Ionic substitution through bredigite doping for microstructure and performance adjustment in DLP 3D-printed TPMS porous HA bone scaffolds DOI Creative Commons
Wang Guo, Ping Li,

Yuezhen Wei

et al.

Virtual and Physical Prototyping, Journal Year: 2024, Volume and Issue: 19(1)

Published: Nov. 18, 2024

Hydroxyapatite (HA) is widely used in bone scaffold development, but still faces problems of forming difficulty, slow degradation, and limited biological performance. In this study, triply periodic minimal surface (TPMS) porous HA scaffolds were prepared using desktop-level DLP then doped with bredigite (BR) to enhance their performance through ion substitution adjust microstructure. The DLP-prepared displayed intricate curved structure, micro-porosity decreased while grain size increased sintering holding time. During sintering, Mg2+ from BR substituted Ca2+ HA, new secondary phases, which slightly significantly micro-porosity. These factors reduced mechanical properties enhanced degradation. rapid release inorganic active ions phases the biomineralization cell response. This study demonstrated potential construct complex ceramic modulate microstructure

Language: Английский

The future of bone regeneration: Artificial intelligence in biomaterials discovery DOI

Jinfei Fan,

Jiazhen Xu,

Xiaobo Wen

et al.

Materials Today Communications, Journal Year: 2024, Volume and Issue: 40, P. 109982 - 109982

Published: July 28, 2024

Language: Английский

Citations

4
Fabrication of a Whitlockite/PLGA Scaffold with Hierarchical Porosity for Bone Repair DOI
Cai‐Feng Wang, Ruofei Zhang, Ki‐Jae Jeong

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Regenerating functional bone tissue in critical-sized defects remains a formidable issue. Bone-tissue engineering (BTE) scaffolds are emerging as potential alternatives to transplantation for the repair of defects. However, developing BTE with unique bone-healing properties and natural porous structure is challenging. Herein, we presented biomimetic scaffold hierarchical porosity via solvent casting/particulate leaching method. The comprises osteoinductive whitlockite (WH) nanoparticles evenly dispersed poly(lactic-co-glycolic acid) (PLGA) matrix. Highly interconnected pores variations present scaffold, enabling superior solution diffusion compressive strength. Notably, WH/PLGA effectively promoted osteoblast differentiation vitro induced formation rat tibia defects, surpassing performance both hydroxyapatite (HAP)/PLGA PLGA scaffold. This study provides low-cost, facile, scalable strategy fabricating favorable mechanical properties, biocompatibility, capability.

Language: Английский

Citations

0
Leveraging Large Language Models for Accelerated Learning and Innovation in Biogenic Tissue-Engineered Vascular Grafts DOI
Fernando Gomes de Souza,

Karine Velasco,

S. D. C. CUNHA

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106935 - 106935

Published: April 1, 2025

Language: Английский

Citations

0
Bone Response to Biodegradable Metals and In Vitro Evaluation of the Cytocompatibility DOI Creative Commons
Edgar B. Montúfar

JOM, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
Ionic substitution through bredigite doping for microstructure and performance adjustment in DLP 3D-printed TPMS porous HA bone scaffolds DOI Creative Commons
Wang Guo, Ping Li,

Yuezhen Wei

et al.

Virtual and Physical Prototyping, Journal Year: 2024, Volume and Issue: 19(1)

Published: Nov. 18, 2024

Hydroxyapatite (HA) is widely used in bone scaffold development, but still faces problems of forming difficulty, slow degradation, and limited biological performance. In this study, triply periodic minimal surface (TPMS) porous HA scaffolds were prepared using desktop-level DLP then doped with bredigite (BR) to enhance their performance through ion substitution adjust microstructure. The DLP-prepared displayed intricate curved structure, micro-porosity decreased while grain size increased sintering holding time. During sintering, Mg2+ from BR substituted Ca2+ HA, new secondary phases, which slightly significantly micro-porosity. These factors reduced mechanical properties enhanced degradation. rapid release inorganic active ions phases the biomineralization cell response. This study demonstrated potential construct complex ceramic modulate microstructure

Language: Английский

Citations

1