A Modified Polydopamine Nanoparticle Loaded with Melatonin for Synergistic ROS Scavenging and Anti‐Inflammatory Effects in the Treatment of Dry Eye Disease DOI Open Access

Xue Yang,

Bowen Wang, Hao Zeng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Dry eye disease (DED) is a multifaceted ocular surface disorder that significantly impacts patients’ daily lives and imposes substantial economic burden on society. Oxidative stress, induced by the overproduction of reactive oxygen species (ROS), critical factor perpetuating inflammatory cycle in DED. Effectively scavenging ROS essential to impede progression In this study, boronophenylalanine‐ containing polydopamine (PDA‐PBA) nanoparticles are developed loaded with melatonin (MT), which blended poly(vinyl alcohol) (PVA) create drops PVA/ PDA‐PBA@MT (PPP@MT). vitro vivo studies demonstrate PPP@MT exhibits dual functionalities reducing production downregulating pathways, thereby preserving mitochondrial integrity further inhibiting programmed cell death. Following treatment, tear secretion, corneal structure, number goblet cells markedly restored mouse model dry eye, indicating therapeutic efficacy agent. Collectively, PPP@MT, characterized minimal side effects favorable bioavailability, offers promising insights for management DED other ROS‐mediated disorders.

Language: Английский

2D Is Better: Engineering Polydopamine into Cationic Nanosheets to Enhance Anti‐Inflammatory Capability DOI
Lulu Liu, Chenxin Lu, Zhenchao Tao

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(18)

Published: March 11, 2024

Polydopamine nanomaterials have emerged as one of the most popular organic materials for management oxidative stress-mediated inflammatory diseases. However, their current anti-inflammatory ability is still unsatisfactory because limited phenolic hydroxyl groups, and oxidation reaction-medicated reactive oxygen nitrogen species (RONS) scavenging. Herein, via fusing dimension engineering surface charge engineering, 2D cationic polydopamine nanosheets (PDA NSs) capable scavenging multiple danger signals to enhance capability are reported. Compared with conventional spherical nanoparticles, PDA NSs exhibit three- fourfold enhancement in RONS capability, which should be attributed high specific area abundant phenol groups ultrathin structure. To further ability, polylysine molecules absorbed on endow cell-free DNA (cfDNA), another typical factor exacerbate pathogenesis inflammation. Molecular mechanisms reveal that can concurrently activate Keap1-Nrf2 block TLR9 signaling pathway, achieving synergistical inflammation inhibition. As a proof concept, cfDNA dual-scavenging effectively alleviate bowel disease both delayed prophylactic models, much better than clinical drug 5-aminosalicylic acid.

Language: Английский

Citations

7
Fucoidan modulates gut microbiota and immunity in Peyer's patches against inflammatory bowel disease DOI
Jiakang Li, Suresh Veeraperumal, Jude Juventus Aweya

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 342, P. 122421 - 122421

Published: June 19, 2024

Language: Английский

Citations

7
Restore Intestinal Barrier Integrity: An Approach for Inflammatory Bowel Disease Therapy DOI Creative Commons
Kong Chen,

Meifeng Yang,

Ningning Yue

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 5389 - 5413

Published: Aug. 1, 2024

The intestinal barrier maintained by various types of columnar epithelial cells, plays a crucial role in regulating the interactions between contents (such as microbiota), immune system, and other components. Dysfunction mucosa is significant pathophysiological mechanism clinical manifestation inflammatory bowel disease (IBD). However, current therapies for IBD primarily focus on suppressing inflammation, no disease-modifying treatments specifically target barrier. Given side effects associated with chronic immunotherapy, effective alternative that promote mucosal healing are highly attractive. In this review, we examined function mechanisms behind its disruption IBD. We illustrated complex process proposed therapeutic approaches to strategies These included application stem cell transplantation organ-like tissue engineering generate new tissue. Finally, discussed potential restore treatment

Language: Английский

Citations

7
Gut microbiota dysbiosis and intestinal barrier impairment in diarrhea caused by cold drink and high-fat diet DOI

Yajuan Tian,

Meng Fu,

Jie Su

et al.

Toxicology, Journal Year: 2024, Volume and Issue: 502, P. 153728 - 153728

Published: Jan. 10, 2024

Language: Английский

Citations

6
Enhanced osteogenesis and inflammation suppression in 3D printed n-HA/PA66 composite scaffolds with PTH(1-34)-loaded nPDA coatings DOI

Zhimou Zeng,

Linnan Wang, Bo Qu

et al.

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 282, P. 111566 - 111566

Published: May 17, 2024

Language: Английский

Citations

6
Nanoparticle-Based Drug Delivery Systems for Inflammatory Bowel Disease Treatment DOI Creative Commons
Jian Gao, Jiannan Li,

Zengyou Luo

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2921 - 2949

Published: July 1, 2024

Abstract: Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory condition characterized by recurring inflammation of the intestinal mucosa. However, existing IBD treatments are ineffective and have serious side effects. The etiology multifactorial encompasses immune, genetic, environmental, dietary, microbial factors. nanoparticles (NPs) developed based on specific targeting methodologies exhibit great potential as nanotechnology advances. Nanoparticles defined particles between 1 100 nm in size. Depending their size surface functionality, NPs different properties. A variety nanoparticle types been employed drug carriers for treatment (IBD), with encouraging outcomes observed experimental models. They increase bioavailability drugs enable targeted delivery, promoting localized thus enhancing efficacy. Nevertheless, numerous challenges persist translation from nanomedicine to clinical application, including enhanced formulations preparation techniques, safety profiles, so forth. In future, it will be necessary scientists clinicians collaborate order study mechanisms, develop new delivery strategies, screen nanomedicines. Keywords: nanoparticles, diseases, passive targeting, active system

Language: Английский

Citations

6
Macrophage‐Biomimetic Nanoplatform‐Based Therapy for Inflammation‐Associated Diseases DOI
Ying Qu, Bingyang Chu, Jianan Li

et al.

