The future of bone regeneration: Artificial intelligence in biomaterials discovery
Materials Today Communications,
Год журнала:
2024,
Номер
40, С. 109982 - 109982
Опубликована: Июль 28, 2024
Язык: Английский
Fabrication of a Whitlockite/PLGA Scaffold with Hierarchical Porosity for Bone Repair
Nano Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Regenerating
functional
bone
tissue
in
critical-sized
defects
remains
a
formidable
issue.
Bone-tissue
engineering
(BTE)
scaffolds
are
emerging
as
potential
alternatives
to
transplantation
for
the
repair
of
defects.
However,
developing
BTE
with
unique
bone-healing
properties
and
natural
porous
structure
is
challenging.
Herein,
we
presented
biomimetic
scaffold
hierarchical
porosity
via
solvent
casting/particulate
leaching
method.
The
comprises
osteoinductive
whitlockite
(WH)
nanoparticles
evenly
dispersed
poly(lactic-co-glycolic
acid)
(PLGA)
matrix.
Highly
interconnected
pores
variations
present
scaffold,
enabling
superior
solution
diffusion
compressive
strength.
Notably,
WH/PLGA
effectively
promoted
osteoblast
differentiation
vitro
induced
formation
rat
tibia
defects,
surpassing
performance
both
hydroxyapatite
(HAP)/PLGA
PLGA
scaffold.
This
study
provides
low-cost,
facile,
scalable
strategy
fabricating
favorable
mechanical
properties,
biocompatibility,
capability.
Язык: Английский
Leveraging Large Language Models for Accelerated Learning and Innovation in Biogenic Tissue-Engineered Vascular Grafts
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106935 - 106935
Опубликована: Апрель 1, 2025
Язык: Английский
Bone Response to Biodegradable Metals and In Vitro Evaluation of the Cytocompatibility
JOM,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 17, 2025
Язык: Английский
Ionic substitution through bredigite doping for microstructure and performance adjustment in DLP 3D-printed TPMS porous HA bone scaffolds
Virtual and Physical Prototyping,
Год журнала:
2024,
Номер
19(1)
Опубликована: Ноя. 18, 2024
Hydroxyapatite
(HA)
is
widely
used
in
bone
scaffold
development,
but
still
faces
problems
of
forming
difficulty,
slow
degradation,
and
limited
biological
performance.
In
this
study,
triply
periodic
minimal
surface
(TPMS)
porous
HA
scaffolds
were
prepared
using
desktop-level
DLP
then
doped
with
bredigite
(BR)
to
enhance
their
performance
through
ion
substitution
adjust
microstructure.
The
DLP-prepared
displayed
intricate
curved
structure,
micro-porosity
decreased
while
grain
size
increased
sintering
holding
time.
During
sintering,
Mg2+
from
BR
substituted
Ca2+
HA,
new
secondary
phases,
which
slightly
significantly
micro-porosity.
These
factors
reduced
mechanical
properties
enhanced
degradation.
rapid
release
inorganic
active
ions
phases
the
biomineralization
cell
response.
This
study
demonstrated
potential
construct
complex
ceramic
modulate
microstructure
Язык: Английский