ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(30), С. 38852 - 38879
Опубликована: Июль 23, 2024
Biophysical
and
clinical
medical
studies
have
confirmed
that
biological
tissue
lesions
trauma
are
related
to
the
damage
of
an
intrinsic
electret
(i.e.,
endogenous
electric
field),
such
as
wound
healing,
embryonic
development,
occurrence
various
diseases,
immune
regulation,
regeneration,
cancer
metastasis.
As
exogenous
electrical
signals,
conductivity,
piezoelectricity,
ferroelectricity,
pyroelectricity,
bioelectroactives
can
regulate
field,
thus
controlling
function
cells
promoting
repair
regeneration
tissues.
Materials,
once
polarized,
harness
their
inherent
polarized
static
fields
generate
field
through
direct
stimulation
or
indirect
interactions
facilitated
by
physical
friction,
ultrasound,
mechanical
stimulation.
The
interaction
with
microenvironment
allows
for
regulation
compensation
signals
in
damaged
microenvironments,
leading
repair.
technique
shows
great
promise
applications
regeneration.
In
this
paper,
generation
change
electroactive
substances
expounded,
latest
research
progress
its
effects
include
bone
repair,
nerve
drug
penetration
promotion,
etc.
Finally,
opportunities
challenges
materials
were
summarized.
Exploring
development
new
mechanism
regulating
changes
may
provide
insights
innovative
methods
disease
treatment
applications.
Pharmaceutics,
Год журнала:
2023,
Номер
15(5), С. 1338 - 1338
Опубликована: Апрель 26, 2023
Electric
stimulation
has
been
used
in
changing
the
morphology,
status,
membrane
permeability,
and
life
cycle
of
cells
to
treat
certain
diseases
such
as
trauma,
degenerative
disease,
tumor,
infection.
To
minimize
side
effects
invasive
electric
stimulation,
recent
studies
attempt
apply
ultrasound
control
piezoelectric
effect
nano
material.
This
method
not
only
generates
an
field
but
also
utilizes
benefits
non-invasive
mechanical
effects.
In
this
review,
important
elements
system,
piezoelectricity
nanomaterial
ultrasound,
are
first
analyzed.
Then,
we
summarize
categorized
into
five
kinds,
nervous
system
treatment,
musculoskeletal
tissues
cancer
anti-bacteria
therapy,
others,
prove
two
main
mechanics
under
activated
piezoelectricity:
one
is
biological
change
on
a
cellular
level,
other
piezo-chemical
reaction.
However,
there
still
technical
problems
be
solved
regulation
processes
completed
before
widespread
use.
The
core
include
how
accurately
measure
properties,
concisely
electricity
release
through
complex
energy
transfer
processes,
deeper
understanding
related
bioeffects.
If
these
conquered
future,
nanomaterials
by
will
provide
new
pathway
realize
application
disease
treatment.
