Pharmaceutics,
Год журнала:
2022,
Номер
14(4), С. 822 - 822
Опубликована: Апрель 8, 2022
Inflammatory
bowel
disease
(IBD)
is
a
chronic
recurrent
intestinal
and
includes
Crohn's
(CD)
ulcerative
colitis
(UC).
Due
to
the
complex
etiology
of
colitis,
current
treatments
IBD
are
quite
limited
mainly
concentrated
on
remission
disease.
In
addition,
side
effects
conventional
drugs
body
cannot
be
ignored.
also
has
certain
relationship
with
colitis-associated
cancer
(CAC),
inflammatory
cells
can
produce
large
number
tumor-promoting
cytokines
promote
tumor
progression.
recent
years,
exosomes
from
plants
have
been
found
ability
load
target
intestine
great
potential
for
treatment
diseases.
This
plant-derived
exosome-targeting
delivery
system
chemical
or
nucleic
acid
deliver
them
sites
stably
efficiently.
review
summarizes
pathophysiological
characteristics
CAC
as
well
application
prospect
plant
in
CAC.
Materials & Design,
Год журнала:
2022,
Номер
221, С. 110894 - 110894
Опубликована: Июль 2, 2022
Although
nano-systems
can
promote
the
cellular
internalization,
polymeric
nanoparticles
(NPs)
are
easily
to
be
destroyed
or
eliminated
in
gastrointestinal
tract,
which
leads
premature
drug
release
insufficient
colonic
accumulation.
A
novel
oral
nano-in-micro
system
for
efficient
delivery
of
curcumin
(Cur)
was
developed
this
study,
hyaluronic
acid
(HA)/zein
complex
NPs
loading
Cur
were
embedded
alginate/chitosan
hydrogel
microparticles
(Cur@NMPs)
with
electrospray
technology.
The
Cur@NMPs
showed
uniform-sized
sphere
an
average
size
218.36
±
10
μm,
encapsulating
Cur@HA/zein
148.64
3.21
nm.
NMPs
sustained
drug-release
profiles
simulated
gastric
fluid,
whereas
it
rapid
fluid.
Mediated
by
HA-CD44
receptor
recognition,
had
increased
uptake
efficiency
macrophages.
Furthermore,
significant
colon-retention
and
bio-adhesiveness
capacity
colon
tissues.
As
expected,
administration
significantly
mitigated
colitis
symptoms
DSS-induced
UC
mice
inhibiting
TLR4/NF-κB
pathway.
above
results
provide
a
useful
strategy
treatment
retaining
advantages
nano-
micro-scaled
carriers.
Abstract
The
therapeutic
outcomes
of
oral
nanomedicines
against
colon
cancer
are
heavily
compromised
by
their
lack
specific
penetration
into
the
internal
tumor,
favorable
anti‐tumor
activity,
and
activation
immunity.
Herein,
hydrogen
peroxide
(H
2
O
)/ultrasound
(US)‐driven
mesoporous
manganese
oxide
(MnO
x
)‐based
nanomotors
constructed
loading
mitochondrial
sonosensitizers
channels
orderly
dual‐functionalizing
surface
with
silk
fibroin
chondroitin
sulfate.
locomotory
activities
tumor‐targeting
capacities
resultant
(CS‐ID@NMs)
greatly
improved
in
presence
H
US
irradiation,
inducing
efficient
mucus‐traversing
deep
tumor
penetration.
excess
microenvironment
(TME)
is
decomposed
hydroxyl
radicals
oxygen
an
Mn
2+
‐mediated
Fenton‐like
reaction,
produced
participates
sonodynamic
therapy
(SDT),
yielding
abundant
singlet
oxygen.
combined
chemodynamic
SDT
cause
effective
ferropotosis
cells
accelerate
release
antigens.
Importantly,
animal
experiments
reveal
that
treatment
combining
hydrogel
(chitosan/alginate)‐embedding
CS‐ID@NMs
immune
checkpoint
inhibitors
can
simultaneously
suppress
growth
primary
distal
tumors
through
direct
killing,
reversion
immunosuppressive
TME,
potentiation
systemic
immunity,
demonstrating
CS‐ID@NM‐based
platform
a
robust
system
for
synergistic
cancer.
Journal of Materials Chemistry B,
Год журнала:
2022,
Номер
10(31), С. 5853 - 5872
Опубликована: Янв. 1, 2022
As
a
group
of
chronic
and
idiopathic
gastrointestinal
(GI)
disorders,
inflammatory
bowel
disease
(IBD)
is
characterized
by
recurrent
intestinal
mucosal
inflammation.
Pharmaceutics,
Год журнала:
2022,
Номер
14(4), С. 822 - 822
Опубликована: Апрель 8, 2022
Inflammatory
bowel
disease
(IBD)
is
a
chronic
recurrent
intestinal
and
includes
Crohn's
(CD)
ulcerative
colitis
(UC).
Due
to
the
complex
etiology
of
colitis,
current
treatments
IBD
are
quite
limited
mainly
concentrated
on
remission
disease.
In
addition,
side
effects
conventional
drugs
body
cannot
be
ignored.
also
has
certain
relationship
with
colitis-associated
cancer
(CAC),
inflammatory
cells
can
produce
large
number
tumor-promoting
cytokines
promote
tumor
progression.
recent
years,
exosomes
from
plants
have
been
found
ability
load
target
intestine
great
potential
for
treatment
diseases.
This
plant-derived
exosome-targeting
delivery
system
chemical
or
nucleic
acid
deliver
them
sites
stably
efficiently.
review
summarizes
pathophysiological
characteristics
CAC
as
well
application
prospect
plant
in
CAC.
