Tantalum
oxide
nanoparticles
(TaOx
NPs)
are
promising
as
high-Z-contrast
agents
for
computed
tomography
(CT)
due
to
their
profound
imaging
benefits
relative
those
of
clinical
iodinated
contrast
media
(ICM)
at
the
X-ray
tube
voltages
≥100
kVp
required
most
patients.
Furthermore,
TaOx
NPs
have
prevailed
through
extensive
non-GLP
and
GLP
(good
laboratory
practice)
preclinical
development,
including
in
vivo/vitro
safety
testing
efficacy
studies.
This
is
part
innovative
structural
engineering
NPs’
core
size
coating,
which
has
been
shown
provide
favorable
pharmacokinetics
promote
rapid
renal
clearance,
with
negligible
organ
retention.
In
this
study,
a
carboxybetaine
zwitterionic
siloxane
polymer
(CZ)
coating
lead
candidate
NP
thoroughly
characterized
using
multinuclear/multidimensional
nuclear
magnetic
resonance
(NMR)
spectroscopic
techniques.
1H
1H/13C
heteronuclear
multiple
bond
correlation
NMR
spectroscopies
used
confirm
CZ
coating’s
structure,
combination
29Si
NMR,
architecture
bound
surface
described.
Of
particular
significance,
spectra
were
identify
T-region
bonding
modes
show
superiority
diafiltration
over
dialysis
purification
NPs.
Through
spectral
comparison,
cyclic
impurity
product
purified
was
found
be
absent
diafiltration.
Finally,
Carr–Purcell–Meiboom–Gill
(CPMG)
pulse
sequence
novel
manner
probe
distance-dependent
interactions
between
spins
surface.
Biomacromolecules,
Год журнала:
2024,
Номер
25(5), С. 2740 - 2748
Опубликована: Апрель 2, 2024
A
self-immolative
radiocontrast
polymer
agent
has
been
newly
designed
for
this
study.
The
is
composed
of
a
degradable
poly(benzyl
ether)-based
backbone
that
enables
complete
and
spontaneous
depolymerization
upon
exposure
to
specific
stimulus,
with
iodophenyl
pendant
groups
confer
radiodensity
comparable
commercial
agents.
In
particular,
when
incorporated
into
biodegradable
polycaprolactone
matrix,
the
not
only
reinforces
matrix
provides
prolonged
radiopacity
without
leaching
but
also
governs
overall
degradation
kinetics
composite
under
basic
aqueous
conditions,
allowing
X-ray
tracking
exhibiting
predictable
until
end
its
lifespan.
Our
design
would
be
advanced
various
other
components
produce
synergistic
functions
extended
applications
in
implantable
devices
theragnostic
systems.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 25, 2024
Abstract
Locally
advanced
breast
cancer
(LABC)
is
a
heterogeneous
group
of
that
accounts
for
10–30%
cases.
Despite
the
ongoing
development
current
treatment
methods,
LABC
remains
severe
and
complex
public
health
concern
around
world,
thus
prompting
urgent
requirement
innovative
diagnosis
strategies.
The
primary
challenges
are
inoperable
clinical
status
ineffective
local
control
methods.
With
rapid
advancement
nanotechnology,
inorganic
nanoparticles
(INPs)
exhibit
potential
application
prospect
in
diagnosing
treating
cancer.
Due
to
unique
inherent
characteristics
INPs,
different
functions
can
be
performed
via
appropriate
modifications
constructions,
making
them
suitable
imaging
technology
strategies
schemes.
INPs
improve
efficacy
conventional
radiotherapy
treatment.
In
face
LABC,
have
proposed
new
therapeutic
methods
fostered
evolution
novel
such
as
photothermal
photodynamic
therapy,
magnetothermal
sonodynamic
multifunctional
nanoplatform.
This
article
reviews
advances
accurate
offers
insights
overcome
existing
difficulties
management.
Graphical
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 22, 2025
Cerebrovascular
imaging
is
essential
for
the
diagnosis,
treatment,
and
prognosis
of
cerebrovascular
disease,
including
stroke,
aneurysms,
vascular
malformations.
Conventional
techniques
such
as
MRI,
CT,
DSA
ultrasound
have
their
own
strengths
limitations,
particularly
in
terms
resolution,
contrast
safety.
Recent
advances
nanotechnology
offer
new
opportunities
improved
imaging.
Nanomaterials,
metallic
nanoparticles,
magnetic
quantum
dots,
carbon-based
nanomaterials,
polymer
show
great
potential
due
to
unique
physical,
chemical,
biological
properties.
This
review
summarizes
recent
advanced
nanomaterials
applications
various
techniques,
discusses
challenges
future
research
directions.
The
aim
provide
valuable
insights
researchers
facilitate
development
clinical
application
these
innovative
Investigative Radiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Abstract
This
review
provides
a
comprehensive
analysis
of
recent
advancements
in
computed
tomography
(CT)
and
magnetic
resonance
imaging
(MRI)
contrast
media,
offering
critical
evaluation
current
trends
exploring
future
directions
the
field.
New
clinical
developments
within
last
5–8
years
are
considered
as
well
efficacy
safety
aspects.
For
CT,
general
low-
iso-osmolar
iodinated
agents
their
effect
on
renal
thyroid
function
reviewed.
Special
attention
is
given
to
contrast-enhanced
mammography
short
outlook
photon-counting
CT
provided.
MRI,
brief
update
safety,
nephrogenic
systemic
fibrosis
presence
gadolinium
brain
given.
The
2
new
high-relaxivity
gadolinium-based
agents,
gadopiclenol
gadoquatrane
(in
late-stage
development),
highlighted.
also
describes
targeted
superparamagnetic
iron
oxide
particles,
manganese-based
agents.
It
introduces
emerging
field
glymphatic
imaging.
