TPP
was
combined
with
ZIF-8,
to
construct
ZIF-8@TPP,
treat
atherosclerosis.
This
nanoplatform
showed
excellent
anti-atherosclerotic
effect
in
vivo
mainly
by
inhibiting
lipid
phagocytosis
of
macrophages
via
downregulating
the
PI3K/AKT/MSR1
pathway.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101553 - 101553
Опубликована: Фев. 5, 2025
Wounds
infected
by
bacteria
pose
a
considerable
challenge
in
the
field
of
healthcare,
particularly
with
increasing
prevalence
antibiotic-resistant
pathogens.
Traditional
antibiotics
often
fail
to
achieve
effective
results
due
limited
penetration,
resistance
development,
and
inadequate
local
concentration
at
wound
sites.
These
limitations
necessitate
exploration
alternative
strategies
that
can
overcome
drawbacks
conventional
therapies.
Nanomaterials
have
emerged
as
promising
solution
for
tackling
bacterial
infections
facilitating
healing,
thanks
their
distinct
physicochemical
characteristics
multifunctional
capabilities.
This
review
highlights
latest
developments
nanomaterials
demonstrated
enhanced
antibacterial
efficacy
improved
healing
outcomes.
The
mechanisms
are
varied,
including
ion
release,
chemodynamic
therapy,
photothermal/photodynamic
electrostatic
interactions,
delivery
drugs,
which
not
only
combat
but
also
address
challenges
posed
biofilms
antibiotic
resistance.
Furthermore,
these
create
an
optimal
environment
tissue
regeneration,
promoting
faster
closure.
By
leveraging
unique
attributes
nanomaterials,
there
is
significant
opportunity
revolutionize
management
wounds
markedly
improve
patient
RSC Advances,
Год журнала:
2025,
Номер
15(11), С. 8180 - 8188
Опубликована: Янв. 1, 2025
This
study
aimed
to
synthesize
and
characterize
silver-based
metal–organic
frameworks
(Ag-MOFs)
using
1,4-diazabicyclo[2.2.2]octane
(DABCO)
as
the
organic
ligand
assess
their
antibacterial
cytotoxic
properties.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
Abstract
Diseases
caused
by
bacterial
infections
place
a
significant
burden
on
global
public
health.
Sonodynamic
therapy
(SDT),
as
an
emerging
antibacterial
treatment,
faces
clinical
challenges
due
to
the
non‐polar
nature
of
most
sonosensitizers.
To
address
this,
acid‐responsive
zinc‐porphyrin‐based
sonosensitizer
(Zn‐TCPP)
is
developed
via
simple
thermal
reaction,
which
then
coated
with
phenylboronic
acid‐modified
hyaluronic
acid
(B‐HA),
fabricate
B‐HA@Zn‐TCPP.
While
in
mildly
acidic
microenvironment
mimicking
infected
wound
site,
released
B‐HA@Zn‐TCPP
achieves
effective
SDT
activity.
The
disruption
membrane
and
levels
intracellular
reactive
oxygen
species
(ROS)
verified
that
inhibition
rate
can
reach
99%
within
5
min,
without
any
development
resistance
after
15
consecutive
generations
culture.
Additionally,
under
ultrasound
(US)
‐mediated
cavitation,
exhibits
excellent
penetration
into
biofilms,
achieving
90.04%
bactericidal
for
bacteria
biofilms.
In
vivo
studies
further
demonstrated
effectively
accelerate
healing
wounds
98.65%
9
days.
Therefore,
novel
offers
viable
strategy
overcome
limitations
traditional
sonosensitizers
infections.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 25, 2025
Abstract
Pathogenic
bacterial
infections
pose
a
major
concern,
especially
concerning
mammalian
enteritis
and
diarrhea.
Compared
to
conventional
antibiotic
intervention,
metal–organic
frameworks
(MOFs)
exhibit
superior
antibacterial
properties
lower
cytotoxicity,
demonstrating
great
promise
in
the
treatment
of
pathogen‐induced
However,
achievement
their
precise
targeted
delivery
is
still
significant
challenge.
Herein,
novel
precision
nano‐system
with
dual‐targeting
approach
for
treating
intestinal
caused
by
Escherichia
coli
(E.
coli)
designed.
First,
Zn‐MOF
was
synthesized
based
on
ZnO,
which
possessed
enhanced
elimination
planktonic
bacteria
biofilms.
Through
mannosylation,
Zn‐MOF@Man
specifically
recognized
FimH
pili
E.
,
leading
its
aggregation
subsequent
eradication.
Second,
guided
whole
genome
sequencing,
encapsulation
Lactobacillus
biofilm
exertd
immunomodulatory
function,
overcomed
challenges
related
targeting,
facilitated
sustained
drug
release.
Furthermore,
Zn‐MOF@Man/LRB
maintaind
microbiota
equilibrium
promoted
stem
cell
differentiation
barrier
stability,
ensuring
consistent
anti‐diarrheal
anti‐inflammatory
efficacy
mice,
piglets,
humans.
This
represents
antimicrobial
strategy,
combining
probiotic
biofilms
‐oriented
delivery,
advancing
safe
effective
that
restores
homeostasis
potential
applications
both
human
medicine
animal
husbandry.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 21, 2024
Infection
diseases
are
a
major
threat
to
global
public
health,
with
nosocomial
infections
being
of
particular
concern.
In
this
context,
antimicrobial
coatings
emerge
as
promising
prophylactic
strategy
reduce
the
transmission
pathogens
and
control
infections.
Here,
door
handle
covers
prevent
cross-contamination
prepared
by
incorporating
iodine-loaded
UiO-66
microparticles
into
potentially
biodegradable
polyurethane
polymer
(Baycusan
eco
E
1000).
These
incorporate
MOF
particles
that
serve
both
storage
reservoirs
delivery
systems
for
biocidal
iodine.
Under
realistic
touching
conditions,
completely
inhibit
Gram-positive
bacterial
species
(Staphylococcus
aureus,
Enterococcus
faecalis),
Gram-negative
(Escherichia
coli,
Pseudomonas
aeruginosa,
Acinetobacter
baumannii),
fungi
(Candida
albicans).
The
remain
effective
even
after
undergoing
multiple
contamination
cycles,
cleaned,
when
tinted
improve
discretion
usability.
Furthermore,
release
iodine
from
follow
hindered
Fickian
diffusion,
their
lifetime
is
calculated
be
long
approximately
two
years.
Together,
these
results
demonstrate
potential
cross-contamination,
underline
efficacy
integrating
MOFs
innovative
technologies.