Chronic NaAsO2 exposure promotes migration and invasion of prostate cancer cells by Akt/GSK-3β/β-catenin/TCF4 axis-mediated epithelial-mesenchymal transition DOI Creative Commons
Zhihui Zhang,

Hai-Xin Yan,

Mingdong Liu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117741 - 117741

Published: Jan. 1, 2025

Inorganic arsenic is a Class I human Carcinogen. However, the role of chronic inorganic exposure on prostate cancer metastasis still unclear. This study aimed to investigate effects and mechanism NaAsO2 migration invasion cells. DU145 PC-3 cells were exposed (2 μM) for 25 generations. Wound healing Transwell assays showed that promoted In addition, induced epithelial-mesenchymal transition (EMT) by promoting β-catenin/TCF4 transcriptional activity. Mechanically, GSK-3β inactivation in "disruption complex" through Akt- mediated phosphorylation at serine 9, then inhibited ubiquitination degradation β-catenin, which led its nuclear translocation. Ly294002, selective phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor, suppressed complex activation EMT blocking Akt-mediated Moreover, Ly294002 alleviated NaAsO2-induced These findings provide evidence promotes via an driven AKT/GSK-3β/β-catenin/TCF4 signaling axis. Akt expected be potential therapeutic target exposure-mediated metastasis.

Language: Английский

Management of ROS and Regulatory Cell Death in Myocardial Ischemia–Reperfusion Injury DOI

Ge Gong,

Wenhui Wan, Xinghu Zhang

et al.

Molecular Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: June 9, 2024

Language: Английский

Citations

10
Research progress of sorafenib drug delivery system in the treatment of hepatocellular carcinoma: An update DOI Open Access

Qiang-qiang Fan,

Huan Tian,

Jiangxue Cheng

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117118 - 117118

Published: July 14, 2024

Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors in contemporary era, representing a significant global health concern. Early HCC patients have mild symptoms or are asymptomatic, which promotes onset and progression disease. Moreover, advanced insensitive to chemotherapy, making traditional clinical treatment unable block cancer development. Sorafenib (SFB) first-line targeted drug for with anti-angiogenesis anti-tumor cell proliferation effects. However, efficacy SFB constrained by its off-target distribution, rapid metabolism, multi-drug resistance. In recent years, nanoparticles based on variety materials been demonstrated enhance targeting therapeutic against HCC. Concurrently, advent joint delivery systems has furnished crucial empirical evidence reversing This review will summarize application nanotechnology field over past five years. It focus research progress combined multiple modalities treatment.

Language: Английский

Citations

6
Chronic NaAsO2 exposure promotes migration and invasion of prostate cancer cells by Akt/GSK-3β/β-catenin/TCF4 axis-mediated epithelial-mesenchymal transition DOI Creative Commons
Zhihui Zhang,

Hai-Xin Yan,

Mingdong Liu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117741 - 117741

Published: Jan. 1, 2025

Inorganic arsenic is a Class I human Carcinogen. However, the role of chronic inorganic exposure on prostate cancer metastasis still unclear. This study aimed to investigate effects and mechanism NaAsO2 migration invasion cells. DU145 PC-3 cells were exposed (2 μM) for 25 generations. Wound healing Transwell assays showed that promoted In addition, induced epithelial-mesenchymal transition (EMT) by promoting β-catenin/TCF4 transcriptional activity. Mechanically, GSK-3β inactivation in "disruption complex" through Akt- mediated phosphorylation at serine 9, then inhibited ubiquitination degradation β-catenin, which led its nuclear translocation. Ly294002, selective phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor, suppressed complex activation EMT blocking Akt-mediated Moreover, Ly294002 alleviated NaAsO2-induced These findings provide evidence promotes via an driven AKT/GSK-3β/β-catenin/TCF4 signaling axis. Akt expected be potential therapeutic target exposure-mediated metastasis.

Language: Английский

Citations

0