International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 126697 - 126697
Опубликована: Сен. 4, 2023
Язык: Английский
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(13)
Опубликована: Фев. 7, 2024
Abstract Diabetic wound healing remains a significant clinical challenge due to the complex microenvironment and attenuated endogenous electric field. Herein, novel all‐in‐one self‐powered microneedle device (termed TZ@mMN‐TENG) is developed by combining multifunctional carried tannin@ZnO microparticles (TZ@mMN) with triboelectric nanogenerator (TENG). In addition delivery of tannin Zn 2+ , TZ@mMN also effectively conducts electrical stimulation (ES) infected diabetic wounds. As device, TENG can convert biomechanical motion into exogenous ES accelerate healing. vitro experiment demonstrated that shows excellent conductive, high antioxidant ability, effective antibacterial properties against both Staphylococcus aureus Escherichia coli (>99% rates). Besides, TZ@mMN‐TENG promote cell proliferation migration. rat full‐thickness skin model eliminate bacteria, epidermal growth (regenerative epidermis: ≈303.3 ± 19.1 µm), enhance collagen deposition, inhibit inflammation (lower TNF‐α IL‐6 expression), angiogenesis (higher CD31 VEGF expression) repair. Overall, provides promising strategy for application in
Язык: Английский
Процитировано
26
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(20)
Опубликована: Май 25, 2024
Acute wounds are converted to chronic due advanced age and diabetic complications. Nanozymes catalyze ROS production kill bacteria without causing drug resistance, while microneedles (MNs) can break through the skin barrier deliver drugs effectively. be intergrateded into MNs delivery systems improve painless delivery. It also reduce effective dose of sterilization increasing efficiency effectively killing wounded preventing resistance. This paper describes various types metal nanozymes from previous studies compares their mutual enhancement with nanozymes. The pooled results show that MNs, material innovation, able both penetrate scab exert additional anti-inflammatory bactericidal effects. catalytic effect some accelerate lysis or create a cascade reaction against inflammation infection. However, issue increased toxicity associated penetration clinical translation remains challenge. study reviews latest published corresponding challenges use combined for treatment wounds, providing further information future research.
Язык: Английский
Процитировано
20
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(12), С. 5161 - 5180
Опубликована: Авг. 23, 2024
Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.
Язык: Английский
Процитировано
20
AAPS PharmSciTech, Год журнала: 2025, Номер 26(1)
Опубликована: Янв. 8, 2025
Язык: Английский
Процитировано
8
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 298, С. 140082 - 140082
Опубликована: Янв. 18, 2025
Язык: Английский
Процитировано
4
Chemical Engineering Journal, Год журнала: 2025, Номер 505, С. 159255 - 159255
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
2
Advanced Materials, Год журнала: 2023, Номер 35(49)
Опубликована: Июнь 3, 2023
Bioadhesives with antimicrobial properties enable easier and safer treatment of wounds as compared to the traditional methods such suturing stapling. Composed natural or synthetic polymers, these bioadhesives seal facilitate healing while preventing infections through activity locally released drugs, nanocomponents, inherently polers. Although many different materials strategies are employed develop bioadhesives, design biomaterials necessitates a prudent approach achieving all required including optimal adhesive cohesive properties, biocompatibility, can be challenging. Designing tunable physical, chemical, biological will shed light on path for future advancement properties. In this review, requirements commonly used developing discussed. particular, their synthesis experimental clinical applications variety organs reviewed. Advances in pave way better management increase positive outcomes.
Язык: Английский
Процитировано
42
Advanced Materials Technologies, Год журнала: 2024, Номер 9(15)
Опубликована: Май 7, 2024
Abstract Controllable and long‐term release remains a great challenge in current drug delivery systems. Benefiting from their efficient loading painless administration, microneedles (MNs) have emerged as promising platform for transdermal delivery, while they often fail to achieve tissue adhesion controllable extended release. Here, 3D printing of an innovative MN patch is presented with succulent‐inspired responsive microstructures light‐controllable capability. The exhibits reversible shrink‐swell volume change behavior response surrounding humidity, which enables sufficient mechanical strength skin penetration under the shrinkage conditions when swollen tissues. Moreover, introduces system, achieved through integration thiolated heparin (Hep‐SH) sustained growth factor graphene oxide (GO) nanosheets controlled via near infrared (NIR) laser irradiation. patches good biocompatibility can promote proliferation, migration, proangiogenesis endothelial cells further demonstrated. Thus, it believed that such flexible be candidates well other related engineering applications.
Язык: Английский
Процитировано
10
International Journal of Pharmaceutics X, Год журнала: 2025, Номер 9, С. 100317 - 100317
Опубликована: Фев. 10, 2025
The conventional oral administration of pioglitazone for Type II diabetes management is frequently compromised by hepatic first-pass metabolism and associated systemic adverse effects, necessitating the development enhanced transdermal delivery approaches. This study developed a drug system combining conductive hydrogel microneedles iontophoresis to improve hydrochloride (PIO) its therapeutic efficacy in treatment type diabetes. microneedles, fabricated using poly(methyl vinyl ether-alt-maleic anhydride) as main matrix material, exhibited excellent conductivity, mechanical strength, high loading capacity. In vitro permeation experiments demonstrated that, when combined with at current intensity 0.5 mA, cumulative PIO reached 238.1 ± 27.14 μg/cm2 within 48 h, significantly higher than that microneedle group alone. diabetic rat model, microneedle-iontophoresis displayed better hypoglycemic effect group, blood glucose reduction 6.3 mmol/L on day 8, 5.1 positive control group. Pharmacokinetic analysis indicated Tmax, T1/2, mean residence time were longer those administration, indicating sustained-release characteristics. Skin irritation tests revealed caused only mild, transient skin irritation, complete recovery 24 h. conclusion, can effectively enhance delivery, bioavailability, while also exhibiting good safety potential clinical application value.
Язык: Английский
Процитировано
1
Burns & Trauma, Год журнала: 2025, Номер 13
Опубликована: Янв. 1, 2025
Abstract Diabetic wounds present a significant challenge in clinical treatment and are characterized by chronic inflammation, oxidative stress, impaired angiogenesis, peripheral neuropathy, heightened risk of infection during the healing process. By creating small channels surface skin, microneedle technology offers minimally invasive efficient approach for drug delivery treatment. This article begins outlining biological foundation normal skin wound unique pathophysiological mechanisms diabetic wounds. It then delves into various types, materials, preparation processes microneedles. The focus is on application multifunctional microneedles treatment, highlighting their antibacterial, anti-inflammatory, immunomodulatory, antioxidant, angiogenic neural repair properties. These demonstrate synergistic therapeutic effects directly influencing microenvironment, ultimately accelerating advancement not only holds promise enhancing outcomes but also new strategies addressing other
Язык: Английский
Процитировано
1