International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 12769 - 12791
Опубликована: Ноя. 1, 2024
Sonodynamic
therapy
(SDT)
utilizes
specific
sound
waves
to
activate
sonosensitizers,
generating
localized
biological
effects
eliminate
tumor
cells.
With
advancements
in
nanomedicine,
the
application
of
nano-acoustic
sensitizers
has
significantly
advanced
development
SDT.
BaTiO3
(BTO),
an
inorganic
sensitizer,
possesses
light
refraction
characteristics
and
a
high
dielectric
constant,
can
generate
electric
field
under
ultrasound
(US)
stimulation.
continuous
progress
multidisciplinary
fields
US
research,
scientists
have
developed
various
types
barium
titanate
nanoparticles
(BTNPs)
further
advance
SDT
research
applications
therapy.
In
this
review,
we
present
recently
proposed
representative
BTNPs,
including
their
pathways
action,
such
as
induction
cell
senescence,
ferroptosis,
glutathione
depletion
reshape
microenvironment,
well
surface
modifications.
Research
indicates
that
mechanisms
action
ultrasound-driven
BTNPs
are
multifaceted.
These
mechanisms,
whether
utilized
individually
or
synergistically,
offer
potent
targeted
strategy
for
cancer
treatment.
Furthermore,
discuss
types.
Finally,
summarize
current
challenges
future
prospects
clinical
translation
BTNPs.
Abstract
Sonodynamic
therapy
(SDT)
as
a
promising
non‐invasive
anti‐tumor
means
features
the
preferable
penetration
depth,
which
nevertheless,
usually
can't
work
without
sonosensitizers.
Sonosensitizers
produce
reactive
oxygen
species
(ROS)
in
presence
of
ultrasound
to
directly
kill
tumor
cells,
and
concurrently
activate
immunity
especially
after
integration
with
microenvironment
(TME)‐engineered
nanobiotechnologies
combined
therapy.
Current
sonosensitizers
are
classified
into
organic
inorganic
ones,
current
most
reviews
only
cover
highlighted
their
applications.
However,
there
have
few
specific
that
focus
on
including
design
principles,
regulation,
etc.
In
this
review,
first
according
rationales
rather
than
composition,
action
underlying
chemistry
highlighted.
Afterward,
what
how
TME
is
regulated
based
sonosensitizers‐based
SDT
nanoplatform
an
emphasis
targets‐engineered
elucidated.
Additionally,
applications
non‐cancer
diseases
also
outlined.
Finally,
setbacks
challenges,
proposed
potential
solutions
future
directions
pointed
out.
This
review
provides
comprehensive
detailed
horizon
sonosensitizers,
will
arouse
more
attentions
SDT.
Journal of Magnesium and Alloys,
Год журнала:
2023,
Номер
11(10), С. 3399 - 3426
Опубликована: Окт. 1, 2023
Cancer
is
a
major
threat
to
human
life
worldwide.
Traditional
cancer
treatments,
such
as
chemotherapy
and
surgery,
have
limitations
can
cause
irreversible
damage
normal
tissues
while
killing
the
cells.
Magnesium
(Mg)
alloys
are
widely
reported
novel
potential
biomedical
materials
with
acceptable
mechanical
properties
good
osteogenic
angiogenic
properties.
In
this
review,
we
summarize
Mg
for
antitumor
applications,
including
pure
(Mg-Ag,
Mg-Gd,
Mg-Li-Zn,
Mg-Ca-Sr-Zn,
et
al.)
fabricated
by
casting
extruding,
selective
laser
melting
methods.
exhibit
effect
on
bone
tumor,
breast
cancer,
liver
etal.
What's
more,
after
tumor
tissue
eliminated,
prevent
recurrence,
fill
defects
promote
regeneration.
The
effects
of
mainly
due
their
degradation
products.
Overall,
show
great
in
treatments
dual
function
Abstract
Wireless
energy
transfer
(WET)
based
on
ultrasound‐driven
generators
with
enormous
beneficial
functions,
is
technologically
in
progress
by
the
valuation
of
ultrasonic
metamaterials
(UMMs)
science
and
engineering
domains.
Indeed,
novel
metamaterial
structures
can
develop
efficiency
mechanical
physical
features
ultrasound
receivers
(US‐ETs),
including
piezoelectric
triboelectric
nanogenerators
(US‐PENGs
US‐TENGs)
for
advantageous
applications.
This
review
article
first
summarizes
fundamentals,
classification,
design
UMMs
after
introducing
WET
technology.
In
addition
to
addressing
using
UMMs,
topical
innovative
US‐ETs
conceptually
presented.
Moreover,
advanced
approaches
are
reported
categorized
applications
US‐PENGs
US‐TENGs.
Finally,
some
current
perspectives
encounters
offered.
With
this
objective
mind,
explores
potential
revolution
reliable
integrated
systems
through
transformation
into
active
mediums
generators.
The Innovation Life,
Год журнала:
2024,
Номер
2(2), С. 100074 - 100074
Опубликована: Янв. 1, 2024
<p>Ultrasound,
an
exogenous
physical
stimulus,
has
important
application
prospects
in
the
field
of
regenerative
medicine,
especially
skin
regeneration,
due
to
its
safety,
controllability,
and
deep
penetration
depth.
This
review
examines
potential
ultrasound
therapy
promoting
regeneration
by
exploring
effects
on
cells,
mechanisms
action
responsive
materials.
