Dunyā.,
Год журнала:
2023,
Номер
17(1), С. 11 - 20
Опубликована: Янв. 1, 2023
Xanthene
and
its
derivatives
are
important
in
medical
diagnosis
laser
technology.In
this
work,
spectral
features
of
fluorescein
disodium
were
investigated
different
environments
with
polarity
characteristics.Hence,
the
absorption
fluorescence
spectra
molecule
studied
environments.Our
resultsshow
that
depend
strongly
on
substituents
structure
molecular
interactions.To
investigate
contribution
various
interactions
behavior
used
sample,
linear
solvation
energy
relationship
concept
is
used.Moreover,
dipole
moment
variations
from
ground
to
excited
states
estimated
using
solvent
media.According
results,
value
state
higher
than
state.
Abstract
Bacterial
infection
continues
to
be
an
increasing
global
health
problem
with
the
most
widely
accepted
treatment
paradigms
restricted
antibiotics.
However,
overuse
and
misuse
of
antibiotics
have
triggered
multidrug
resistance
bacteria,
frustrating
therapeutic
outcomes,
leading
higher
mortality
rates.
Even
worse,
tendency
bacteria
form
biofilms
on
living
nonliving
surfaces
further
increases
difficulty
in
confronting
because
extracellular
matrix
can
act
as
a
robust
barrier
prevent
penetration
resist
environmental
damage.
As
result,
inability
eliminate
often
leads
persistent
infection,
implant
failure,
device
Therefore,
it
is
paramount
importance
develop
alternative
antimicrobial
agents
while
avoiding
generation
bacterial
large‐scale
growth
resistance.
In
recent
years,
nano‐antibacterial
materials
played
vital
role
antibacterial
field
their
excellent
physical
chemical
properties.
This
review
focuses
new
physicochemical
strategies
versatile
nanomaterials,
especially
mechanism
types
2D
nanomaterials.
addition,
this
advanced
provides
guidance
development
direction
antibiotic‐free
disinfections
future.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 29, 2024
Abstract
The
challenge
in
treating
diabetic
foot
infections
caused
by
drug‐resistant
bacteria
is
rapidly
eradicating
and
accelerating
wound
healing.
NIR‐II‐induced
photothermal
therapy
(PTT)
offers
notable
advantages
over
conventional
treatments,
such
as
broad‐spectrum
bactericidal
efficacy,
better
penetration
depth
biological
tissues,
higher
skin
tolerance
thresholds,
making
it
particularly
suitable
for
addressing
infections.
Herein,
found
that
NIR‐II
dye
IR26
exhibited
good
effects
but
poor
stability.
By
modifying
with
methoxy
triphenylamine
groups,
a
novel
D–A–D‐type
small
molecule
agent
(IRC)
developed,
high
stability
conversion
efficiency
(44.3%).
IRC
maximum
absorption
wavelength
of
1166
nm
emission
1238
nm.
However,
PTT
alone
cannot
effectively
promote
Therefore,
nanoplatforms
(Cur‐IRC@PCM)
are
developed
coloading
curcumin,
natural
wound–healing
compound,
into
thermosensitive
liposomes
to
treat
MRSA‐infected
wounds.
Under
980
laser
irradiation,
Cur‐IRC@PCM
provided
controlled
the
precise
release
synergizing
eradicate
accelerate
closure.
intelligent
antibacterial
also
exhibits
excellent
biocompatibility,
rendering
promising
therapeutic
tool
biomedical
fields
combating
bacterial
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(17)
Опубликована: Март 23, 2024
The
problem
of
antibiotic
resistance
seriously
affects
the
treatment
bacterial
infections,
so
there
is
an
urgent
need
to
develop
novel
antibiotic-independent
antimicrobial
strategies.
Herein,
a
urease-driven
bowl-like
mesoporous
polydopamine
nanorobot
(MPDA@ICG@Ur@Man)
based
on
single-wavelength
near-infrared
(NIR)
remote
photothermal
acceleration
achieve
antibiotic-free
phototherapy(photothermal
therapy,
PTT,
plus
photodynamic
PDT)
first
reported.
smart
nanorobots
can
perform
active
movement
by
decomposing
urea
produce
carbon
dioxide
and
ammonia.
Particularly,
elevated
local
temperature
during
PTT
increase
urease
activity
enhance
autonomous
thus
contact
between
substance
bacteria.
Compared
with
nanomotor
propelled
only,
diffusion
coefficient
(D
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(27), С. 32967 - 32983
Опубликована: Июнь 29, 2023
Due
to
the
mortality
associated
with
thrombosis
and
its
high
recurrence
rate,
there
is
a
need
investigate
antithrombotic
approaches.
Noninvasive
site-specific
thrombolysis
current
approach
being
used;
however,
usage
characterized
by
following
limitations:
low
targeting
efficiency,
poor
ability
penetrate
clots,
rapid
half-life,
lack
of
vascular
restoration
mechanisms,
risk
thrombus
that
comparable
traditional
pharmacological
agents.
Therefore,
it
vital
develop
an
alternative
technique
can
overcome
aforementioned
limitations.
To
this
end,
cotton-ball-shaped
platelet
(PLT)-mimetic
self-assembly
framework
engineered
phototherapeutic
poly(3,4-ethylenedioxythiophene)
(PEDOT)
platform
has
been
developed.
