Stealth and pseudo-stealth nanocarriers

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 198, С. 114895 - 114895

Опубликована: Май 19, 2023

Язык: Английский

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Tumor Abnormality-Oriented Nanomedicine Design

Chemical Reviews, Год журнала: 2023, Номер 123(18), С. 10920 - 10989

Опубликована: Сен. 15, 2023

Anticancer nanomedicines have been proven effective in mitigating the side effects of chemotherapeutic drugs. However, challenges remain augmenting their therapeutic efficacy. Nanomedicines responsive to pathological abnormalities tumor microenvironment (TME) are expected overcome biological limitations conventional nanomedicines, enhance efficacies, and further reduce effects. This Review aims quantitate various TME, which may serve as unique endogenous stimuli for design stimuli-responsive provide a broad objective perspective on current understanding cancer treatment. We dissect typical transport process barriers drug delivery, highlight key principles designed tackle series delivery process, discuss "all-into-one" "one-for-all" strategies integrating needed properties nanomedicines. Ultimately, we insight into future perspectives toward clinical translation

Язык: Английский

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Targeting endothelial permeability in the EPR effect

Journal of Controlled Release, Год журнала: 2023, Номер 361, С. 212 - 235

Опубликована: Авг. 8, 2023

Язык: Английский

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Recent advances of plant-mediated metal nanoparticles: Synthesis, properties, and emerging applications for wastewater treatment

Journal of environmental chemical engineering, Год журнала: 2024, Номер 12(2), С. 112345 - 112345

Опубликована: Фев. 28, 2024

Язык: Английский

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mRNA nanodelivery systems: targeting strategies and administration routes

Biomaterials Research, Год журнала: 2023, Номер 27(1)

Опубликована: Фев. 9, 2023

With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid (mRNA) vaccines, mRNA therapeutics have gained significant momentum for prevention and treatment various refractory diseases. To function efficiently in vivo overcome clinical limitations, demands safe stable vectors a reasonable administration route, bypassing multiple biological barriers achieving organ-specific targeted delivery mRNA. Nanoparticle (NP)-based systems representing leading vector approaches ensure successful intracellular to target organ. In this review, chemical modifications types advanced NPs, including lipid NPs polymers are summarized. The importance passive targeting, especially endogenous active targeting nano-delivery is emphasized, different cellular endocytic mechanisms discussed. Most importantly, based on above content physiological structure characteristics organs vivo, design strategies cells classified Furthermore, influence routes highlighted. Finally, an outlook remaining challenges future development toward therapies precision medicine provided.

Язык: Английский

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Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery

Advanced Science, Год журнала: 2024, Номер 11(14)

Опубликована: Янв. 28, 2024

Abstract Intracellular delivery of nano‐drug‐carriers (NDC) to specific cells, diseased regions, or solid tumors has entered the era precision medicine that requires systematic knowledge nano‐biological interactions from multidisciplinary perspectives. To this end, review first provides an overview membrane‐disruption methods such as electroporation, sonoporation, photoporation, microfluidic delivery, and microinjection with merits high‐throughput enhanced efficiency for in vitro NDC delivery. The impact characteristics including particle size, shape, charge, hydrophobicity, elasticity on cellular uptake are elaborated several types systems aiming hierarchical targeting vivo reviewed. Emerging ex human/animal‐derived pathophysiological models further explored highly recommended use studies since they might mimic features fill translational gaps animals humans. exploration modern microscopy techniques precise nanoparticle (NP) tracking at cellular, organ, organismal levels informs tailored development NDCs application clinical translation. Overall, integrates latest insights into smart nanosystem engineering, physiological models, imaging‐based validation tools, all directed towards enhancing efficient intracellular NDCs.

Язык: Английский

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PEGylated nanoparticles interact with macrophages independently of immune response factors and trigger a non-phagocytic, low-inflammatory response

Journal of Controlled Release, Год журнала: 2024, Номер 366, С. 282 - 296

Опубликована: Янв. 4, 2024

Язык: Английский

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Lipid Nanoparticle-Based Delivery System─A Competing Place for mRNA Vaccines

ACS Omega, Год журнала: 2024, Номер 9(6), С. 6219 - 6234

Опубликована: Янв. 30, 2024

mRNA, as one of the foci biomedical research in past decade, has become a candidate vaccine solution for various infectious diseases and tumors regenerative medicine immunotherapy due to its high efficiency, safety, effectiveness. A stable effective delivery system is needed protect mRNAs from nuclease degradation while also enhancing immunogenicity. The success mRNA lipid nanoparticles treating COVID-19, certain extent, marks milestone vaccines promotes further on systems. Here, we explore systems, especially (LNPs), considering current status, prospects, challenges nanoparticles, other

Язык: Английский

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Cellular internalization pathways of environmentally exposed microplastic particles: Phagocytosis or Macropinocytosis?

Journal of Hazardous Materials, Год журнала: 2025, Номер 489, С. 137647 - 137647

Опубликована: Фев. 17, 2025

Microplastic particles (MP) ubiquitously occur in all environmental compartments where they interact with biomolecules, forming an eco-corona on their surfaces. The affects the surface properties of MP and consequently how cells. Proteins, integral component within eco-corona, may serve as a ligand driving interaction membrane receptors. To date, it is not known, whether eco-coronae originating from different media differ proteinaceous compositions these differently We show that protein composition formed freshwater (FW) salt water (SW) are distinct each other. did observe adhesion strengths between coated However, internalization efficiency underlying mechanisms significantly differed FW- SW eco-coronae. By inhibiting actin-driven receptor-mediated processes using Cytochalasin-D, Amiloride, Amantadine, we FW microplastic predominantly become internalized via phagocytosis, while macropinocytosis more important for particles. Overall, our findings origin coatings factors cellular This highlights relevance adverse effects environmentally relevant cells organisms.

Язык: Английский

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Mechanisms of receptor-mediated transcytosis at the blood-brain barrier

Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113595 - 113595

Опубликована: Март 6, 2025

In receptor-mediated transcytosis (RMT) of large therapeutics across the blood-brain barrier (BBB), construct - a macromolecule or larger carrier with therapeutic payload binds protein on brain capillary endothelial cells (BCEC), internalization and release into parenchyma. The construct's into, trafficking from, but also possible entrapment within BCEC are affected by its engineered properties whose optimization has helped derive insights transport mechanisms at BCEC. Furthermore, advances in multi-omics, as well large-scale screening directed evolution campaigns have identify new targets for RMT this perspective, I raise reflect some fundamental questions one can arrive comparing BBB-targeted constructs different target proteins. These concern underlying, transcytosis-promoting factors that constructs' appears to converge on, precise role proteins RMT, through which these may mediate trafficking, tentative criteria selection Based considerations propose several scenarios strategies interfere more efficient internalization, endosomal network toward abluminal membrane, from BCEC, both smaller macromolecules carriers.

Язык: Английский

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