With
tissue
excellent
biocompatibility,
presents
attractive
option
for
enhancing
wound
healing
regeneration.
By
discussing
current
challenges
future
prospects,
this
offers
insights
guide
development
innovative
ultrasound-based
approaches
clinical
treatment.</p>
Nanoenergy Advances,
Год журнала:
2023,
Номер
3(4), С. 315 - 342
Опубликована: Окт. 16, 2023
Collecting
ambient
energy
to
power
various
wearable
electronics
is
considered
a
prospective
approach
addressing
their
consumption.
Mechanical
and
thermal
energies
are
abundantly
available
in
the
environment
can
be
efficiently
converted
into
electricity
based
on
different
physical
effects.
Hydrogel-based
harvesters
have
turned
out
promising
solution,
owing
unique
properties
including
flexibility
biocompatibility.
In
this
review,
we
provide
concise
overview
of
methods
achievements
hydrogel-based
harvesters,
triboelectric
nanogenerators,
piezoelectric
thermoelectric
generators,
demonstrating
applications
generation,
such
as
LED
lighting
capacitor
charging.
Furthermore,
specifically
focus
self-powered
wearables,
detecting
human
motion/respiration
states,
monitoring
joint
flexion,
promoting
wound
healing,
recording
temperature.
addition,
discuss
progress
sensing
by
hybridizing
multiple
conversion
field
wearables.
This
review
analyzes
for
devices,
with
aim
stimulating
ongoing
advancements
smart
sensors
intelligent
electronics.
Electrical
stimulation
(ES)
of
cellular
systems
can
be
utilized
for
biotechnological
applications
and
electroceuticals
(bioelectric
medicine).
Neural
cell
especially
has
a
long
history
in
neuroscience
research
is
increasingly
applied
clinical
therapies.
Application
ES
via
conventional
electrodes
requires
external
connectors
power
sources,
hindering
scientific
therapeutic
applications.
Here
engineering
novel
3D
scaffold-free
human
neural
stem
constructs
with
integrated
piezoelectric
nanoparticles
enhanced
tissue
induction
function
described.
Tetragonal
barium
titanate
(BaTi03)
are
employed
as
stimulators
prepared
cytocompatible
dispersions,
incorporated
into
self-organizing
spheroids,
activated
wirelessly
by
ultrasound.
Ultrasound
delivery
(low
frequency;
40
kHz)
optimized
survival,
nanoparticle
activation
enabled
throughout
the
spheroids
during
differentiation,
formation,
maturation.
The
resultant
tissues
represent
first
example
direct
loading
particles
ensuing
ultrasound-mediated
enhancement
neuronal
from
cells,
including
augmented
neuritogenesis
synaptogenesis.
It
anticipated
that
platform
described
will
facilitate
advanced
vitro
modeling
(and
potentially
non-neural)
tissues,
development
pathology,
applicable
to
preclinical
testing
prototyping
both
pharmaceuticals.
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Chitosan
(CHT)
is
a
known
piezoelectric
biomacromolecule;
however,
its
usage
limited
due
to
rapid
degradation
in
an
aqueous
system.
Herein,
we
prepared
CHT
film
via
solvent
casting
method
and
cross-linked
alkaline
solution.
Sodium
hydroxide
facilitated
deprotonation,
leading
increased
intramolecular
hydrogen
bonding
mechanical
properties.
The
remained
intact
for
30
days
environments.
A
systematic
study
revealed
gradual
increase
the
output
voltage
from
0.9
1.8
V
under
external
force
(1-16
N).
In
addition,
showed
remarkable
antibacterial
anti-inflammatory
activities
ultrasound
stimulation
inhibition
of
inflammatory
cytokines.
films
also
displayed
enhanced
cellular
proliferation
∼5-fold
faster
migration
NIH3T3
cells
US
stimulation.
Overall,
this
work
presents
robust,
biocompatible,
wearable
device
that
can
transform
biomechanical
energy
into
electrical
pulses
modulation
cell
fate
processes
other
bioactivities.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 29, 2025
Cancer
cells
possess
distinct
bioelectrical
properties,
yet
therapies
leveraging
these
characteristics
remain
underexplored.
Herein,
we
introduce
an
innovative
nanobioelectronic
system
combining
a
piezoelectric
barium
titanate
nanoparticle
core
with
conducting
poly(3,4-ethylenedioxythiophene)
shell
(BTO@PEDOT
NPs),
designed
to
modulate
cancer
cell
bioelectricity
through
noninvasive,
wireless
stimulation.
Our
hypothesis
is
that
acting
as
nanoantennas,
BTO@PEDOT
NPs
convert
mechanical
inputs
provided
by
ultrasound
(US)
into
electrical
signals,
capable
of
interfering
the
bioelectronic
circuitry
two
human
breast
lines,
MCF-7
and
MDA-MB-231.
Upon
US
stimulation,
viability
MDA-MB-231
treated
200
μg
mL-1
reduced
significantly
31%
24%,
respectively,
while
healthy
mammary
fibroblasts
(HMF)
were
unaffected
treatment.
Subsequent
assays
shed
light
on
how
this
approach
could
interact
cell's
mechanisms,
namely,
increasing
intracellular
reactive
oxygen
species
(ROS)
calcium
concentrations.
Furthermore,
was
able
polarize
membranes,
halting
their
cycle
potentially
harnessing
tumorigenic
characteristics.
These
findings
underscore
crucial
role
in
progression
highlight
potential
systems
emerging
promising
strategy
for
intervention.