This
capable
delivering
synthetic
peptide
derived
from
hirudin
P6
(P6)
lesions,
forming
P6@PEDOT@PLT
nanomotors
for
noninvasive
thrombolysis,
effective
anticoagulation,
restoration.
Regulated
P-selectin
mediation,
target
site
subsequently
rupture
under
near-infrared
(NIR)
irradiation,
achieving
desirable
sequential
drug
delivery.
Furthermore,
movement
NIR
irradiation
enables
penetration
deep
into
enhancing
bioavailability.
Biodistribution
analyses
have
shown
administered
exhibit
extended
circulation
time
metabolic
capabilities.
In
addition,
photothermal
therapy/photoelectric
therapy
combination
significantly
augment
effectiveness
(ca.
72%)
thrombolysis.
Consequently,
precisely
delivered
resultant
phototherapeutic-driven
heat-shock
protein,
immunomodulatory,
anti-inflammatory,
inhibitory
plasminogen
activator
inhibitor-1
(PAI-1)
activities
restore
vessels
effectively
prevent
rethrombosis.
The
described
biomimetic
represent
promising
option
improving
efficacy
in
thrombus-related
illnesses.
Journal of Materials Chemistry B,
Год журнала:
2023,
Номер
11(11), С. 2287 - 2306
Опубликована: Янв. 1, 2023
Superbugs,
also
known
as
multidrug-resistant
bacteria,
have
become
a
lethal
and
persistent
threat
due
to
their
unresponsiveness
toward
conventional
antibiotics.
The
main
reason
for
this
is
that
superbugs
can
rapidly
mutate
restrict
any
foreign
drug/molecule
in
vicinity.
Herein,
nanomaterial-mediated
therapies
set
path
shown
burgeoning
efficiency
the
ablation
of
superbugs.
Notably,
treatment
modalities
like
photothermal
therapy
(PTT)
prominence
killing
bacteria
with
ability
generate
local
heat
shock-mediated
hyperthermia
such
species.
However,
has
some
serious
limitations,
high
cost,
complexity,
even
toxicity
extent.
Hence,
it
important
resolve
shortcomings
PTTs
they
provide
substantial
tissue
penetration.
This
why
multimodal
emerged
taken
over
domain
research
past
few
years.
In
work,
we
summarized
critically
reviewed
exceptional
works
recent
times
provided
perspective
enhance
efficiencies.
Profoundly,
discuss
design
rationales
novel
agents
(PTAs)
shed
light
on
mechanisms.
Finally,
challenges
PTT-derived
are
presented,
capable
synergistic
bactericidal
prospects
anticipated.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 15, 2024
Exploring
effective
antibacterial
approaches
for
targeted
treatment
of
pathogenic
bacterial
infections
with
reduced
drug
resistance
is
great
significance.
Combinational
modality
that
leverages
different
therapeutic
components
can
improve
the
overall
effectiveness
and
minimize
adverse
effects,
thus
displaying
considerable
potential
against
infections.
Herein,
red
blood
cell
membrane
fuses
macrophage
to
develop
hybrid
shell,
which
further
camouflages
around
drug-loaded
liposome
fabricate
biomimetic
(AB@LRM)
precise
therapy.
Specifically,
photoactive
agent
black
phosphorus
quantum
dots
(BPQDs)
classical
antibiotics
amikacin
(AM)
are
loaded
in
AB@LRM
accurately
target
inflammatory
sites
through
guidance
long
residence
capability
membrane,
eventually
exerting
efficacious
activities.
Besides,
due
excellent
photothermal
photodynamic
properties,
BPQDs
act
as
an
efficient
when
exposed
near-infrared
laser
irradiation,
dramatically
increasing
sensitivity
bacteria
antibiotics.
Consequently,
synergistic
sterilizing
effect
produced
by
restricts
resistance.
Upon
shows
superior
anti-inflammatory
properties
models
P.
aeruginosa-infected
pneumonia
wounds.
Hence,
this
light-activatable
nanoplatform
good
biocompatibility
presents
advance
clinical
development
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(3)
Опубликована: Май 1, 2024
Abstract
Photothermal
therapy
(PTT)
represents
a
groundbreaking
approach
to
targeted
disease
treatment
by
harnessing
the
conversion
of
light
into
heat.
The
efficacy
PTT
heavily
relies
on
capabilities
photothermal
agents
(PTAs).
Among
PTAs,
those
based
organic
dyes
exhibit
notable
characteristics
such
as
adjustable
absorption
wavelengths,
high
extinction
coefficients,
and
compatibility
in
biological
systems.
However,
challenge
associated
with
dye‐based
PTAs
lies
their
efficiency
converting
heat
while
maintaining
stability.
Manipulating
dye
aggregation
is
key
aspect
modulating
non‐radiative
decay
pathways,
aiming
augment
generation.
This
review
delves
various
strategies
aimed
at
improving
performance
through
constructing
aggregation.
These
including
protecting
from
photodegradation,
inhibiting
non‐photothermal
space
within
molecular
aggregates,
introducing
intermolecular
photophysical
processes.
Overall,
this
highlights
precision‐driven
assembly
promising
frontier
enhancing
PTT‐related
applications.
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Nanomedicine
for
Oncologic
Disease
Diagnostic
Tools
In
Vivo
Nanodiagnostics
Imaging
