Biomineralization of Bi2S3-Gd2O3 nanocomposites: a novel approach for enhanced photothermal and MRI applications DOI Creative Commons
Qiang Lu,

B. H. Zhang,

Ting‐Hua Yi

et al.

Digest Journal of Nanomaterials and Biostructures, Journal Year: 2024, Volume and Issue: 19(4), P. 1903 - 1920

Published: Dec. 15, 2024

In this study, Bi2S3-Gd2O3 nanocomposites (Bi2S3-Gd2O3@BSA) were prepared via biomineralization using albumin as a template, and the nanomaterials directed to tumor site through surface folic acid modification. Among these materials, Bi2S3 serves an effective photothermal conversion agent (PTA) for therapy at sites, attributed its impressive efficiency. contrast, Gd2O3, being paramagnetic substance, can serve effectively contrast in magnetic resonance imaging (MRI). According vitro vivo experiments, exhibit low toxicity, favorable biocompatibility, outstanding properties. Upon exposure 808 nm laser irradiation, quickly reach therapeutic temperature necessary treatment. With modification, accumulate region, enabling efficient This strategy provides fresh outlook purposeful design of diagnostic agents aimed therapy.

Language: Английский

Noble Metal Nanoparticle-Based Photothermal Therapy: Development and Application in Effective Cancer Therapy DOI Open Access

Shujie Yu,

Guoyu Xia,

Nan Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5632 - 5632

Published: May 22, 2024

Photothermal therapy (PTT) is a promising cancer modality with significant advantages such as precise targeting, convenient drug delivery, better efficacy, and minimal adverse effects. effectively absorbs the photothermal transducers in near-infrared region (NIR), which induces effect to work. Although PTT has role tumor therapy, it also suffers from low conversion efficiency, biosafety, incomplete elimination. Therefore, use of nanomaterials themselves photosensitizers, targeted modification improve targeting or combined other therapies can therapeutic effects reduce side Notably, noble metal have attracted much attention because they strong surface plasmon resonance an effective absorbance light at specific wavelengths. be used excellent photosensitizers mediate its efficiency. This paper provides comprehensive review key played by therapy. It describes major challenges encountered during implementation

Language: Английский

Citations

18
Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy DOI

Xiuna Jia,

Erkang Wang, Jin Wang

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Language: Английский

Citations

3
NIR-II cascade-driven synergistic photodynamic and photothermal cancer therapies via 5-aminolevulinic acid-functionalized titanium carbide hexagonal nanorods DOI

Wu Yanlin,

Jingjing Zhang, Abdul Wahab

et al.

FlatChem, Journal Year: 2025, Volume and Issue: unknown, P. 100826 - 100826

Published: Jan. 1, 2025

Language: Английский

Citations

0
Eu-Ce Commensalism: A Dual-Functional Nanozyme with Enhanced Peroxidase-like Activity for the Ultrasensitive and Specific Detection of Phosphate Ions DOI
Binyang Yuan,

Chunyuan Tang,

Lijun Luo

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137695 - 137695

Published: March 1, 2025

Language: Английский

Citations

0
Imprinted membrane-covalent organic framework platform for efficient label-free visual detection of Listeria monocytogenes and Salmonella typhimurium in food samples DOI
Yuanyuan Guo, Hongqian Cao,

Wenli Di

et al.

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1320, P. 343002 - 343002

Published: July 23, 2024

Language: Английский

Citations

1
Ultrasmall gold-encapsulated mesoporous platinum to promote photodynamic/catalytic therapy through cascade enzyme-like reactions DOI
Tianyou Wang, Tao Liu, Zekai Li

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 680, P. 117 - 128

Published: Nov. 3, 2024

Language: Английский

Citations

1
Applications of Nanotheranostic in the Second Near-Infrared Window in Bioimaging and Cancer Treatment DOI
Huimin Li, Pengju Li, Jiarui Zhang

