Enhanced osteogenesis and inflammation suppression in 3D printed n-HA/PA66 composite scaffolds with PTH(1-34)-loaded nPDA coatings

Composites Part B Engineering, Год журнала: 2024, Номер 282, С. 111566 - 111566

Опубликована: Май 17, 2024

Язык: Английский

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Photo-Cross-Linkable Hydrogel with Lubricating, Antimicrobial, and Antioxidant Properties for Bacteria-Infected Wound Healing

Chemistry of Materials, Год журнала: 2024, Номер 36(12), С. 6114 - 6129

Опубликована: Июнь 3, 2024

Wound healing is a prolonged physiological process involving series of complicated biological responses influenced by various factors, such as bacterial infection and oxidative damage. Existing treatments, while effective, have certain limitations in terms biocompatibility, responsiveness to the wound environment, efficacy promoting tissue regeneration. To address these shortcomings, bioinspired hydration lubrication mechanism articular cartilage, we successfully designed developed an injectable situ photo-cross-linkable hydrogel, which was synthesized via modifying aminated hyaluronic acid with polymer obtained free radical polymerization o-nitrobenzyl alcohol derivative (NB) 2-methoxyethyl phosphocholine (MPC). The hydrophilic layer formed around zwitterionic charges MPC endowed hydrogel enhanced antimicrobial effects, whereas hydroxymethyl group NB enabled ultraviolet light-induced cross-linking property. doped polydopamine nanoparticles, facilitated multifaceted photothermally responsive antibacterial, anti-inflammation, angiogenesis. Specifically, upon injection precursor solution into site exposure light, cross-linked adhered closely skin tissues, achieving hemostasis exudate absorption. Additionally, showed excellent reactive oxygen species scavenging property, reducing cellular stress meanwhile bactericidal effect near-infrared light irradiation. Furthermore, its networked porous structure, conducive cell adhesion proliferation, remarkably enhancing activity wound-healing performances were investigated both vitro vivo experiments, showcasing potential for treatment applications, offering promising improvement over current methods providing photothermal responsive, biocompatible, effective process.

Язык: Английский

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Fucoidan modulates gut microbiota and immunity in Peyer's patches against inflammatory bowel disease

Carbohydrate Polymers, Год журнала: 2024, Номер 342, С. 122421 - 122421

Опубликована: Июнь 19, 2024

Язык: Английский

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2D Is Better: Engineering Polydopamine into Cationic Nanosheets to Enhance Anti‐Inflammatory Capability

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(18)

Опубликована: Март 11, 2024

Polydopamine nanomaterials have emerged as one of the most popular organic materials for management oxidative stress-mediated inflammatory diseases. However, their current anti-inflammatory ability is still unsatisfactory because limited phenolic hydroxyl groups, and oxidation reaction-medicated reactive oxygen nitrogen species (RONS) scavenging. Herein, via fusing dimension engineering surface charge engineering, 2D cationic polydopamine nanosheets (PDA NSs) capable scavenging multiple danger signals to enhance capability are reported. Compared with conventional spherical nanoparticles, PDA NSs exhibit three- fourfold enhancement in RONS capability, which should be attributed high specific area abundant phenol groups ultrathin structure. To further ability, polylysine molecules absorbed on endow cell-free DNA (cfDNA), another typical factor exacerbate pathogenesis inflammation. Molecular mechanisms reveal that can concurrently activate Keap1-Nrf2 block TLR9 signaling pathway, achieving synergistical inflammation inhibition. As a proof concept, cfDNA dual-scavenging effectively alleviate bowel disease both delayed prophylactic models, much better than clinical drug 5-aminosalicylic acid.

Язык: Английский

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Nanoparticle-Based Drug Delivery Systems for Inflammatory Bowel Disease Treatment

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 2921 - 2949

Опубликована: Июль 1, 2024

Abstract: Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory condition characterized by recurring inflammation of the intestinal mucosa. However, existing IBD treatments are ineffective and have serious side effects. The etiology multifactorial encompasses immune, genetic, environmental, dietary, microbial factors. nanoparticles (NPs) developed based on specific targeting methodologies exhibit great potential as nanotechnology advances. Nanoparticles defined particles between 1 100 nm in size. Depending their size surface functionality, NPs different properties. A variety nanoparticle types been employed drug carriers for treatment (IBD), with encouraging outcomes observed experimental models. They increase bioavailability drugs enable targeted delivery, promoting localized thus enhancing efficacy. Nevertheless, numerous challenges persist translation from nanomedicine to clinical application, including enhanced formulations preparation techniques, safety profiles, so forth. In future, it will be necessary scientists clinicians collaborate order study mechanisms, develop new delivery strategies, screen nanomedicines. Keywords: nanoparticles, diseases, passive targeting, active system

Язык: Английский

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Effectively alleviate rheumatoid arthritis via maintaining redox balance, inducing macrophage repolarization and restoring homeostasis of fibroblast-like synoviocytes by metformin-derived carbon dots

