Plants,
Год журнала:
2021,
Номер
10(6), С. 1238 - 1238
Опубликована: Июнь 18, 2021
Plants
constitute
a
rich
source
of
diverse
classes
valuable
phytochemicals
(e.g.,
phenolic
acids,
flavonoids,
carotenoids,
alkaloids)
with
proven
biological
activity
antioxidant,
anti-inflammatory,
antimicrobial,
etc.).
However,
factors
such
as
low
stability,
poor
solubility
and
bioavailability
limit
their
food,
cosmetics
pharmaceutical
applications.
In
this
regard,
wide
range
delivery
systems
have
been
developed
to
increase
the
stability
plant-derived
bioactive
compounds
upon
processing,
storage
or
under
gastrointestinal
digestion
conditions,
enhance
solubility,
mask
undesirable
flavors
well
efficiently
deliver
them
target
tissues
where
they
can
exert
promote
human
health.
present
review,
latest
advances
regarding
design
innovative
for
pure
plant
compounds,
extracts
essential
oils,
in
order
overcome
above-mentioned
challenges,
are
presented.
Moreover,
broad
spectrum
applications
along
future
trends
critically
discussed.
Journal of Nanobiotechnology,
Год журнала:
2021,
Номер
19(1)
Опубликована: Фев. 25, 2021
Abstract
Virus-like
particles
(VLPs)
are
virus-derived
structures
made
up
of
one
or
more
different
molecules
with
the
ability
to
self-assemble,
mimicking
form
and
size
a
virus
particle
but
lacking
genetic
material
so
they
not
capable
infecting
host
cell.
Expression
self-assembly
viral
structural
proteins
can
take
place
in
various
living
cell-free
expression
systems
after
which
be
assembled
reconstructed.
VLPs
gaining
popularity
field
preventive
medicine
date,
wide
range
VLP-based
candidate
vaccines
have
been
developed
for
immunization
against
infectious
agents,
latest
is
vaccine
SARS-CoV-2,
efficacy
being
evaluated.
highly
immunogenic
able
elicit
both
antibody-
cell-mediated
immune
responses
by
pathways
from
those
elicited
conventional
inactivated
vaccines.
However,
there
still
many
challenges
this
surface
display
system
that
need
addressed
future.
classified
as
subunit
subdivided
into
enveloped
non-
subtypes
discussed
review
article.
also
recently
received
attention
their
successful
applications
targeted
drug
delivery
use
gene
therapy.
The
development
effective
forms
VLP
modification
such
way
introduced
specific
cells
tissues
increase
half-life
likely
expand
Recent
advances
production
fabrication
including
exploration
types
development,
well
prevention
diseases
cancers
resulting
interaction
with,
mechanism
activation
of,
humoral
cellular
review.
Signal Transduction and Targeted Therapy,
Год журнала:
2021,
Номер
6(1)
Опубликована: Июнь 7, 2021
Abstract
Over
the
past
decades,
great
interest
has
been
given
to
biomimetic
nanoparticles
(BNPs)
since
rise
of
targeted
drug
delivery
systems
and
nanotechnology.
Biological
vectors
including
cell
membranes,
extracellular
vesicles
(EVs),
viruses
are
considered
promising
candidates
for
owing
their
biocompatibility
biodegradability.
BNPs,
integration
biological
functional
agents,
anticipated
load
cargos
or
camouflage
synthetic
achieve
delivery.
Despite
excellent
intrinsic
properties,
natural
deliberately
modified
endow
multiple
functions
such
as
good
permeability,
improved
loading
capability,
high
specificity.
Through
structural
modification
transformation
vectors,
they
pervasively
utilized
more
effective
vehicles
that
can
deliver
contrast
chemotherapy
drugs,
nucleic
acids,
genes
target
sites
refractory
disease
therapy.
This
review
summarizes
recent
advances
in
based
on
EVs,
viruses,
highlighting
potential
applications
BNPs
fields
biomedical
imaging
therapy
industry,
well
discussing
possibility
clinical
translation
exploitation
trend
these
BNPs.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(5), С. 3355 - 3423
Опубликована: Янв. 1, 2021
Nanomaterials
offer
unique
physical,
chemical
and
biological
properties
of
interest
for
medical
imaging
therapy.
Over
the
last
two
decades,
there
has
been
an
increasing
effort
to
translate
nanomaterial-based
medicinal
products
(so-called
nanomedicines)
into
clinical
practice
and,
although
multiple
nanoparticle-based
formulations
are
clinically
available,
is
still
a
disparity
between
number
pre-clinical
those
that
reach
approval.
To
facilitate
efficient
translation
nanomedicinal-drugs,
it
important
study
their
whole-body
biodistribution
pharmacokinetics
from
early
stages
development.
Integrating
this
knowledge
with
therapeutic
profile
and/or
toxicity
should
provide
powerful
combination
efficiently
inform
nanomedicine
trials
allow
selection
most
promising
candidates.
In
context,
radiolabelling
nanomaterials
allows
non-invasive
in
vivo
tracking
by
sensitive
techniques
positron
emission
tomography
(PET),
single
photon
computed
(SPECT).
Furthermore,
certain
radionuclides
specific
nuclear
emissions
can
elicit
effects
themselves,
leading
radionuclide-based
ensure
robust
information
during
development
PET/SPECT
radionuclide
therapy,
appropriate
method
its
limitations
critical.