Small Methods, Journal Year: 2023, Volume and Issue: 8(7)

Published: Nov. 30, 2023

Abstract Inflammation‐associated diseases are very common clinically with a high incidence; however, there is still lack of effective treatments. Cell‐biomimetic nanoplatforms have led to many breakthroughs in the field biomedicine, significantly improving efficiency drug delivery and its therapeutic implications especially for inflammation‐associated diseases. Macrophages an important component immune cells play critical role occurrence progression while simultaneously maintaining homeostasis modulating responses. Therefore, macrophage‐biomimetic not only inherit functions macrophages including inflammation tropism effect targeted drugs neutralization pro‐inflammatory cytokines toxins via membrane surface receptors or proteins, but also maintain inner nanoparticles. Macrophage‐biomimetic shown remarkable efficacy excellent application potential In this review, diseases, physiological macrophages, classification construction first introduced. Next, latest applications different treatment summarized. Finally, challenges opportunities future biomedical discussed. It hoped that review will provide new ideas further development nanoplatforms.

Language: Английский

Citations

16
Photo-Cross-Linkable Hydrogel with Lubricating, Antimicrobial, and Antioxidant Properties for Bacteria-Infected Wound Healing DOI

Weicheng Guo,

Qiang Wang, Haimang Wang

et al.

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(12), P. 6114 - 6129

Published: June 3, 2024

Wound healing is a prolonged physiological process involving series of complicated biological responses influenced by various factors, such as bacterial infection and oxidative damage. Existing treatments, while effective, have certain limitations in terms biocompatibility, responsiveness to the wound environment, efficacy promoting tissue regeneration. To address these shortcomings, bioinspired hydration lubrication mechanism articular cartilage, we successfully designed developed an injectable situ photo-cross-linkable hydrogel, which was synthesized via modifying aminated hyaluronic acid with polymer obtained free radical polymerization o-nitrobenzyl alcohol derivative (NB) 2-methoxyethyl phosphocholine (MPC). The hydrophilic layer formed around zwitterionic charges MPC endowed hydrogel enhanced antimicrobial effects, whereas hydroxymethyl group NB enabled ultraviolet light-induced cross-linking property. doped polydopamine nanoparticles, facilitated multifaceted photothermally responsive antibacterial, anti-inflammation, angiogenesis. Specifically, upon injection precursor solution into site exposure light, cross-linked adhered closely skin tissues, achieving hemostasis exudate absorption. Additionally, showed excellent reactive oxygen species scavenging property, reducing cellular stress meanwhile bactericidal effect near-infrared light irradiation. Furthermore, its networked porous structure, conducive cell adhesion proliferation, remarkably enhancing activity wound-healing performances were investigated both vitro vivo experiments, showcasing potential for treatment applications, offering promising improvement over current methods providing photothermal responsive, biocompatible, effective process.

Language: Английский

Citations

5
Cell membrane nanomaterials composed of phospholipids and glycoproteins for drug delivery in inflammatory bowel disease: A review DOI
Pengyu Lei,

Haiyang Yu,

Jiahui Ma

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 249, P. 126000 - 126000

Published: July 31, 2023

Language: Английский

Citations

13
Multifunctional Polymer Vesicles for Synergistic Antibiotic–Antioxidant Treatment of Bacterial Keratitis DOI
Qiumeng Chen,

Xiaopeng Han,

Lu Liu

et al.

Biomacromolecules, Journal Year: 2023, Volume and Issue: 24(11), P. 5230 - 5244

Published: Sept. 21, 2023

As an acute ophthalmic infection, bacterial keratitis (BK) can lead to severe visual morbidity, such as corneal perforation, intraocular and permanent opacity, if rapid effective treatments are not available. In addition eradicating pathogenic bacteria, protecting tissue from oxidative damage promoting wound healing by relieving inflammation equally critical for the efficient treatment of BK. Besides, it is very necessary improve bioavailability drugs enhancing ocular surface adhesion permeability. this investigation, therefore, a synergistic antibiotic-antioxidant BK was achieved based on multifunctional block copolymer vesicles, within which ciprofloxacin (CIP) simultaneously encapsulated during self-assembly. Due phenylboronic acid residues in corona layer, these vesicles exhibited enhanced muco-adhesion, deep epithelial penetration, bacteria-targeting, facilitated drug delivery infection sites. Additionally, abundant thioether moieties hydrophobic membrane enabled both have ROS-scavenging capacity accelerated CIP release at inflammatory tissue. vivo experiments mice model demonstrated that polymer BK, owing bacteria targeting, ROS-triggered release, combined antioxidant-antibiotic therapy. This strategy holds great potential other diseases associated with infections.

Language: Английский

Citations

12