Expert Review of Vaccines,
Год журнала:
2021,
Номер
20(12), С. 1549 - 1560
Опубликована: Сен. 28, 2021
Introduction:
Coronavirus
outbreak
2019
(COVID-19)
has
affected
all
the
corners
of
globe
and
created
chaos
to
human
life.
In
order
put
some
control
on
pandemic,
vaccines
are
urgently
required
that
safe,
cost
effective,
easy
produce,
most
importantly
induce
appropriate
immune
responses
protection
against
viral
infection.
DNA
possess
these
features
promising
candidates
for
providing
SARS-CoV-2.Area
covered:
Current
understanding
advances
in
toward
COVID-19,
especially
those
under
various
stages
clinical
trials.Expert
opinion:
Through
vaccines,
host
cells
momentarily
transformed
into
factories
produce
proteins
SARS-CoV-2.
The
system
detects
develop
antibodies
neutralize
prevent
This
vaccine
platform
additional
benefits
compared
traditional
vaccination
strategies
like
strong
cellular
response,
higher
safety
margin,
a
simple
production
process
as
per
cGMP
norms,
lack
any
infectious
agent,
robust
large-scale
production.
Nature Reviews Drug Discovery,
Год журнала:
2023,
Номер
22(5), С. 387 - 409
Опубликована: Март 27, 2023
Poor
medication
adherence
is
a
pervasive
issue
with
considerable
health
and
socioeconomic
consequences.
Although
the
underlying
reasons
are
generally
understood,
traditional
intervention
strategies
rooted
in
patient-centric
education
empowerment
have
proved
to
be
prohibitively
complex
and/or
ineffective.
Formulating
pharmaceutical
drug
delivery
system
(DDS)
promising
alternative
that
can
directly
mitigate
many
common
impediments
adherence,
including
frequent
dosing,
adverse
effects
delayed
onset
of
action.
Existing
DDSs
already
positively
influenced
patient
acceptability
improved
rates
across
various
disease
types.
The
next
generation
systems
potential
instate
an
even
more
radical
paradigm
shift
by,
for
example,
permitting
oral
biomacromolecules,
allowing
autonomous
dose
regulation
enabling
several
doses
mimicked
single
administration.
Their
success,
however,
contingent
on
their
ability
address
problems
made
unsuccessful
past.
Improving
recognized
as
one
most
impactful
cost-effective
improving
general
population.
Here,
Baryakova
colleagues
assess
next-generation
discuss
impact
had
different
Nano Letters,
Год журнала:
2019,
Номер
19(3), С. 1914 - 1921
Опубликована: Фев. 6, 2019
Vaccination
represents
one
of
the
most
effective
means
preventing
infectious
disease.
In
order
to
maximize
utility
vaccines,
highly
potent
formulations
that
are
easy
administer
and
promote
high
patient
compliance
desired.
present
work,
a
biomimetic
self-propelling
micromotor
formulation
is
developed
for
use
as
an
oral
antivirulence
vaccine.
The
propulsion
provided
by
magnesium-based
core,
cell
membrane
coating
used
detain
neutralize
toxic
antigenic
payload.
resulting
motor
toxoids
leverage
their
properties
in
more
effectively
elicit
mucosal
immune
responses.
After
demonstrating
successful
fabrication
toxoids,
uptake
shown
vitro.
When
delivered
mice
via
route,
it
then
confirmed
greatly
improves
retention
material
small
intestine
vivo.
Ultimately,
this
translates
into
markedly
elevated
generation
antibody
titers
against
model
toxin.
This
work
provides
proof-of-concept
highlighting
benefits
active
delivery
vaccine
development,
opening
door
new
set
applications,
which
technology
can
provide
significant
benefits.
Advanced Materials,
Год журнала:
2019,
Номер
32(13)
Опубликована: Июнь 28, 2019
Abstract
Breakthroughs
in
materials
engineering
have
accelerated
the
progress
of
immunotherapy
preclinical
studies.
The
interplay
chemistry
and
has
resulted
improved
loading,
targeting,
release
immunomodulatory
agents.
An
overview
that
are
used
to
enable
or
improve
success
immunotherapies
studies
is
presented,
from
immunosuppressive
proinflammatory
strategies,
with
particular
emphasis
on
technologies
poised
for
clinical
translation.
organized
based
their
characteristic
length
scale,
whereby
enabling
feature
each
technology
by
structure
material.
For
example,
mechanisms
which
i)
nanoscale
can
targeting
infiltration
payloads
into
tissues
cells,
ii)
microscale
facilitate
cell‐mediated
transport
serve
as
artificial
antigen‐presenting
iii)
macroscale
form
basis
microenvironments
promote
cell
reprogramming
discussed.
As
a
step
toward
establishing
set
design
rules
future
immunotherapies,
intrinsically
activate
suppress
immune
system
reviewed.
Finally,
brief
outlook
trajectory
these
systems
how
they
may
be
address
unsolved
challenges
cancer,
infectious
diseases,
autoimmunity
presented.
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 484 - 484
Опубликована: Фев. 1, 2023
The
oral
route
is
the
most
preferred
for
systemic
and
local
drug
delivery.
However,
delivery
system
faces
harsh
physiological
physicochemical
environment
of
gastrointestinal
tract,
which
limits
bioavailability
targeted
design
system.
Innovative
pharmaceutical
approaches
including
nanoparticulate
formulations,
biomimetic
microfabricated
devices
have
been
explored
to
optimize
targeting
bioavailability.
In
this
review,
anatomical
factors,
biochemical
physiology
factors
that
influence
delivering
via
are
discussed
recent
advance
in
conventional
novel
improving
ability
highlighted.
We
also
address
challenges
opportunities
systems
future.
Biomolecules,
Год журнала:
2021,
Номер
11(8), С. 1072 - 1072
Опубликована: Июль 21, 2021
To
date,
vaccination
has
become
one
of
the
most
effective
strategies
to
control
and
reduce
infectious
diseases,
preventing
millions
deaths
worldwide.
The
earliest
vaccines
were
developed
as
live-attenuated
or
inactivated
pathogens,
and,
although
they
still
represent
extended
human
vaccine
types,
also
face
some
issues,
such
potential
revert
a
pathogenic
form
formulations
weaker
immune
response
associated
with
vaccines.
Advances
in
genetic
engineering
have
enabled
improvements
design
strategies,
recombinant
subunit
vaccines,
emerged,
expanding
number
diseases
that
can
be
prevented.
Moreover,
antigen
display
systems
VLPs
those
designed
by
nanotechnology
improved
efficacy
Platforms
for
production
evolved
from
first
hosts,
