Molecules,
Год журнала:
2024,
Номер
29(23), С. 5728 - 5728
Опубликована: Дек. 4, 2024
The
conductive
hydrogels
(CHs)
are
promising
for
developing
flexible
energy
storage
devices,
sensors,
and
electronic
skin
due
to
the
unique
features
of
excellent
flexibility
high
conductivity.
However,
poor
biocompatibility
antibacterial
properties
seriously
limit
their
application
in
biomedical
field.
Collagen,
one
main
components
extracellular
Matrix
(ECM),
is
ideal
matrix
constructing
good
with
human
tissue.
Here,
dopamine-polypyrrole-collagen
(DA-PPY-COL)
hydrogel
was
constructed
by
dopamine-mediated
pyrrole
situ
polymerization
a
collagen
matrix.
As
strain
sensor,
it
can
be
affixed
different
parts
body
monitor
large-scale
motion
movements
fine
micro-expressions
real
time.
performance
attributed
its
self-adhesion,
flexibility,
electrical
Biological
experiments
have
shown
that
has
antimicrobial
properties,
biocompatibility,
degradability,
allowing
safely
motor
behavior.
This
work
not
only
offers
material
preparation
strategy
biomimetic
wearable
sensors
but
also
demonstrates
great
potential
prospect
implantable
degradable
medical
device
applications.
Abstract
The
emergence
of
multidrug‐resistant
bacteria
poses
a
significant
challenge
in
the
treatment
osteomyelitis,
rendering
traditional
antibiotic
strategies
inadequate
terms
achieving
complete
cure.
In
recent
years,
triggerable
biomaterial‐based,
antibiotic‐free
osteomyelitis
have
rapidly
evolved,
demonstrating
excellent
bactericidal
effects.
Triggerable
biomaterials‐based
theranostics
encompass
physical
signal
response
and
host
immune
modulation
approaches.
These
can
be
effective
against
drug‐resistant
bacteria,
circumventing
gradual
acquisition
resistance
that
often
accompanies
treatment.
Additionally,
inherent
properties
biomaterials
facilitate
precise
imaging
osteomyelitis.
There
is
no
doubt
biomaterial‐mediated,
therapies
are
emerging
as
trend,
which
critically
important
combating
bacteria‐induced
this
review,
we
summarize
latest
advances
from
both
pathogen‐directed
host‐directed
perspectives.
design
regimens
specific
action
mechanisms
biomaterial‐based
nanoplatforms
also
clarified.
Finally,
outline
challenges
faced
by
various
provide
an
outlook
on
prospects
for
synergistic
interactions.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(15), С. 18327 - 18343
Опубликована: Апрель 8, 2024
58S
bioactive
glass
(BG)
has
effective
biocompatibility
and
bioresorbable
properties
for
bone
tissue
engineering;
however,
it
limitations
regarding
antibacterial,
antioxidant,
mechanical
properties.
Therefore,
we
have
developed
BGAC
biocomposites
by
reinforcing
BG
with
silver
ceria
nanoparticles,
which
showed
bactericidal
forming
inhibited
zones
of
2.13
mm
(against
Escherichia
coli)
1.96
Staphylococcus
aureus;
evidenced
disc
diffusion
assay)
an
increment
in
the
antioxidant
39.9%.
Moreover,
elastic
modulus,
hardness,
fracture
toughness
were
observed
to
be
increased
∼84.7%
(∼51.9
GPa),
∼54.5%
(∼3.4
∼160%
(∼1.3
MPam1/2),
whereas
specific
wear
rate
was
decreased
∼55.2%
(∼1.9
×
10-11
m3/Nm).
X-ray
diffraction,
high-resolution
transmission
electron
microscopy,
field
emission
scanning
microscopy
confirmed
fabrication
uniform
distribution
nanomaterials
matrix.
The
addition
nanoparticles
matrix
(in
BGA)
composite
strengthening
damaging
cytoplasmic
membrane
bacterial
cells.
nanoceria
(BGC)
44.5%
(as
2,2-diphenyl-1-picrylhydrazyl
assay).
resazurin
reduction
assay
MTT
cytocompatibility
against
mouse
embryonic
fibroblast
cells
(NIH3T3)
marrow
stromal
Overall,
resulted
comparable
those
cancellous
bone,
its
antibacterial
make
a
good
candidate
healing.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(40)
Опубликована: Июль 1, 2024
Abstract
The
hypoxic
environment
of
deep
tissue
and
the
weak
energy
microwave
(MW)
are
still
major
limitations
MW
catalytic
therapy.
In
this
work,
an
MW‐responsive
nano‐platform
consisting
Mn‐doped
porphyrin
metal–organic
framework
loaded
with
calcium
peroxide
(Mn
0.1
PCC)
is
designed
to
regulate
microenvironment
injection
site
enhance
generation
reactive
oxygen
species.
excellent
absorbing
properties
Mn
PCC
improve
Fenton
reaction
between
hydrogen
formed
by
hydrolysis
released
2+
generating
more
hydroxyl
radicals
under
MW.
