Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Chemical Society Reviews, Год журнала: 2022, Номер 51(12), С. 4996 - 5041

Опубликована: Янв. 1, 2022

This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.

Язык: Английский

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Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

ACS Nano, Год журнала: 2023, Номер 17(21), С. 20825 - 20849

Опубликована: Ноя. 3, 2023

Understanding the in vivo transport of nanoparticles provides guidelines for designing nanomedicines with higher efficacy and fewer side effects. Among many factors, size plays a key role controlling their behaviors due to existence various physiological thresholds within body size-dependent nano-bio interactions. Encouraged by evolving discoveries nanoparticle-size-dependent biological effects, we believe that it is necessary systematically summarize size-scaling laws nanoparticle vivo. In this review, summarized effect on along journey body: begin administration via different delivery routes, followed targeting intended tissues including tumors other organs, eventually clearance through liver or kidneys. We outlined tools investigating as well. Finally, discussed how may leverage tackle some challenges nanomedicine translation also raised important size-related questions remain be answered future.

Язык: Английский

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New opportunities and old challenges in the clinical translation of nanotheranostics

Nature Reviews Materials, Год журнала: 2023, Номер 8(12), С. 783 - 798

Опубликована: Июль 26, 2023

Язык: Английский

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Biodistribution, pharmacokinetics and excretion studies of intravenously injected nanoparticles and extracellular vesicles: Possibilities and challenges

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 186, С. 114326 - 114326

Опубликована: Май 16, 2022

There is a large interest in developing nanoparticles and extracellular vesicles for delivery of therapeutics or imaging agents. Regulatory approval such products requires knowledge about their biodistribution, metabolism excretion. We here discuss possibilities challenges methods used studies, which most often are performed after labelling with radioactive isotopes fluorescent molecules. It important to evaluate if the labelled unlabeled can be expected behave similarly body. Furthermore, one needs critically consider whether labels still associated product at time analyses. advantages disadvantages different modalities as PET, SPECT, MRI, CT, ultrasound optical whole-body describe how estimate amount harvested organs tissue. Microscopy cells tissues various mass spectrometry also discussed this review.

Язык: Английский

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Functional catalytic nanoparticles (nanozymes) for sensing

Biosensors and Bioelectronics, Год журнала: 2022, Номер 218, С. 114768 - 114768

Опубликована: Окт. 3, 2022

Язык: Английский

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Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection

Chemical Society Reviews, Год журнала: 2022, Номер 51(23), С. 9759 - 9830

Опубликована: Янв. 1, 2022

Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-energy ionizing to kill tumor cells.

Язык: Английский

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Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies

Redox Biology, Год журнала: 2023, Номер 59, С. 102601 - 102601

Опубликована: Янв. 7, 2023

Hydrogen sulfide (H2S) is an important signaling molecule in colorectal cancer (CRC). It produced the colon by catalytic synthesis of colonocytes' enzymatic systems and release intestinal microbes, oxidatively metabolized mitochondria. Both endogenous H2S colonic epithelial cells exogenous lumen contribute to onset progression CRC. The up-regulation synthetases thought be cause elevated levels CRC cells. Different diagnostic probes combination therapies, as well tumor treatment approaches through modulation, have been developed recent years become active area investigation for diagnosis In this review, we focus on specific mechanisms production oxidative metabolism function occurrence, progression, diagnosis, We also discuss present challenges provide insights into future research burgeoning field.

Язык: Английский

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In vivo Biodistribution and Clearance of Magnetic Iron Oxide Nanoparticles for Medical Applications

International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 4067 - 4100

Опубликована: Июль 1, 2023

Abstract: Magnetic iron oxide nanoparticles (magnetite and maghemite) are intensively studied due to their broad potential applications in medical biological sciences. Their unique properties, such as nanometric size, large specific surface area, superparamagnetism, allow them be used targeted drug delivery internal radiotherapy by targeting an external magnetic field. In addition, they successfully resonance imaging (MRI), hyperthermia, radiolabelling. The appropriate design of allows delivered the desired tissues organs. biodistribution nanoparticles, eg, cancerous tumors, is increased using Thus, knowledge these essential for applications. It determining whether captured organs or accumulated other tissues, which may lead toxicity. This review article presents main where accumulate. sites first uptake usually liver, spleen, lymph nodes, but with can also lungs, heart, brain. describes factors affecting including shape, charge, coating molecules, route administration. Modern techniques nanoparticle accumulation concentration isolated body vivo presented. Graphical Keywords: biodistribution, biodegradation

Язык: Английский

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PatchResNet: Multiple Patch Division–Based Deep Feature Fusion Framework for Brain Tumor Classification Using MRI Images

Journal of Digital Imaging, Год журнала: 2023, Номер 36(3), С. 973 - 987

Опубликована: Фев. 16, 2023

Язык: Английский

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Confining Prepared Ultrasmall Nanozymes Loading ATO for Lung Cancer Catalytic Therapy/Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 35(45)

Опубликована: Сен. 25, 2023

Nanozymes with inherent enzyme-mimicking catalytic properties combat malignant tumor progression via therapy, while the therapeutic efficacy still needs to be improved. In this work, ultrasmall platinum nanozymes (nPt) in a confined domain of wormlike pore channel gold nanobipyramidal-mesoporous silica dioxide nanocomposites, producing nanozyme carriers AP-mSi photoenhanced peroxidase ability, are innovatively synthesized. Afterward, based on prepared AP-mSi, lung-cancer probe (AP-HAI) is ingeniously produced by removing SiO2 template, modifying human serum albumin, and loading atovaquone molecules (ATO) as well IR780. Under NIR light irradiation, inner AuP IR780 collaborate for photothermal process, thus facilitating peroxidase-like process H2 O2 . Additionally, loaded ATO, cell respiration inhibitor, can impair metabolism cause oxygen retention, hence enhancing IR780's photodynamic therapy (PDT) effectiveness. As result, PDT nPt nanozymes' ability endow probes high ROS productivity, eliciting antitumor immune responses destroy tissue. Systematic studies reveal that obvious reactive species (ROS) generation obtained strategy using reducing consumption which turn enables synergetic therapy/immunogenic-cell-death-based immunotherapy. The results work would provide theoretical justification practical use probes.

Язык: Английский

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