Antimicrobial peptide biological activity, delivery systems and clinical translation status and challenges
Sainan Zheng,
Yuhan Tu,
Bin Li
и другие.
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 7, 2025
Antibiotic
resistance
is
currently
one
of
the
most
significant
threats
to
global
public
health
and
safety.
And
studies
have
found
that
over
next
25
years,
39
million
people
will
die
directly
169
indirectly
due
antibiotic-resistant
diseases.
Consequently,
development
new
types
antimicrobial
drugs
urgently
needed.
Antimicrobial
peptides
(AMPs)
constitute
an
essential
component
innate
immune
response
in
all
organisms.
They
exhibit
a
distinctive
mechanism
action
endows
them
with
broad
spectrum
biological
activities,
including
antimicrobial,
antibiofilm,
antiviral,
anti-inflammatory
effects.
However,
AMPs
also
present
certain
limitations,
such
as
cytotoxicity,
susceptibility
protein
hydrolysis,
poor
pharmacokinetic
properties,
which
impeded
their
clinical
application.
The
delivery
systems
can
address
these
challenges
by
modifying
AMP
enabling
precise,
controlled
release
at
site
infection
or
disease.
This
review
offers
comprehensive
analysis
mechanisms
advantages
AMPs.
systematically
evaluate
how
emerging
drug
systems,
nanoparticles
hydrogels,
enhance
stability
bioavailability
AMPs,
discussing
both
strengths
limitations.
Moreover,
unlike
previous
reviews,
this
highlight
recent
clinically
approved
AMP-based
those
development,
emphasizing
key
translating
into
practice.
With
perspectives,
it
hoped
provide
some
insights
overcoming
translational
barriers
advancing
Язык: Английский
A Cell Adhesive Radial Nanofiber Membrane for Promoting Diabetes Wound Healing
ACS Applied Polymer Materials,
Год журнала:
2024,
Номер
7(1), С. 258 - 267
Опубликована: Дек. 27, 2024
Diabetic
wounds
are
extremely
difficult
to
heal
due
the
long
duration
and
high
recurrence
rate.
The
bacterial
infection
caused
by
elevated
blood
glucose
negatively
affects
speed
of
wound
healing.
In
this
article,
radially
oriented
nanofibers
containing
natural
antimicrobial
agent
purslane
were
prepared
electrostatic
spinning.
Subsequently,
asiaticoside
was
loaded
onto
surface
fibers
spraying.
experimental
results
indicated
that
radial
nanofiber
membranes
exhibited
uniform
diameter
distribution,
suitable
water
vapor
permeability,
good
hydrophilicity
as
well
excellent
antibacterial
performance
biocompatibility.
Due
ordered
arrangement,
healing
ability,
regular
granulation
tissue
growth,
collagen
deposition.
More
importantly,
fiber
structure
significantly
promoted
cell
proliferation
adhesion.
Based
on
these
results,
with
a
have
potential
application
prospects
in
field
chronic
diabetic
Язык: Английский