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Achieving accurate and efficient tumor imaging is crucial in the field of treatment, as it facilitates early detection precise localization tissues, thereby informing therapeutic strategies surgical interventions. The optical technology within second near-infrared (NIR-II) window has garnered significant interest for its remarkable benefits, such enhanced tissue penetration depth, superior signal-to-background ratio (SBR), minimal autofluorescence, reduced photon attenuation, lower scattering. This review explained design optimization nano-agents responsive to NIR-II window, single-walled carbon nanotubes, quantum dots, lanthanum-based nanomaterials, noble metal nanomaterials. These enable non-invasive, deep-tissue with high spatial resolution their properties significantly improve accuracy, efficiency, versatility imaging-guided treatments. And we discussed characteristics advantages fluorescence (FL)/photoacoustic (PA) providing a comprehensive overview latest research progress different FL/PA therapy. Furthermore, exhaustively reviewed applications multifunctional nano-phototherapy technologies carried out by light including photothermal therapy (PTT), photodynamic (PDT), combined modalities like photothermal-chemodynamic (PTT-CDT), photothermal-chemotherapy (PTT-CT), photothermal- immunotherapy (PTT-IO). integrated approaches have gradually matured over past decade are expected become safe effective non-invasive treatment. Finally, outlined prospects challenges development innovation diagnosis nanoplatform. aims provide insightful perspectives future advancements treatment platforms.

Language: Английский

Citations

0
Multifaceted Role of Nanocomposite Hydrogels in Diabetic Wound Healing: Enhanced Biomedical Applications and Detailed Molecular Mechanisms DOI

Gege Xiong,

Qiwei Chen, Qiuyu Wang

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Nanocomposite hydrogels offer a promising approach to treating diabetic wounds. Key findings include enhanced mechanical properties, antibacterial effects, and the ability regulate wound microenvironment.

Language: Английский

Citations

0
Multifunctional Polyoxovanadate-Based Covalent Organic Polymer for Bacteria-Infected Wound Therapy DOI
Yinuo Li, Liyan Zhao,

Manli Liu

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

The special pathological microenvironment of infected wounds (pathology weakly acidic, hypoxic, and overexpressed H2O2) provides fertile soil for the development disease. Tailoring treatment based on specific characteristics infectious (IME) has emerged as a novel direction in antimicrobial therapies. Here, polyoxovanadate (POV)-based covalent organic polymer (POV-Fc-COP) with inherent photothermal activity was facilely prepared via copolymerization 1,1′-bi(3-dimethylamino-1-oxo-2-enyl-ferrocene) (BDOEF) tris-NH2-modified POV (tris-V6O9), which nanovanadium oxide (V2O3 V2O5) core shell were generated directly during Michael addition–elimination reaction. unique structure composition impart pH-responsive peroxidase-like (POD-like) catalase-like (CAT-like) activities, concurrently, to POV-Fc-COP. Specifically, acid-activated mimicking-POD could consume H2O2 microenvironment, producing toxic •OH combat bacteria biofilms. vanadium consumes excessive acid, resulting an increase pH. Meanwhile, CAT-like transform excess expression into O2 relieve hypoxia induced by damage blood vessels facilitate wound healing. Additionally, synergistic amplified therapeutic effect triggered application laser irradiation facilitates rapid eradication biofilm, minimizing detrimental impacts bacterial proliferation IME, thereby accelerating restoration IME return normal state. Therefore, POV-Fc-COP dual-enzyme functionality not only utilize but also regulate significantly expediting healing bacteria-infected wounds. This study demonstrates simple method preparation intelligent platform programmed antibacterial antibiofilm formation, thus promoting while utilizing improving IME.

Language: Английский

Citations

0
Biomineralization of Bi2S3-Gd2O3 nanocomposites: a novel approach for enhanced photothermal and MRI applications DOI Creative Commons
Qiang Lu,

B. H. Zhang,

Ting‐Hua Yi

et al.

Digest Journal of Nanomaterials and Biostructures, Journal Year: 2024, Volume and Issue: 19(4), P. 1903 - 1920

Published: Dec. 15, 2024

In this study, Bi2S3-Gd2O3 nanocomposites (Bi2S3-Gd2O3@BSA) were prepared via biomineralization using albumin as a template, and the nanomaterials directed to tumor site through surface folic acid modification. Among these materials, Bi2S3 serves an effective photothermal conversion agent (PTA) for therapy at sites, attributed its impressive efficiency. contrast, Gd2O3, being paramagnetic substance, can serve effectively contrast in magnetic resonance imaging (MRI). According vitro vivo experiments, exhibit low toxicity, favorable biocompatibility, outstanding properties. Upon exposure 808 nm laser irradiation, quickly reach therapeutic temperature necessary treatment. With modification, accumulate region, enabling efficient This strategy provides fresh outlook purposeful design of diagnostic agents aimed therapy.

Language: Английский

Citations

0