Advancements and Prospects of pH-Responsive Hydrogels in Biomedicine DOI Creative Commons

Ke Gao,

Ke Xu

Gels, Год журнала: 2025, Номер 11(4), С. 293 - 293

Опубликована: Апрель 15, 2025

As an intelligent polymer material, pH-sensitive hydrogels exhibit the capability to dynamically sense alterations in ambient pH levels and subsequently initiate corresponding physical or chemical responses, including swelling, contraction, degradation, ion exchange. Given significant variations inherent human pathophysiological microenvironments, particularly tumor tissues, inflammatory lesions, gastrointestinal system, these smart materials demonstrate remarkable application potential across diverse domains such as targeted drug delivery systems, regenerative medicine engineering, biosensing, disease diagnostics. Recent breakthroughs nanotechnology precision have substantially propelled advancements design of pH-responsive hydrogels. This review systematically elaborates on current research progress future challenges regarding biomedical applications, with particular emphasis their stimulus–response mechanisms, fabrication methodologies, multifunctional integration strategies, scenarios.

Язык: Английский

Skin‐Inspired and Self‐Regulated Hydrophobic Hydrogel for Diabetic Wound Therapy DOI
Yonghang Liu, Xiaoxue Yang, Kefan Wu

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Diabetic wounds are refractory and recurrent diseases that necessitate the development of multifunctional dressings. Inspired by structure function skin, we herein delicately design a novel swollen hydrophobic hydrogel (QL@MAB) composed methyl acrylate (MA) (3-acrylamidophenyl)boronic acid (AAPBA) network co-loaded with antioxidant quercetin (Q) antibiotic levofloxacin (L) for efficient diabetic wound therapy. The MA segments undergo phase separation to form dense "epidermis", ensuring prolonged drug diffusion, long-term water retention, high content. Meanwhile, AAPBA generate glucose-labile "sweat pores" via borate ester bonds polyphenol Q. Upon encountering hyperglycemic microenvironment, dilated due cleavage exposure diffusion channel, facilitating release accelerated healing. In infected rats, QL@MAB achieves rapid debridement re-epithelization while promoting angiogenesis, hair follicle regeneration, extracellular matrix remodeling. Taken together, this study not only represents multipronged dressing effective interventions but also contributes rational smart hydrogels tailored biomedical applications.

Язык: Английский

Процитировано

1

Engineered hydrogel platform for diabetic wound healing DOI
Jie Cui, Jianbin Shi, Yanjun Liu

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160379 - 160379

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

Smart bandage with multi-sensor system for wound healing and microenvironment monitoring DOI
Leilei Ji, Yuqin Xiao,

Kaige Xu

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160509 - 160509

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

Protein S-acylation: Pathological mechanisms and novel therapeutic targets for diabetic complications DOI Open Access

Ruiting Liu,

Nuo Xu,

Xuejiao Song

и другие.

Chinese Herbal Medicines, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

Ultrasound-induced piezoionic hydrogels with antibacterial and antioxidant properties for promoting infected diabetic wound healing DOI

Chunhua Huang,

Xingxing Shi,

Binying Peng

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A new class of ultrasound-induced piezoionic hydrogels with antibacterial and antioxidant properties are developed to accelerate infected diabetic wound healing.

Язык: Английский

Процитировано

0

A biomimetic nanofiber composite hydrogel with tissue adhesion, self-healing and antibacterial ability for infected wound healing DOI
Yan Tian, Xiaogang Bao, Shunmin Wang

и другие.

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Advancements and Prospects of pH-Responsive Hydrogels in Biomedicine DOI Creative Commons

Ke Gao,

Ke Xu

Gels, Год журнала: 2025, Номер 11(4), С. 293 - 293

Опубликована: Апрель 15, 2025

As an intelligent polymer material, pH-sensitive hydrogels exhibit the capability to dynamically sense alterations in ambient pH levels and subsequently initiate corresponding physical or chemical responses, including swelling, contraction, degradation, ion exchange. Given significant variations inherent human pathophysiological microenvironments, particularly tumor tissues, inflammatory lesions, gastrointestinal system, these smart materials demonstrate remarkable application potential across diverse domains such as targeted drug delivery systems, regenerative medicine engineering, biosensing, disease diagnostics. Recent breakthroughs nanotechnology precision have substantially propelled advancements design of pH-responsive hydrogels. This review systematically elaborates on current research progress future challenges regarding biomedical applications, with particular emphasis their stimulus–response mechanisms, fabrication methodologies, multifunctional integration strategies, scenarios.

Язык: Английский

Процитировано

0