Steering Piezocatalytic Therapy for Optimized Tumoricidal Effect

Advanced Functional Materials, Год журнала: 2024, Номер 34(33)

Опубликована: Май 16, 2024

Abstract Piezocatalysts, because of their mechano‐electrical conversion properties, are exploited for various medical applications, such as sterilization, tissue engineering, biosensing, and disease theranostics. In particular, based on the unique advantage piezoelectric effect, piezocatalytic therapy (PCT) has been developed a novel promising candidate tumor therapy. To optimize utilization piezocatalysts in therapy, comprehensive understanding antitumor mechanism associated with these materials is imperative. Here, action principle elucidated by investigating piezocatalysts, reactants, energy inputs, products. Subsequently, mechanisms PCT have extensively discussed recapitulative follows: restraining cell proliferation, inducing programmed death, hindering metastasis, inhibiting angiogenesis, enhancing immunity. Additionally, optimized therapeutic outcomes PCT‐centric synergistic cancer systematically described. Finally, main challenges future research directions piezocatalysis applied envisioned. It believed that will serve new‐generation ingenious tool treatment.

Язык: Английский

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Spatial features of specific CD103+CD8+ tissue-resident memory T cell subsets define the prognosis in patients with non-small cell lung cancer

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 5, 2024

Abstract Background Tissue-resident memory T (T RM ) cells can reside in the tumor microenvironment and are considered primary response to immunotherapy. Heterogeneity functional status spatial distribution may contribute controversial role of but we know little about it. Methods Through multiplex immunofluorescence (mIF) (CD8, CD103, PD-1, Tim-3, GZMB, CK), quantity location cell subsets were recognized tissue from 274 patients with NSCLC after radical surgery. By integrating multiple machine learning methods, constructed a -based immune signature -SIS) predict prognosis. Furthermore, conducted CD103-related gene set enrichment analysis (GSEA) verified its finding by another mIF panel CK, CD31, Hif-1α). Results The density was significantly correlated expression Tim-3 GZMB. Four types defined, including RM1 (PD-1 − ), RM2 + RM3 RM4 ). cytotoxicity strongest while that weakest. Compare , had better infiltration stronger interaction cancer cells. -SIS an independent prognostic factor for disease-free survival [HR = 2.43, 95%CI (1.63–3.60), P < 0.001] showed performance than TNM staging system recurrence prediction. GSEA validation, found negative association between angiogenesis Conclusions These findings reveal significant heterogeneity cells, support it as biomarker prognosis patients. Regulating targeting be potential strategy improve current

Язык: Английский

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Substrate stiffness modulates osteogenic and adipogenic differentiation of osteosarcoma through PIEZO1 mediated signaling pathway

Cellular Signalling, Год журнала: 2025, Номер 127, С. 111601 - 111601

Опубликована: Янв. 9, 2025

Язык: Английский

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Nanosensors in the food industry and agriculture

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 751 - 768

Опубликована: Янв. 1, 2025

Язык: Английский

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Harnessing phytochemicals: innovative strategies to enhance cancer immunotherapy

Drug Resistance Updates, Год журнала: 2025, Номер 79, С. 101206 - 101206

Опубликована: Фев. 1, 2025

Cancer immunotherapy has revolutionized cancer treatment, but therapeutic ineffectiveness-driven by the tumor microenvironment and immune evasion mechanisms-continues to limit its clinical efficacy. This challenge underscores need explore innovative approaches, such as multimodal immunotherapy. Phytochemicals, bioactive compounds derived from plants, have emerged promising candidates for overcoming these barriers due their immunomodulatory antitumor properties. review explores synergistic potential of phytochemicals in enhancing modulating responses, reprogramming microenvironment, reducing immunosuppressive factors. Integrating with conventional strategies represents a novel approach mitigating resistance outcomes. For instance, nab-paclitaxel shown checkpoint inhibitors, while QS-21 synergistically enhances efficacy vaccines. Furthermore, we highlight recent advancements leveraging nanotechnology engineer improved bioavailability targeted delivery. These innovations hold great promise optimizing application phytochemicals. However, further large-scale studies are crucial fully integrate into immunotherapeutic regimens effectively.

