Targeting to miR-130b-5p/TLR4: How sodium danshensu suppresses inflammatory response of microglia in cerebral ischemia-reperfusion injury

International Immunopharmacology, Год журнала: 2025, Номер 153, С. 114497 - 114497

Опубликована: Март 22, 2025

Язык: Английский

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The diagnostic value of a breast cancer diagnosis model based on serum MiRNAs and serum tumor markers

World Journal of Surgical Oncology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 29, 2025

Abstract Background Breast cancer (BCa) is the leading cause of cancer-related death among women worldwide. MicroRNAs (miRNAs) are promising tools for diagnosis and prognosis. This study investigated role serum miRNAs tumor markers (TMs) in BCa. Methods Differentially expressed were screened from samples BCa patients healthy individuals via high-throughput sequencing. The expression hsa-miR-1911-3p, hsa-miR-4694-5p, hsa-miR-548ao-5p, hsa-miR-4804-3p 169 116 controls was detected qRT-PCR. Serum tumor-associated antigens by chemiluminescence. Logistic regression subsequently used to develop miRNA panel I, TM II, (miRNA + TM) III models. Receiver operating characteristic (ROC) curve, precision-recall (PR) curve decision analyses (DCA) performed assess accuracy three models diagnosis. Additionally, relationships between clinical characteristics with assessed. Results Four (hsa-miR-1911-3p, hsa-miR-4804-3p) newly associated I based on hsa-miR-548ao-5p showed greater diagnostic effectiveness than II antigen 125 (CA125) 153 (CA153), AUC values 0.816 0.777, respectively. had higher an value 0.870. miR-548ao-5p miR-4804-3p closely related features, such as human epidermal growth factor receptor 2 (HER2), estrogen (ER), progesterone (PR), HER2-enriched subtype, stage III/IV, lymph node-transplanted breast cancer. Conclusion MiR-548ao-5p miR-4804-3 could serve potential biomarkers

Язык: Английский

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Extracellular Vesicle-Derived miRNAs in Ischemic Stroke: Roles in Neuroprotection, Tissue Regeneration, and Biomarker Potential

Cellular and Molecular Neurobiology, Год журнала: 2025, Номер 45(1)

Опубликована: Март 31, 2025

Язык: Английский

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Glial and blood-brain barrier cell-derived exosomes: Implications in stroke

Microvascular Research, Год журнала: 2025, Номер unknown, С. 104812 - 104812

Опубликована: Апрель 1, 2025

Язык: Английский

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