Recent Developments and Future Perspectives in Magnetic Resonance Imaging and Computed Tomography Contrast Media

Investigative Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract This review provides a comprehensive analysis of recent advancements in computed tomography (CT) and magnetic resonance imaging (MRI) contrast media, offering critical evaluation current trends exploring future directions the field. New clinical developments within last 5–8 years are considered as well efficacy safety aspects. For CT, general low- iso-osmolar iodinated agents their effect on renal thyroid function reviewed. Special attention is given to contrast-enhanced mammography short outlook photon-counting CT provided. MRI, brief update safety, nephrogenic systemic fibrosis presence gadolinium brain given. The 2 new high-relaxivity gadolinium-based agents, gadopiclenol gadoquatrane (in late-stage development), highlighted. also describes targeted superparamagnetic iron oxide particles, manganese-based agents. It introduces emerging field glymphatic imaging.

Language: Английский

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Simultaneous determination of three iodinated contrast media in human plasma by LC/MS-MS and its clinical application

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2025, Volume and Issue: 262, P. 116867 - 116867

Published: April 5, 2025

Language: Английский

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Image quality evaluation of imaging skins, a novel stretchable X-ray detector for intraoperative tumour imaging

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 11, 2025

Language: Английский

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Iodinated contrast media (ICM)-induced thyroid dysfunction: a review of potential mechanisms and clinical management

Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 29, 2025

Language: Английский

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Enhanced sensitivity of spectral CT imaging in vivo by using Ytterbium chelate

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154620 - 154620

Published: Aug. 6, 2024

Language: Английский

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Novel intravascular tantalum oxide-based contrast agent achieves improved vascular contrast enhancement and conspicuity compared to Iopamidol in an animal multiphase CT protocol

European Radiology Experimental, Journal Year: 2024, Volume and Issue: 8(1)

Published: Oct. 4, 2024

Language: Английский

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Innovative applications of advanced nanomaterials in cerebrovascular imaging

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 22, 2025

Cerebrovascular imaging is essential for the diagnosis, treatment, and prognosis of cerebrovascular disease, including stroke, aneurysms, vascular malformations. Conventional techniques such as MRI, CT, DSA ultrasound have their own strengths limitations, particularly in terms resolution, contrast safety. Recent advances nanotechnology offer new opportunities improved imaging. Nanomaterials, metallic nanoparticles, magnetic quantum dots, carbon-based nanomaterials, polymer show great potential due to unique physical, chemical, biological properties. This review summarizes recent advanced nanomaterials applications various techniques, discusses challenges future research directions. The aim provide valuable insights researchers facilitate development clinical application these innovative

Language: Английский

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Dendrimers as Versatile Platforms for Advanced Biosensor Development: A Review on Chemistry, Synthesis, and Performance Enhancements

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 116365 - 116365

Published: April 1, 2025

Language: Английский

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Real-Time in Vivo Bacterial Imaging by Computed Tomography and Fluorescence Using Phage-Gold Nanorod Bioconjugates as Contrast Agents

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Real-time in vivo imaging of bacterial infections is an important goal to aid the study and treatment infections. Phages can be genetically engineered ensure a particular biomolecular target specificity, gold nanomaterials conjugated phages for variety applications including biosensing. In this paper, we describe methods use phage-gold nanorod conjugates detection species Pseudomonas aeruginosa mice. The modalities are computed tomography (CT), using as contrast agent, fluorescence, which applied when FDA-approved near-infrared (NIR) dye indocyanine green (ICG) also chemically cross-linked bioconjugates. addition, rapid protocols validating bioconjugate synthesis initial assessment toxicity given. example, probe shown specifically highlight P. without cross-reactivity another Gram-negative organism (V. cholerae) appears biocompatible. Phage-directed probes may thus useful characterization diagnosis

Language: Английский

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Advances in Ultrasmall Inorganic Nanoparticles for Nanomedicine: From Diagnosis to Therapeutics

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Inorganic nanoparticles possess unique physicochemical properties that make them attractive candidates for diverse applications in nanomedicine, including as contrast agents and therapeutics. However, many inorganic are composed of high-atomic-number elements, raising safety concerns due to potential long-term retention the body. ultrasmall (UINPs), i.e., those less than ∼5 nm diameter, can offer advantage rapid renal clearance from body, reducing toxicity risks associated with prolonged exposure thereby creating a path toward clinical translation. In this review, we discuss current knowledge on design functionalization UINPs, exploring their capabilities diagnosis therapeutics, examples radiosensitization, photothermal, anti-inflammatory catalytic therapies. addition, limitations, approaches taken solve progress UINPs Through discussion, aim provide comprehensive perspective how advancing field underscoring significantly improve bioimaging therapeutic outcomes.

Language: Английский

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