Management of ROS and Regulatory Cell Death in Myocardial Ischemia–Reperfusion Injury
Molecular Biotechnology,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 9, 2024
Язык: Английский
Research progress of sorafenib drug delivery system in the treatment of hepatocellular carcinoma: An update
Qiang-qiang Fan,
Huan Tian,
Jiangxue Cheng
и другие.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117118 - 117118
Опубликована: Июль 14, 2024
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
prevalent
malignant
tumors
in
contemporary
era,
representing
a
significant
global
health
concern.
Early
HCC
patients
have
mild
symptoms
or
are
asymptomatic,
which
promotes
onset
and
progression
disease.
Moreover,
advanced
insensitive
to
chemotherapy,
making
traditional
clinical
treatment
unable
block
cancer
development.
Sorafenib
(SFB)
first-line
targeted
drug
for
with
anti-angiogenesis
anti-tumor
cell
proliferation
effects.
However,
efficacy
SFB
constrained
by
its
off-target
distribution,
rapid
metabolism,
multi-drug
resistance.
In
recent
years,
nanoparticles
based
on
variety
materials
been
demonstrated
enhance
targeting
therapeutic
against
HCC.
Concurrently,
advent
joint
delivery
systems
has
furnished
crucial
empirical
evidence
reversing
This
review
will
summarize
application
nanotechnology
field
over
past
five
years.
It
focus
research
progress
combined
multiple
modalities
treatment.
Язык: Английский
Chronic NaAsO2 exposure promotes migration and invasion of prostate cancer cells by Akt/GSK-3β/β-catenin/TCF4 axis-mediated epithelial-mesenchymal transition
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
290, С. 117741 - 117741
Опубликована: Янв. 1, 2025
Inorganic
arsenic
is
a
Class
I
human
Carcinogen.
However,
the
role
of
chronic
inorganic
exposure
on
prostate
cancer
metastasis
still
unclear.
This
study
aimed
to
investigate
effects
and
mechanism
NaAsO2
migration
invasion
cells.
DU145
PC-3
cells
were
exposed
(2
μM)
for
25
generations.
Wound
healing
Transwell
assays
showed
that
promoted
In
addition,
induced
epithelial-mesenchymal
transition
(EMT)
by
promoting
β-catenin/TCF4
transcriptional
activity.
Mechanically,
GSK-3β
inactivation
in
"disruption
complex"
through
Akt-
mediated
phosphorylation
at
serine
9,
then
inhibited
ubiquitination
degradation
β-catenin,
which
led
its
nuclear
translocation.
Ly294002,
selective
phosphatidylinositol
3-kinase
(PI3K)/Akt
inhibitor,
suppressed
complex
activation
EMT
blocking
Akt-mediated
Moreover,
Ly294002
alleviated
NaAsO2-induced
These
findings
provide
evidence
promotes
via
an
driven
AKT/GSK-3β/β-catenin/TCF4
signaling
axis.
Akt
expected
be
potential
therapeutic
target
exposure-mediated
metastasis.
Язык: Английский