This
process
does
not
consume
substrate
even
produces
environment.
Therefore,
at
a
low
safe
concentration
(125
µg
mL
−1
),
antibacterial
rate
against
4
×
10
8
CFU
methicillin‐resistant
Staphylococcus
aureus
(MRSA)
after
irradiation
for
15
min
99.71%
±
0.18%.
PCC,
upon
exposure
MW,
prevents
recurrence
bacterial
infections
overcomes
drug
resistance
inhibiting
quorum
sensing
two‐component
system
MRSA.
It
can
also
induce
macrophage
M1
polarization,
up‐regulate
pro‐inflammatory
factor
tumor
necrosis
factor‐α,
phagocytosis
bacteria.
strategy
provides
insights
into
development
high‐performance
nanocomposites
treatment
in
tissues.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(44)
Опубликована: Авг. 2, 2024
Abstract
Infected
mandibular
defects
pose
a
formidable
challenge
without
an
entirely
satisfactory
repair
strategy.
Here,
coaxial
3D
printing
scaffold
comprising
shell
loaded
is
dveloped
with
the
antibiotic
minocycline
hydrochloride
and
core
wrapped
traditional
Chinese
medicine
antler
powers.
This
study
conducted
to
evaluate
efficacy
of
in
facilitating
infected
defects.
In
vitro
investigations
exhibit
that
this
construct
possesses
porous
microstructure,
exceptional
mechanical
properties,
appropriate
degradability,
acceptable
water
absorption
capacity,
biocompatibility.
Transcriptome
analyses
further
reveal
notable
upregulation
relevant
genes
signaling
pathways
associated
cell
activity,
osteogenesis,
angiogenesis.
vivo
rat
(Φ
=
5
mm)
rabbit
(5
mm
×
4
10
defect
models
confirm
scaffold's
ability
sequentially
regulate
bone
healing
by
suppressing
infection
inflammation,
followed
promoting
osteogenesis
advanced
graft
holds
significant
translational
potential
for
infectious
regeneration.
Journal of Materials Research and Technology,
Год журнала:
2024,
Номер
31, С. 2961 - 2971
Опубликована: Июль 1, 2024
Carbon-based
microwave
absorbing
composites
with
magnetic-dielectric
properties
and
multiple
loss
mechanism
are
considered
to
be
an
effective
choice
for
solving
electromagnetic
pollution.
In
this
paper,
the
PPy/Fe/Fe3O4@C
composite
was
synthesized
from
MIL-101-Fe
derivatives
subsequently
coated
polypyrrole
(PPy)
by
combining
hydrothermal,
high-temperature
pyrolysis
oxidative
polymerization.
The
effects
of
temperature
PPy
loading
on
components,
microstructures
parameters
were
investigated.
results
showed
that
consisted
two-dimensional
carbon
flakes
modified
magnetic
particles
laminated
conductive
polymers.
When
is
moderate,
reaches
a
minimum
reflection
(RLmin)
−61.38
dB
at
3.1
mm
thickness
absorption
bandwidth
(EAB)
5.81
GHz
2.2
mm.
After
pyrolysis,
unique
three-dimensional
structure
sheet
stacking,
as
well
heterogeneous
interface
networks
generated
modification
Fe
Fe3O4
PPy,
beneficial
improve
dielectric
losses
optimize
impedance
matching.
These
polymer-modified
have
potential
development
application
in
absorption.
Abstract
Antibiotics
are
frequently
used
to
clinically
treat
osteomyelitis
caused
by
bacterial
infections.
However,
extended
antibiotic
use
may
result
in
drug
resistance,
which
can
be
life
threatening.
Here,
a
heterojunction
comprising
Fe
2
O
3
/Fe
S
4
magnetic
composite
is
constructed
achieve
short‐term
and
efficient
methicillin‐resistant
Staphylococcus
aureus
(MRSA).
The
exhibits
powerful
microwave
(MW)
absorption
properties,
thereby
effectively
converting
incident
electromagnetic
energy
into
thermal
energy.
Density
functional
theory
calculations
demonstrate
that
possesses
significant
charge
accumulation
oxygen‐fixing
capacity
at
the
heterogeneous
interface,
provides
more
active
sites
oxygen
sources
for
trapping
hotspots.
finite
element
analysis
indicates
displays
larger
electromagnetism
field
enhancement
parameter
than
owing
increase
These
hotspots
contribute
differential
depletion
motions
augmenting
release
of
free
electrons
subsequently
combine
with
adsorbed
generate
reactive
species
(ROS)
heat.
This
research,
achieves
extraordinary
eradication
through
synergistic
effect
therapy
(MWTT)
dynamic
(MDT),
presents
novel
strategy
treating
deep‐tissue