Язык: Английский

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Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 5, 2025

Hepatocellular carcinoma (HCC) is one of the most prevalent cancers, characterized by high morbidity and mortality rates. Recently, immunotherapy has emerged as a crucial treatment modality for HCC, following surgery, locoregional therapies, targeted therapies. This approach harnesses body's immune system to target eliminate cancer cells, potentially resulting in durable antitumor responses. However, acquired resistance tumor immunosuppressive microenvironment (TIME) significantly hinder its clinical application. advancements nanotechnology, coupled with deeper understanding biology nano-biological interactions, have led development various nanoparticles aimed at enhancing therapeutic efficacy through specific targeting tissues. These increase accumulation immunotherapeutic drugs within microenvironment, thereby transforming TIME. In this review, we provide concise overview fundamental principles governing TIME landscape HCC discuss rationale applications context. Additionally, highlight existing challenges potential opportunities translation nanomedicines.

Язык: Английский

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Link of sorafenib resistance with the tumor microenvironment in hepatocellular carcinoma: Mechanistic insights

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Авг. 22, 2022

Sorafenib, a multi-kinase inhibitor with antiangiogenic, antiproliferative, and proapoptotic properties, is the first-line treatment for patients late-stage hepatocellular carcinoma (HCC). However, therapeutic effect remains limited due to sorafenib resistance. Only about 30% of HCC respond well treatment, resistance almost inevitably happens within 6 months. Thus, it critical elucidate underlying mechanisms identify effective approaches improve outcome. According recent studies, tumor microenvironment (TME) immune escape play roles in occurrence, metastasis anti-cancer drug The relevant were focusing on hypoxia, tumor-associated immune-suppressive cells, immunosuppressive molecules. In this review, we focus its relationship liver cancer microenvironment, highlighting importance breaking HCC.

Язык: Английский

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Collagen code in tumor microenvironment: Functions, molecular mechanisms, and therapeutic implications

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 166, С. 115390 - 115390

Опубликована: Сен. 4, 2023

The tumor microenvironment (TME) is crucial in cancer progression, and the extracellular matrix (ECM) an important TME component. Collagen a major ECM component that contributes to cell infiltration, expansion, distant metastasis during progression. Recent studies reported collagen deposited form wall along which cells can infiltrate prevent drugs from working on cells. Collagen-tumor interaction complex requires activation of multiple signaling pathways for biochemical mechanical interventions. In this review, we examine effect deposition progression discuss between This review aims illustrate functions mechanisms its role therapy. findings indicated appears be better target

Язык: Английский

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Combination Therapy of Lox Inhibitor and Stimuli‐Responsive Drug for Mechanochemically Synergistic Breast Cancer Treatment

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(21)

Опубликована: Апрель 26, 2023

Chemotherapy based on small molecule drugs, hormones, cycline kinase inhibitors, and monoclonal antibodies has been widely used for breast cancer treatment in the clinic but with limited efficacy, due to poor specificity tumor microenvironment (TME)-caused diffusion barrier. Although monotherapies targeting biochemical cues or physical TME have developed, none of them can cope complex TME, while mechanochemical combination therapy remains largely be explored. Herein, a strategy an extracellular matrix (ECM) modulator TME-responsive drug first attempt mechanochemically synergistic is developed. Specifically, overexpressed NAD(P)H quinone oxidoreductase 1 (NQO1) cancer, (NQO1-SN38) designed it combined inhibitor (i.e., β-Aminopropionitrile, BAPN) Lysyl oxidases (Lox) that contributes stiffness, therapy. It demonstrated NQO1 trigger degradation NQO1-SN38 release SN38, showing nearly twice inhibition efficiency compared SN38 vitro. Lox BAPN significantly reduces collagen deposition enhances penetration heterospheroids further showed outstanding therapeutic efficacy vivo, providing promising approach

Язык: Английский

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Non‐Pore Dependent and MMP‐9 Responsive Gelatin/Silk Fibroin Composite Microparticles as Universal Delivery Platform for Inhaled Treatment of Lung Cancer

Advanced Materials, Год журнала: 2023, Номер 35(42)

Опубликована: Авг. 25, 2023

Developing a drug delivery platform that possesses universal loading capacity to meet various requirements of cancer treatment is challenging yet interesting task. Herein, self-assembled gelatin/silk fibroin composite (GSC) particle based system developed via microphase separation followed by desolvation process. Thanks its preassembled stage, this GSC suitable for varying types drugs. The process fix drugs inside rapidly and densify the structure, thereby achieving efficient providing comprehensive protection loaded Actually, size brand-new non-pore dependent can be easily adjusted from 100 nm 20 µm fit different scenarios. This work selects with 3 diameter as inhaled platform, which shows an excellent transmucosal penetration lung retention ability. Additionally, MMP-9 sensitive degradation property enhances targeted efficiency reduces side effects. Intestinally, self-amplify regulation innate immunity reverse cancerous microenvironment into antitumor niche, significantly improving therapeutic effect study provides new direction develop next-generation cancer.

Язык: Английский

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