Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 703, С. 135176 - 135176
Опубликована: Авг. 24, 2024
Язык: Английский
Regenerative Biomaterials, Год журнала: 2024, Номер 11
Опубликована: Янв. 1, 2024
In recent years, the regulation of cell microenvironment has opened up new avenues for bone defect repair. Researchers have developed novel biomaterials to influence behavior osteoblasts and immune cells by regulating microenvironment, aiming achieve efficient Mitochondria, as crucial organelles involved in energy conversion, biosynthesis signal transduction, play a vital role maintaining integrity. Dysfunction mitochondria can detrimental effects on transformation differentiation stem cells, thereby hindering tissue regeneration. Consequently, targeted therapy strategies focusing emerged. This approach offers wide range applications reliable therapeutic effects, providing treatment option complex refractory diseases. studies, more been used restore mitochondrial function promote positive differentiation. The main directions are metabolism, biogenesis quality control. this review, we investigated mitochondria-targeted repair years from perspective progress strategies. We also summarized micro-molecular mechanisms affected them. Through discussions oxidative stress autophagy regulation, emphasized opportunities challenges faced biomaterials, clues developing generation materials.
Язык: Английский
Процитировано
3
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 29, 2025
Coating biological membranes onto biomimetic nanocarriers improves biocompatibility, prolongs circulation, and enhances targeted delivery for cancer precision medicine. To better understand the biodistribution profiles of these nanosystems, molecular imaging techniques, including optical imaging, radionuclide magnetic resonance ultrasound have been widely employed in vivo tracking dynamic imaging. Here this review, we delve into profound role modalities visualizing changes tumor microenvironment, particularly monitoring oxygen consumption immune response dynamics, highlighting their potential to improve therapies. We also briefly discuss current applications synergistic therapies future perspectives. Finally, offer insights integrating nanomedicine with clinical translation.
Язык: Английский
Процитировано
0
Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)
Опубликована: Фев. 4, 2025
Hair loss has long been a significant concern for many individuals. Recent studies have indicated that mitochondria play more crucial role in hair than previously recognized. This review summarizes the connection between mitochondrial dysfunction and follicle development, outlines links diseases related to disorders issues, highlights influence of on androgenetic alopecia. We discuss cellular signaling mechanisms associated with examine how dysfunction, such as insufficient energy supply, irregularities, protein/gene abnormalities, programmed cell death, can hinder normal proliferation, differentiation, growth cells. Furthermore, we current treatment approaches potential innovative therapies, including mitochondrion-targeting drugs advanced techniques directly target cells, providing fresh insights into maintaining health managing disorders. this explores future therapeutic strategies proposes research could lead groundbreaking treatments loss, thus optimism new avenues individuals experiencing loss. not only underscores central importance but also emphasizes advancing field.
Язык: Английский
Процитировано
0
Polymer science & technology., Год журнала: 2025, Номер unknown
Опубликована: Апрель 30, 2025
Язык: Английский
Процитировано
0
Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Май 20, 2025
Mitochondria-targeted delivery is a promising strategy in anticancer drug development. Triphenylphosphine cation (TPP+) the most widely used mitochondrial-targeting carrier due to elevated mitochondrial membrane potential (MMP) cancer cells. Here, we report serendipitous discovery of carrier, compound 23, which exhibited potent activity (IC50 = 70 nM, HCC827) with minimal toxicity normal Compound 23 selectively accumulates cell mitochondria, induces MMP depolarization, and activates mitophagy via PINK1-Parkin pathway. It also disruptes functions, elevates ROS levels, inhibits xCT-GSH-GPX4 axis, leading lipid peroxidation ferroptotic death. In vivo, significantly suppressed growth HCC827 xenograft tumors at 10 mg/kg. These findings support as highly selective effective agent for further investigation.
Язык: Английский
Процитировано
0
Current Pharmaceutical Design, Год журнала: 2024, Номер 30(10), С. 727 - 741
Опубликована: Март 1, 2024
Abstract: This review investigates the revolutionary application of cell membrane-coated nanoparticles (CMNPs) as a promising avenue for cancer therapy within embryonic landscape nanotechnology. Nanoparticles, pivotal in treatment, are systematically examined their diverse physicochemical structures, categorized organic (lipid-based, protein-based, and polymer-assisted) inorganic (carbon-based metal) varieties. A significant focus is placed on CMNPs, which serve an innovative drug delivery vehicle, overcoming limitations associated with conventional nanoparticle therapies. manuscript accurately explores advantages challenges various membranes, including those derived from cells, red blood platelets, stem white cells. Importance roles enhancing precision, immune system circumvention, targeted recognition. Detailed insights into crafting CMNPs provided, elucidating membrane extraction fusion techniques, such sonication, extrusion, co-extrusion, microfluidic electroporation. Maintaining integrity during benefits coating techniques augmenting biocompatibility underscored. comprehensive resource consolidates latest advancements delivery, positioning itself at forefront nanotechnology biomedicine research. Encapsulating methodologies like electrospray, chemical conjugation, this showcases expanding toolbox available to researchers dynamic field. Focusing unique characteristics multifaceted applications biomedical research, particularly tumour therapy. It provides indepth analysis stability, evasion capabilities, increased payload capacity, retained biological functionality. The outlines current future prospects chemotherapy, photothermal photodynamic therapy, immunotherapy, gene therapeutic methods. concludes by highlighting transformative potential reshaping treatment.
Язык: Английский
Процитировано
2
Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 703, С. 135176 - 135176
Опубликована: Авг. 24, 2024
Язык: Английский
Процитировано
1