Different
strategies
available
depending
on
type
material,
final
application.
review
we
describe
different
currently
critical
vision
over
advantages
disadvantages.
The
aim
relevant
up-to-date
field,
support
future
nanomedicinal
Frontiers in Chemistry,
Год журнала:
2021,
Номер
9
Опубликована: Апрель 16, 2021
In
the
recent
times,
nanomaterials
have
emerged
in
field
of
biology,
medicine,
electronics,
and
agriculture
due
to
their
immense
applications.
Owing
nanoscale
sizes,
they
present
large
surface/volume
ratio,
characteristic
structures,
similar
dimensions
biomolecules
resulting
unique
properties
for
biomedical
The
chemical
physical
methods
synthesize
nanoparticles
own
limitations
which
can
be
overcome
using
biological
synthesis.
Moreover,
through
biogenic
synthesis
route,
usage
microorganisms
has
offered
a
reliable,
sustainable,
safe,
environmental
friendly
technique
nanosynthesis.
Bacterial,
algal,
fungal,
yeast
cells
are
known
transport
metals
from
environment
convert
them
elemental
nanoparticle
forms
either
accumulated
or
secreted.
Additionally,
robust
nanocarriers
also
been
developed
viruses.
order
prevent
aggregation
promote
stabilization
nanoparticles,
capping
agents
often
secreted
during
biosynthesis.
Microbial
find
applications
rapid
diagnostics,
imaging,
biopharmaceuticals,
drug
delivery
systems,
antimicrobials,
biomaterials
tissue
regeneration
as
well
biosensors.
major
challenges
therapeutic
microbial
include
biocompatibility,
bioavailability,
stability,
degradation
gastro-intestinal
tract,
immune
response.
Thus,
current
review
article
is
focused
on
microbe-mediated
various
different
strains
explored
such
along
with
future
Journal of Controlled Release,
Год журнала:
2022,
Номер
342, С. 345 - 361
Опубликована: Янв. 10, 2022
The
discovery
of
clustered
regularly
interspaced
short
palindromic
repeats
(CRISPR)
genome
editing
technology
opened
the
door
to
provide
a
versatile
approach
for
treating
multiple
diseases.
Promising
results
have
been
shown
in
numerous
pre-clinical
studies
and
clinical
trials.
However,
safe
effective
method
deliver
genome-editing
components
is
still
key
challenge
vivo
therapy.
Adeno-associated
virus
(AAV)
one
most
commonly
used
vector
systems
date,
but
immunogenicity
against
capsid,
liver
toxicity
at
high
dose,
potential
genotoxicity
caused
by
off-target
mutagenesis
genomic
integration
remain
unsolved.
Recently
developed
transient
delivery
systems,
such
as
virus-like
particle
(VLP)
lipid
nanoparticle
(LNP),
may
solve
some
issues.
This
review
summarizes
existing
possible
solutions
overcome
their
limitations.
Also,
we
highlight
ongoing
trials
therapy
recently
tools
applications.
Frontiers in Microbiology,
Год журнала:
2022,
Номер
12
Опубликована: Янв. 3, 2022
Virus-like
particles
(VLPs)
are
nanostructures
that
possess
diverse
applications
in
therapeutics,
immunization,
and
diagnostics.
With
the
recent
advancements
biomedical
engineering
technologies,
commercially
available
VLP-based
vaccines
being
extensively
used
to
combat
infectious
diseases,
whereas
many
more
different
stages
of
development
clinical
studies.
Because
their
desired
characteristics
terms
efficacy,
safety,
diversity,
approaches
might
become
recurrent
years
come.
However,
some
production
fabrication
challenges
must
be
addressed
before
can
widely
therapeutics.
This
review
offers
insight
into
development,
with
an
emphasis
on
characteristics,
expression
systems,
potential
applicability
as
ideal
candidates
emerging
virulent
pathogens.
Finally,
vaccine
viable
efficient
immunizing
agents
induce
immunity
against
agents,
including,
SARS-CoV-2
protein
nanoparticle-based
has
been
elaborated.
Thus,
VLP
may
serve
effective
alternative
conventional
strategies
combating
diseases.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Фев. 21, 2024
Abstract
Inflammation-associated
diseases
encompass
a
range
of
infectious
and
non-infectious
inflammatory
diseases,
which
continuously
pose
one
the
most
serious
threats
to
human
health,
attributed
factors
such
as
emergence
new
pathogens,
increasing
drug
resistance,
changes
in
living
environments
lifestyles,
aging
population.
Despite
rapid
advancements
mechanistic
research
development
for
these
current
treatments
often
have
limited
efficacy
notable
side
effects,
necessitating
more
effective
targeted
anti-inflammatory
therapies.
In
recent
years,
nanotechnology
has
provided
crucial
technological
support
prevention,
treatment,
detection
inflammation-associated
diseases.
Various
types
nanoparticles
(NPs)
play
significant
roles,
serving
vaccine
vehicles
enhance
immunogenicity
carriers
improve
targeting
bioavailability.
NPs
can
also
directly
combat
pathogens
inflammation.
addition,
facilitated
biosensors
pathogen
imaging
techniques
This
review
categorizes
characterizes
different
NPs,
summarizes
their
applications
It
discusses
challenges
associated
with
clinical
translation
this
field
explores
latest
developments
prospects.
conclusion,
opens
up
possibilities
comprehensive
management
