Noble Metal Nanoparticle-Based Photothermal Therapy: Development and Application in Effective Cancer Therapy
Shujie Yu,
Guoyu Xia,
Nan Yang
и другие.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 5632 - 5632
Опубликована: Май 22, 2024
Photothermal
therapy
(PTT)
is
a
promising
cancer
modality
with
significant
advantages
such
as
precise
targeting,
convenient
drug
delivery,
better
efficacy,
and
minimal
adverse
effects.
effectively
absorbs
the
photothermal
transducers
in
near-infrared
region
(NIR),
which
induces
effect
to
work.
Although
PTT
has
role
tumor
therapy,
it
also
suffers
from
low
conversion
efficiency,
biosafety,
incomplete
elimination.
Therefore,
use
of
nanomaterials
themselves
photosensitizers,
targeted
modification
improve
targeting
or
combined
other
therapies
can
therapeutic
effects
reduce
side
Notably,
noble
metal
have
attracted
much
attention
because
they
strong
surface
plasmon
resonance
an
effective
absorbance
light
at
specific
wavelengths.
be
used
excellent
photosensitizers
mediate
its
efficiency.
This
paper
provides
comprehensive
review
key
played
by
therapy.
It
describes
major
challenges
encountered
during
implementation
Язык: Английский
Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Nanozymes
have
shown
significant
potential
in
cancer
catalytic
therapy
by
strategically
catalyzing
tumor-associated
substances
and
metabolites
into
toxic
reactive
oxygen
species
(ROS)
situ,
thereby
inducing
oxidative
stress
promoting
cell
death.
However,
within
the
complex
tumor
microenvironment
(TME),
rational
design
of
nanozymes
factors
like
activity,
reaction
substrates,
TME
itself
significantly
influence
efficiency
ROS
generation.
To
address
these
limitations,
recent
research
has
focused
on
exploring
that
affect
activity
developing
nanozyme-based
cascade
systems,
which
can
trigger
two
or
more
processes
tumors,
producing
therapeutic
achieving
efficient
stable
with
minimal
side
effects.
This
area
remarkable
progress.
Perspective
provides
a
comprehensive
overview
nanozymes,
covering
their
classification
fundamentals.
The
regulation
nanozyme
strategies
are
discussed
detail.
Furthermore,
representative
paradigms
for
successful
construction
systems
treatment
summarized
focus
revealing
underlying
mechanisms.
Finally,
we
current
challenges
future
prospects
development
biomedical
applications.
Язык: Английский
NIR-II cascade-driven synergistic photodynamic and photothermal cancer therapies via 5-aminolevulinic acid-functionalized titanium carbide hexagonal nanorods
FlatChem,
Год журнала:
2025,
Номер
unknown, С. 100826 - 100826
Опубликована: Янв. 1, 2025
Язык: Английский
Eu-Ce Commensalism: A Dual-Functional Nanozyme with Enhanced Peroxidase-like Activity for the Ultrasensitive and Specific Detection of Phosphate Ions
Sensors and Actuators B Chemical,
Год журнала:
2025,
Номер
unknown, С. 137695 - 137695
Опубликована: Март 1, 2025
Язык: Английский
Imprinted membrane-covalent organic framework platform for efficient label-free visual detection of Listeria monocytogenes and Salmonella typhimurium in food samples
Analytica Chimica Acta,
Год журнала:
2024,
Номер
1320, С. 343002 - 343002
Опубликована: Июль 23, 2024
Язык: Английский
Ultrasmall gold-encapsulated mesoporous platinum to promote photodynamic/catalytic therapy through cascade enzyme-like reactions
Journal of Colloid and Interface Science,
Год журнала:
2024,
Номер
680, С. 117 - 128
Опубликована: Ноя. 3, 2024
Язык: Английский
Applications of Nanotheranostic in the Second Near-Infrared Window in Bioimaging and Cancer Treatment
Nanoscale,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Achieving
accurate
and
efficient
tumor
imaging
is
crucial
in
the
field
of
treatment,
as
it
facilitates
early
detection
precise
localization
tissues,
thereby
informing
therapeutic
strategies
surgical
interventions.
The
optical
technology
within
second
near-infrared
(NIR-II)
window
has
garnered
significant
interest
for
its
remarkable
benefits,
such
enhanced
tissue
penetration
depth,
superior
signal-to-background
ratio
(SBR),
minimal
autofluorescence,
reduced
photon
attenuation,
lower
scattering.
This
review
explained
design
optimization
nano-agents
responsive
to
NIR-II
window,
single-walled
carbon
nanotubes,
quantum
dots,
lanthanum-based
nanomaterials,
noble
metal
nanomaterials.
These
enable
non-invasive,
deep-tissue
with
high
spatial
resolution
their
properties
significantly
improve
accuracy,
efficiency,
versatility
imaging-guided
treatments.
