Skin‐Inspired and Self‐Regulated Hydrophobic Hydrogel for Diabetic Wound Therapy
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Diabetic
wounds
are
refractory
and
recurrent
diseases
that
necessitate
the
development
of
multifunctional
dressings.
Inspired
by
structure
function
skin,
we
herein
delicately
design
a
novel
swollen
hydrophobic
hydrogel
(QL@MAB)
composed
methyl
acrylate
(MA)
(3-acrylamidophenyl)boronic
acid
(AAPBA)
network
co-loaded
with
antioxidant
quercetin
(Q)
antibiotic
levofloxacin
(L)
for
efficient
diabetic
wound
therapy.
The
MA
segments
undergo
phase
separation
to
form
dense
"epidermis",
ensuring
prolonged
drug
diffusion,
long-term
water
retention,
high
content.
Meanwhile,
AAPBA
generate
glucose-labile
"sweat
pores"
via
borate
ester
bonds
polyphenol
Q.
Upon
encountering
hyperglycemic
microenvironment,
dilated
due
cleavage
exposure
diffusion
channel,
facilitating
release
accelerated
healing.
In
infected
rats,
QL@MAB
achieves
rapid
debridement
re-epithelization
while
promoting
angiogenesis,
hair
follicle
regeneration,
extracellular
matrix
remodeling.
Taken
together,
this
study
not
only
represents
multipronged
dressing
effective
interventions
but
also
contributes
rational
smart
hydrogels
tailored
biomedical
applications.
Язык: Английский
Engineered hydrogel platform for diabetic wound healing
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160379 - 160379
Опубликована: Фев. 1, 2025
Язык: Английский
Smart bandage with multi-sensor system for wound healing and microenvironment monitoring
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160509 - 160509
Опубликована: Фев. 1, 2025
Язык: Английский
Protein S-acylation: Pathological mechanisms and novel therapeutic targets for diabetic complications
Ruiting Liu,
Nuo Xu,
Xuejiao Song
и другие.
Chinese Herbal Medicines,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Ultrasound-induced piezoionic hydrogels with antibacterial and antioxidant properties for promoting infected diabetic wound healing
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
new
class
of
ultrasound-induced
piezoionic
hydrogels
with
antibacterial
and
antioxidant
properties
are
developed
to
accelerate
infected
diabetic
wound
healing.
Язык: Английский
A biomimetic nanofiber composite hydrogel with tissue adhesion, self-healing and antibacterial ability for infected wound healing
Acta Biomaterialia,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Advancements and Prospects of pH-Responsive Hydrogels in Biomedicine
Gels,
Год журнала:
2025,
Номер
11(4), С. 293 - 293
Опубликована: Апрель 15, 2025
As
an
intelligent
polymer
material,
pH-sensitive
hydrogels
exhibit
the
capability
to
dynamically
sense
alterations
in
ambient
pH
levels
and
subsequently
initiate
corresponding
physical
or
chemical
responses,
including
swelling,
contraction,
degradation,
ion
exchange.
Given
significant
variations
inherent
human
pathophysiological
microenvironments,
particularly
tumor
tissues,
inflammatory
lesions,
gastrointestinal
system,
these
smart
materials
demonstrate
remarkable
application
potential
across
diverse
domains
such
as
targeted
drug
delivery
systems,
regenerative
medicine
engineering,
biosensing,
disease
diagnostics.
Recent
breakthroughs
nanotechnology
precision
have
substantially
propelled
advancements
design
of
pH-responsive
hydrogels.
This
review
systematically
elaborates
on
current
research
progress
future
challenges
regarding
biomedical
applications,
with
particular
emphasis
their
stimulus–response
mechanisms,
fabrication
methodologies,
multifunctional
integration
strategies,
scenarios.
Язык: Английский