Addictive Behaviors, Год журнала: 2024, Номер 155, С. 108027 - 108027
Опубликована: Апрель 5, 2024
Язык: Английский
Brain Sciences, Год журнала: 2024, Номер 14(6), С. 610 - 610
Опубликована: Июнь 18, 2024
Alcohol misuse is associated with altered punishment and reward processing. Here, we investigated neural network responses to the molecular profiles of connectivity features predicting alcohol use severity in young adults. We curated Human Connectome Project data employed connectome-based predictive modeling (CPM) examine how functional (FC) during wins losses are severity, quantified by Semi-Structured Assessment for Genetics Alcoholism, 981 combined CPM findings JuSpace toolbox characterize severity. The connectomics appeared specific, comprising less than 0.12% all features, including medial frontal, motor/sensory, cerebellum/brainstem networks processing fronto-parietal, motor/sensory Spatial correlation analyses showed that these were predominantly serotonergic GABAa signaling. To conclude, a distinct pattern predicted adult drinkers. These “neural fingerprints” elucidate impacts brain provide evidence new targets future intervention.
Язык: Английский
Процитировано
3
Brain Research, Год журнала: 2024, Номер 1838, С. 148947 - 148947
Опубликована: Апрель 23, 2024
Язык: Английский
Процитировано
2
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Фев. 7, 2024
ABSTRACT Background Alcohol misuse is associated with altered punishment and reward processing. Here, we investigated neural network responses to the molecular profiles of connectivity features predicting alcohol use severity in young adults. Methods We curated Human Connectome Project data employed connectome-based predictive modeling (CPM) examine how functional (FC) during wins losses 981 was quantified by first principal component analysis all drinking measures Semi-Structured Assessment for Genetics Alcoholism. combined CPM findings JuSpace toolbox characterize severity. Results The connectomics appeared specific, comprising less than 0.12% features. These connectivities featured medial frontal, motor/sensory, cerebellum/brainstem networks processing fronto-parietal, motor/sensory Spatial correlation analyses showed that these were predominantly serotonergic GABAa signaling. Conclusions A distinct pattern predicted adult drinkers. “neural fingerprints” help elucidating impact on brain providing evidence new targets future intervention.
Язык: Английский
Процитировано
0
Psychiatry Research Neuroimaging, Год журнала: 2024, Номер 340, С. 111809 - 111809
Опубликована: Март 24, 2024
Alcohol use disorder is associated with overvaluation of alcohol relative to other rewards, in part due dynamic increases value response alcohol-related cues. In a neuroeconomic framework, cues increase behavioral economic demand for alcohol, but the neural correlates these cue effects are unknown. This functional magnetic resonance imaging study combined purchase task an exposure 72 heavy drinkers established sensitivity (51 % female; mean age=33.74). Participants reported how many drinks they would consume from $0-$80/drink following neutral and images fixed order. purchased significantly more compared condition, which was also evident indices (i.e., intensity, breakpoint, Omax, elasticity; ps<0.001; ds=0.46–0.92). decisions were activation rostral middle medial frontal gyri, anterior insula, posterior parietal cortex, dorsal striatum, among regions. Activation lower across regions potentially greater automaticity choices presence or attenuation responses These results contribute growing literature using neuroeconomics understand misuse provide foundation future research investigating decision-making environmental triggers.
Язык: Английский
Процитировано
0
Addictive Behaviors, Год журнала: 2024, Номер 155, С. 108027 - 108027
Опубликована: Апрель 5, 2024
Язык: Английский
Процитировано
0