reduced induced destabilization medial meniscus (DMM) surgery. Furthermore, accumulation deposition IL-1β through upregulation PPAR. Conclusion: effective inhibiting as well reducing via increasing Keywords: nanofibers, chitosan, K, coating, material,

Язык: Английский

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Biopolymer-Based Nanomedicine for Cancer Therapy: Opportunities and Challenges

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 7415 - 7471

Опубликована: Июль 1, 2024

Abstract: Cancer, as the foremost challenge among human diseases, has plagued medical professionals for many years. While there have been numerous treatment approaches in clinical practice, they often cause additional harm to patients. The emergence of nanotechnology brought new directions cancer treatment, which can deliver anticancer drugs specifically tumor areas. This article first introduces application scenarios nanotherapies and strategies nanomedicine. Then, noteworthy characteristics exhibited by biopolymer materials were described, make biopolymers stand out polymeric nanomedicine delivery. Next, we focus on summarizing state-of-art studies five categories proteins (Albumin, Gelatin, Silk fibroin, Zein, Ferritin), nine varieties polysaccharides (Chitosan, Starch, Hyaluronic acid, Dextran, cellulose, Fucoidan, Carrageenan, Lignin, Pectin) liposomes field drug Finally, also provide a summary advantages limitations these biopolymers, discuss prevailing impediments their application, detail prospective research directions. review not only helps readers understand current development status nano delivery systems based but is helpful properties various find suitable solutions this through comparative reading. Keywords: delivery, nanoformulations, polymer, proteins,

Язык: Английский

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Application and progress of smart hydrogel microspheres for regulating oxidative stress in osteoarthritis

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160620 - 160620

Опубликована: Фев. 1, 2025

Язык: Английский

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Tannic Acid Interfacial Modification of Prochloraz Ethyl Cellulose Nanoparticles for Enhancing the Antimicrobial Effect and Biosafety of Fungicides

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(35), С. 41324 - 41336

Опубликована: Авг. 21, 2023

With the poorly soluble and intrinsically unstable feature, prochloraz (Pro) was confronted with lower bioavailability in crop defense against fungal erosion. Therefore, it a challenging project to explore innovative antifungal compound delivery system for improving bioavailability. The superior adhesive fungicide formulation supposed be an efficient pathway enhance transmembrane permeability biological activity. According abundant phenolic hydroxyl groups, tannic acid (TA) ideal modified biomaterial improve interfacial interactions. fundamental purpose of this research focused on synergistic mechanism TA-interfacial-modified Pro-ethyl cellulose (EC) nanoparticles biosafety. In stability test, TA-modified Pro-EC had capacity reduce Pro initial release burst, extending persistent validity anti-photodegradation property. toxicity index Pro-EC-TA approximately 2.93-fold 4.96-fold that technical Fusarium graminearum (F. graminearum), respectively. Compared nonmodified EC nanoparticles, obtained eminent adherence ability F. graminearum, carboxyl groups TA interaction target cell membranes. contents cellular reactive oxygen species induced by were about 2.31 times 3.00 control check (CK), CK group, membrane potential ergosterol values treated drastically reduced 74.91 56.20%, biosafety assay, maximum half-lethal concentration value indicated acute adult zebrafish 8.34-fold compared technical. These findings demonstrated successful modification highly efficient, environmentally safe, promising alternative sustainable agricultural application, thus making process more simplified, easier fabrication, cost.

Язык: Английский

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New dimensions of electrospun nanofiber material designs for biotechnological uses

Trends in biotechnology, Год журнала: 2023, Номер 42(5), С. 631 - 647

Опубликована: Дек. 28, 2023

Язык: Английский

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Microenvironment-responsive nanosystems for osteoarthritis therapy

Engineered Regeneration, Год журнала: 2023, Номер 5(1), С. 92 - 110

Опубликована: Дек. 14, 2023

Osteoarthritis (OA) represents an enduring and widespread global burden, causing significant morbidity disability, whose pathology is characterized by persistent inflammation, progressive cartilage degeneration, abnormal bone homeostasis, excessive synovial hyperplasia, resulting from its complex microenvironment. Unfortunately, current therapeutic approaches for OA remain suboptimal, prompting increased interest in advanced nanotechnology as a means to enhance effects. In recent years, progress has been made the development of versatile nanoplatforms designed specific microenvironment OA, promising results introducing concept "OA nanomedicine". Compared conventional therapies like non-steroidal anti-inflammatory drugs (NSAIDs), nanomedicine offers precise targeted, controllable personalized ways therapy, contributing better outcomes. However, comprehensive review consolidating nanomedicine" currently absent literature. Therefore, this review, we aim unravel key pathological microenvironmental characteristics while summarizing properties advantages nanosystems possessing microenvironment-reprogramming capabilities therapy. First, make retrospection features Furthermore, provide overview advances nanomedicine. Eventually, discuss present challenges associated with insights into future prospects clinical-translational lens. By doing so, can foster propel successful nanomedicine, addressing unmet needs

Язык: Английский

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Electrospun Smart Hybrid Nanofibers for Multifaceted Applications

Macromolecular Rapid Communications, Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

Abstract Smart electrospun hybrid nanofibers represent a cutting‐edge class of functional nanostructured materials with unique collective properties. This review aims to provide comprehensive overview the applications smart in fields energy, catalysis, and biomedicine. Electrospinning is powerful tool fabricate different types nanofibers’ morphologies precise control over structure compositions. Through incorporation various components, such as nanoparticles, nanomoieties, biomolecules, into (co)polymer matrix, can be tailored exhibiting responsiveness external stimuli temperature, pH, or light among others. Herein recent advancements fabrication strategies for are discussed, focusing on electrospinning tools aimed at tailoring developing nanofibers. These include surface functionalization, doping, templating, which enable fine‐tuning mechanical strength, conductivity, biocompatibility. The explores challenges progress development Issues scalability, reproducibility, biocompatibility, environmental sustainability identified key improvement. Furthermore, biomedicine, environment, energy storage, textiles underscore their potential address emerging technologies.

Язык: Английский

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