Recent advances in nanomaterials and their mechanisms for infected wounds management

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101553 - 101553

Опубликована: Фев. 5, 2025

Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient

Язык: Английский

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Harnessing in vitro cytotoxicity and antibacterial potential of a novel silver-DABCO framework against multi-drug-resistant pathogens

RSC Advances, Год журнала: 2025, Номер 15(11), С. 8180 - 8188

Опубликована: Янв. 1, 2025

This study aimed to synthesize and characterize silver-based metal–organic frameworks (Ag-MOFs) using 1,4-diazabicyclo[2.2.2]octane (DABCO) as the organic ligand assess their antibacterial cytotoxic properties.

Язык: Английский

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Acid‐Responsive Bacteria‐Targeted Zinc‐Porphyrin Based Sonosensitizer with Enhancing Antibacterial Efficacy and Biofilm Eradication for Infected Wounds Healing

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

Abstract Diseases caused by bacterial infections place a significant burden on global public health. Sonodynamic therapy (SDT), as an emerging antibacterial treatment, faces clinical challenges due to the non‐polar nature of most sonosensitizers. To address this, acid‐responsive zinc‐porphyrin‐based sonosensitizer (Zn‐TCPP) is developed via simple thermal reaction, which then coated with phenylboronic acid‐modified hyaluronic acid (B‐HA), fabricate B‐HA@Zn‐TCPP. While in mildly acidic microenvironment mimicking infected wound site, released B‐HA@Zn‐TCPP achieves effective SDT activity. The disruption membrane and levels intracellular reactive oxygen species (ROS) verified that inhibition rate can reach 99% within 5 min, without any development resistance after 15 consecutive generations culture. Additionally, under ultrasound (US) ‐mediated cavitation, exhibits excellent penetration into biofilms, achieving 90.04% bactericidal for bacteria biofilms. In vivo studies further demonstrated effectively accelerate healing wounds 98.65% 9 days. Therefore, novel offers viable strategy overcome limitations traditional sonosensitizers infections.

Язык: Английский

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Solar radiation–promoted selective photocatalytic degradation of Congo red dye by a novel amorphous Cr-based metal-organic framework serving as sensor for 2,4,6-trinitrophenol explosive detection

Environmental Monitoring and Assessment, Год журнала: 2025, Номер 197(3)

Опубликована: Фев. 25, 2025

Язык: Английский

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Beyond the Swipe: A Review of Photocatalytic Antimicrobial Biocompatible Touchscreen Technology

Applied Materials Today, Год журнала: 2025, Номер 44, С. 102697 - 102697

Опубликована: Март 30, 2025

Язык: Английский

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Metal-organic framework-based materials: From synthesis and characterization routes to electrochemical sensing applications

Coordination Chemistry Reviews, Год журнала: 2025, Номер 536, С. 216680 - 216680

Опубликована: Апрель 10, 2025

Язык: Английский

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Mannosylated MOF Encapsulated in Lactobacillus Biofilm for Dual‐Targeting Intervention Against Mammalian Escherichia coli Infections

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Abstract Pathogenic bacterial infections pose a major concern, especially concerning mammalian enteritis and diarrhea. Compared to conventional antibiotic intervention, metal–organic frameworks (MOFs) exhibit superior antibacterial properties lower cytotoxicity, demonstrating great promise in the treatment of pathogen‐induced However, achievement their precise targeted delivery is still significant challenge. Herein, novel precision nano‐system with dual‐targeting approach for treating intestinal caused by Escherichia coli (E. coli) designed. First, Zn‐MOF was synthesized based on ZnO, which possessed enhanced elimination planktonic bacteria biofilms. Through mannosylation, Zn‐MOF@Man specifically recognized FimH pili E. , leading its aggregation subsequent eradication. Second, guided whole genome sequencing, encapsulation Lactobacillus biofilm exertd immunomodulatory function, overcomed challenges related targeting, facilitated sustained drug release. Furthermore, Zn‐MOF@Man/LRB maintaind microbiota equilibrium promoted stem cell differentiation barrier stability, ensuring consistent anti‐diarrheal anti‐inflammatory efficacy mice, piglets, humans. This represents antimicrobial strategy, combining probiotic biofilms ‐oriented delivery, advancing safe effective that restores homeostasis potential applications both human medicine animal husbandry.

Язык: Английский

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Metal‐Organic Framework‐Based Antimicrobial Touch Surfaces to Prevent Cross‐Contamination

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Май 21, 2024

Infection diseases are a major threat to global public health, with nosocomial infections being of particular concern. In this context, antimicrobial coatings emerge as promising prophylactic strategy reduce the transmission pathogens and control infections. Here, door handle covers prevent cross-contamination prepared by incorporating iodine-loaded UiO-66 microparticles into potentially biodegradable polyurethane polymer (Baycusan eco E 1000). These incorporate MOF particles that serve both storage reservoirs delivery systems for biocidal iodine. Under realistic touching conditions, completely inhibit Gram-positive bacterial species (Staphylococcus aureus, Enterococcus faecalis), Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii), fungi (Candida albicans). The remain effective even after undergoing multiple contamination cycles, cleaned, when tinted improve discretion usability. Furthermore, release iodine from follow hindered Fickian diffusion, their lifetime is calculated be long approximately two years. Together, these results demonstrate potential cross-contamination, underline efficacy integrating MOFs innovative technologies.

Язык: Английский

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Antibacterial Activity of M-MOF Nanomaterials (M = Fe, Co, Ni, Cu, and Zn): Impact of Metal Centers

ACS Applied Nano Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 20, 2024

Язык: Английский

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Targeting starvation therapy for diabetic bacterial infections with endogenous enzyme-triggered hyaluronan-modified nanozymes in the infection microenvironment

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 270, С. 132277 - 132277

Опубликована: Май 10, 2024

Язык: Английский

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