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 29, 2025

Overproduction of reactive oxygen species (ROS), elevated synovial inflammation, hyperplasia and fibrosis are the main characteristic microenvironment in rheumatoid arthritis (RA). Macrophages fibroblast-like synoviocytes (FLSs) play crucial roles progression RA. Hence, synergistic combination ROS scavenging, macrophage polarization from pro-inflammatory M1 phenotype towards M2 anti-inflammatory phenotype, restoring homeostasis FLSs will provide a promising therapeutic strategy for In this study, we successfully synthesized metformin-derived carbon dots (MCDs), investigated antirheumatic effect vivo vitro. Designed MCDs could target inflamed cells accumulate at inflammatory joints collagen-induced (CIA) rats. investigation suggested that reduced inflammation hyperplasia, ultimately prevented cartilage destruction, bone erosion, CIA addition, eliminated cellular macrophages RA through enzyme-like catalytic activity as well inhibiting NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome signaling pathway, effectively polarizing them into to realize effect. Furthermore, inhibit proliferation, migration, FLSs. Mechanistically, restored while reducing level by blocking IL-6/gp130 pathway. Combined with preferable biocompatibility, offer prospective treatment approach

Язык: Английский

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Gut Microbiota Serves as a Crucial Independent Biomarker in Inflammatory Bowel Disease (IBD)

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2503 - 2503

Опубликована: Март 11, 2025

Inflammatory bowel disease (IBD), encompassing Crohn’s (CD), ulcerative colitis (UC), and IBD unclassified (IBD-U), is a complex intestinal disorder influenced by genetic, environmental, microbial factors. Recent evidence highlights the gut microbiota as pivotal biomarker modulator in pathogenesis. Dysbiosis, characterized reduced diversity altered composition, hallmark of IBD. A consistent decrease anti-inflammatory bacteria, such Faecalibacterium prausnitzii, an increase pro-inflammatory species, including Escherichia coli, have been observed. Metabolomic studies reveal decreased short-chain fatty acids (SCFAs) secondary bile acids, critical for homeostasis, alongside elevated metabolites. The interacts with host immune pathways, influencing morphogens, glycosylation, podoplanin (PDPN) expression. disruption glycosylation impairs mucosal barriers, while aberrant PDPN activity exacerbates inflammation. Additionally, alterations contribute to oxidative stress, further destabilizing barriers. These molecular cellular disruptions underscore role microbiome pathophysiology. Emerging therapeutic strategies, probiotics, prebiotics, dietary interventions, aim restore balance mitigate Advanced on microbiota-targeted therapies their potential reduce severity improve patient outcomes. Nevertheless, research needed elucidate bidirectional interactions between responses translate these insights into clinical applications. This review consolidates current findings microbiota’s IBD, emphasizing its diagnostic implications, advocates continued exploration microbiome-based interventions combat this debilitating disease.

Язык: Английский

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Macrophage‐Biomimetic Nanoplatform‐Based Therapy for Inflammation‐Associated Diseases

Small Methods, Год журнала: 2023, Номер 8(7)

Опубликована: Ноя. 30, 2023

Abstract Inflammation‐associated diseases are very common clinically with a high incidence; however, there is still lack of effective treatments. Cell‐biomimetic nanoplatforms have led to many breakthroughs in the field biomedicine, significantly improving efficiency drug delivery and its therapeutic implications especially for inflammation‐associated diseases. Macrophages an important component immune cells play critical role occurrence progression while simultaneously maintaining homeostasis modulating responses. Therefore, macrophage‐biomimetic not only inherit functions macrophages including inflammation tropism effect targeted drugs neutralization pro‐inflammatory cytokines toxins via membrane surface receptors or proteins, but also maintain inner nanoparticles. Macrophage‐biomimetic shown remarkable efficacy excellent application potential In this review, diseases, physiological macrophages, classification construction first introduced. Next, latest applications different treatment summarized. Finally, challenges opportunities future biomedical discussed. It hoped that review will provide new ideas further development nanoplatforms.

Язык: Английский

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Cell membrane nanomaterials composed of phospholipids and glycoproteins for drug delivery in inflammatory bowel disease: A review

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 249, С. 126000 - 126000

Опубликована: Июль 31, 2023

Язык: Английский

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Multifunctional Polymer Vesicles for Synergistic Antibiotic–Antioxidant Treatment of Bacterial Keratitis

Biomacromolecules, Год журнала: 2023, Номер 24(11), С. 5230 - 5244

Опубликована: Сен. 21, 2023

As an acute ophthalmic infection, bacterial keratitis (BK) can lead to severe visual morbidity, such as corneal perforation, intraocular and permanent opacity, if rapid effective treatments are not available. In addition eradicating pathogenic bacteria, protecting tissue from oxidative damage promoting wound healing by relieving inflammation equally critical for the efficient treatment of BK. Besides, it is very necessary improve bioavailability drugs enhancing ocular surface adhesion permeability. this investigation, therefore, a synergistic antibiotic-antioxidant BK was achieved based on multifunctional block copolymer vesicles, within which ciprofloxacin (CIP) simultaneously encapsulated during self-assembly. Due phenylboronic acid residues in corona layer, these vesicles exhibited enhanced muco-adhesion, deep epithelial penetration, bacteria-targeting, facilitated drug delivery infection sites. Additionally, abundant thioether moieties hydrophobic membrane enabled both have ROS-scavenging capacity accelerated CIP release at inflammatory tissue. vivo experiments mice model demonstrated that polymer BK, owing bacteria targeting, ROS-triggered release, combined antioxidant-antibiotic therapy. This strategy holds great potential other diseases associated with infections.

Язык: Английский

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