And
we
discussed
characteristics
advantages
fluorescence
(FL)/photoacoustic
(PA)
providing
a
comprehensive
overview
latest
research
progress
different
FL/PA
therapy.
Furthermore,
exhaustively
reviewed
applications
multifunctional
nano-phototherapy
technologies
carried
out
by
light
including
photothermal
therapy
(PTT),
photodynamic
(PDT),
combined
modalities
like
photothermal-chemodynamic
(PTT-CDT),
photothermal-chemotherapy
(PTT-CT),
photothermal-
immunotherapy
(PTT-IO).
integrated
approaches
have
gradually
matured
over
past
decade
are
expected
become
safe
effective
non-invasive
treatment.
Finally,
outlined
prospects
challenges
development
innovation
diagnosis
nanoplatform.
aims
provide
insightful
perspectives
future
advancements
treatment
platforms.
Язык: Английский
Multifaceted Role of Nanocomposite Hydrogels in Diabetic Wound Healing: Enhanced Biomedical Applications and Detailed Molecular Mechanisms
Biomaterials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Nanocomposite
hydrogels
offer
a
promising
approach
to
treating
diabetic
wounds.
Key
findings
include
enhanced
mechanical
properties,
antibacterial
effects,
and
the
ability
regulate
wound
microenvironment.
Язык: Английский
Multifunctional Polyoxovanadate-Based Covalent Organic Polymer for Bacteria-Infected Wound Therapy
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 27, 2024
The
special
pathological
microenvironment
of
infected
wounds
(pathology
weakly
acidic,
hypoxic,
and
overexpressed
H2O2)
provides
fertile
soil
for
the
development
disease.
Tailoring
treatment
based
on
specific
characteristics
infectious
(IME)
has
emerged
as
a
novel
direction
in
antimicrobial
therapies.
Here,
polyoxovanadate
(POV)-based
covalent
organic
polymer
(POV-Fc-COP)
with
inherent
photothermal
activity
was
facilely
prepared
via
copolymerization
1,1′-bi(3-dimethylamino-1-oxo-2-enyl-ferrocene)
(BDOEF)
tris-NH2-modified
POV
(tris-V6O9),
which
nanovanadium
oxide
(V2O3
V2O5)
core
shell
were
generated
directly
during
Michael
addition–elimination
reaction.
unique
structure
composition
impart
pH-responsive
peroxidase-like
(POD-like)
catalase-like
(CAT-like)
activities,
concurrently,
to
POV-Fc-COP.
Specifically,
acid-activated
mimicking-POD
could
consume
H2O2
microenvironment,
producing
toxic
•OH
combat
bacteria
biofilms.
vanadium
consumes
excessive
acid,
resulting
an
increase
pH.
Meanwhile,
CAT-like
transform
excess
expression
into
O2
relieve
hypoxia
induced
by
damage
blood
vessels
facilitate
wound
healing.
Additionally,
synergistic
amplified
therapeutic
effect
triggered
application
laser
irradiation
facilitates
rapid
eradication
biofilm,
minimizing
detrimental
impacts
bacterial
proliferation
IME,
thereby
accelerating
restoration
IME
return
normal
state.
Therefore,
POV-Fc-COP
dual-enzyme
functionality
not
only
utilize
but
also
regulate
significantly
expediting
healing
bacteria-infected
wounds.
This
study
demonstrates
simple
method
preparation
intelligent
platform
programmed
antibacterial
antibiofilm
formation,
thus
promoting
while
utilizing
improving
IME.
Язык: Английский
Biomineralization of Bi2S3-Gd2O3 nanocomposites: a novel approach for enhanced photothermal and MRI applications
Digest Journal of Nanomaterials and Biostructures,
Год журнала:
2024,
Номер
19(4), С. 1903 - 1920
Опубликована: Дек. 15, 2024
In
this
study,
Bi2S3-Gd2O3
nanocomposites
(Bi2S3-Gd2O3@BSA)
were
prepared
via
biomineralization
using
albumin
as
a
template,
and
the
nanomaterials
directed
to
tumor
site
through
surface
folic
acid
modification.
Among
these
materials,
Bi2S3
serves
an
effective
photothermal
conversion
agent
(PTA)
for
therapy
at
sites,
attributed
its
impressive
efficiency.
contrast,
Gd2O3,
being
paramagnetic
substance,
can
serve
effectively
contrast
in
magnetic
resonance
imaging
(MRI).
According
vitro
vivo
experiments,
exhibit
low
toxicity,
favorable
biocompatibility,
outstanding
properties.
Upon
exposure
808
nm
laser
irradiation,
quickly
reach
therapeutic
temperature
necessary
treatment.
With
modification,
accumulate
region,
enabling
efficient
This
strategy
provides
fresh
outlook
purposeful
design
of
diagnostic
agents
aimed
therapy.
Язык: Английский