International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 8929 - 8947
Опубликована: Сен. 1, 2024
Introduction:
Cell
death
regulation
holds
a
unique
value
in
the
field
of
cancer
therapy.
Recently,
disulfidptosis
has
garnered
substantial
scientific
attention.
Previous
studies
have
reported
that
sonodynamic
therapy
(SDT)
based
on
reactive
oxygen
species
(ROS)
can
regulate
cell
death,
achieving
an
limited
anti-cancer
effect.
However,
integration
SDT
with
as
strategy
not
been
extensively
developed.
In
this
study,
we
constructed
artificial
membrane
sonosensitizer,
specifically,
nanoliposome
(SC@lip)
coated
combination
chemotherapy
medicine
Sorafenib
(Sora)
and
sonosensitizer
Chlorin
e6
(Ce6),
to
realize
one-stop
enhanced
effect
induces
disulfidptosis-like
death.
Methods:
Ce6
were
co-encapsulated
into
PEG-modified
liposomes,
SC@Lip
was
using
simple
rotary
evaporation
phacoemulsification
method.
The
phagocytosis,
ROS
generation
ability,
glutathione
(GSH)
depletion
lipid
peroxidation
(LPO),
mediated
by
under
ultrasound
(US)
irradiation
evaluated.
Based
4T1
subcutaneous
tumor
model,
both
vivo
biological
safety
assessment
efficacy
assessed.
Results:
exhibits
high
efficiency
cellular
phagocytosis.
After
being
endocytosed
cells,
abundant
produced
activation,
survival
rates
below
5%.
When
applied
inhibited
growth
prolonged
time
mice.
vitro
experiments
show
enhance
trigger
thus
anti-tumor
vivo.
Conclusion:
is
multifunctional
nanoplatform
membrane,
which
integrate
functions
sonosensitization
GSH
biocompatible
nanoplatform,
be
used
promote
Keywords:
disulfidptosis,
therapy,
species,
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 5523 - 5544
Опубликована: Июнь 1, 2024
Metal-organic
frameworks
(MOFs)
are
porous
materials
resulting
from
the
coordination
of
metal
clusters
or
ions
with
organic
ligands,
merging
macromolecular
and
chemistry
features.
Among
these,
zeolitic
imidazolate
framework-8
(ZIF-8)
stands
out
as
a
widely
utilized
MOF
known
for
its
robust
stability
in
aqueous
environments
owing
to
interaction
between
constituent
zinc
(Zn
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(4), С. 1789 - 1822
Опубликована: Янв. 1, 2024
This
review
discusses
the
balance
of
inflammation
in
immunity
and
biomaterials
strategies
to
modulate
cases
imbalance
such
as
autoimmune
disease,
infection,
cancer.
Adapted
from
“Balanced
Energy
State”,
by
BioRender.com
(2023).
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Март 29, 2024
Abstract
The
deployment
of
imaging
examinations
has
evolved
into
a
robust
approach
for
the
diagnosis
lymph
node
metastasis
(LNM).
advancement
technology,
coupled
with
introduction
innovative
drugs,
led
to
incorporation
an
increasingly
diverse
array
techniques
clinical
practice.
Nonetheless,
conventional
methods
administering
agents
persist
in
presenting
certain
drawbacks
and
side
effects.
employment
controlled
drug
delivery
systems
(DDSs)
as
conduit
transporting
offers
promising
solution
ameliorate
these
limitations
intrinsic
metastatic
(LN)
imaging,
thereby
augmenting
diagnostic
precision.
Within
scope
this
review,
we
elucidate
historical
context
LN
encapsulate
frequently
employed
DDSs
conjunction
variety
techniques,
specifically
imaging.
Moreover,
engage
discourse
on
conceptualization
practical
application
fusing
treatment
by
employing
DDSs.
Finally,
venture
prospective
applications
realm
LNM
share
our
perspective
potential
trajectory
DDS
development.
Graphical
iScience,
Год журнала:
2024,
Номер
27(4), С. 109350 - 109350
Опубликована: Фев. 27, 2024
Colorectal
cancer
(CRC)
ranks
as
the
second
leading
cause
of
cancer-related
mortality,
with
metastasis
being
primary
determinant
poor
prognosis
in
patients.
Investigating
molecular
mechanisms
underlying
CRC
is
currently
a
prominent
and
challenging
area
research.
Exosomes,
crucial
intercellular
communication
mediators,
facilitate
transfer
metabolic
genetic
information
from
cells
origin
to
recipient
cells.
Their
roles
mediating
exchange
between
immune
cells,
fibroblasts,
other
cell
types
are
pivotal
reshaping
tumor
microenvironment,
regulating
key
biological
processes
such
invasion,
migration,
formation
pre-metastatic
niche.
This
article
comprehensively
examines
function
mechanism
exosomes
derived
different
metastasis,
while
also
presenting
an
outlook
on
current
research
advancements
future
application
prospects.
The
aim
offer
distinctive
perspective
that
contributes
accurate
diagnosis
rational
treatment
strategies
for
CRC.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 12, 2024
Endothelial
cells
(ECs)
are
pivotal
in
maintaining
vascular
health,
regulating
hemodynamics,
and
modulating
inflammatory
responses.
Nanocarriers
hold
transformative
potential
for
precise
drug
delivery
within
the
system,
particularly
targeting
ECs
therapeutic
purposes.
However,
complex
interactions
between
nanocarriers
present
significant
challenges
development
clinical
translation
of
nanotherapeutics.
This
review
assesses
recent
advancements
key
strategies
employing
to
ECs.
It
suggested
that
through
physicochemical
design
surface
modifications,
can
enhance
specificity
improve
internalization
efficiency
Additionally,
we
elaborated
on
applications
specifically
designed
treatment
cardiovascular
diseases,
cancer
metastasis,
disorders.
Despite
these
advancements,
safety
concerns,
complexity
vivo
processes,
challenge
achieving
subcellular
remain
obstacles
effective
with
nanocarriers.
A
comprehensive
understanding
endothelial
cell
biology
its
interaction
is
crucial
realizing
full
targeted
systems.
Recent
advances
in
the
development
of
tumor-targeting
nanoparticles
(NPs)
significantly
enhance
cancer
therapies
by
effectively
increasing
therapeutic
window
drugs,
improving
response
tumor
cells,
and
augmenting
anti-tumor
immunity.
However,
understanding
process
remains
elusive
because
complex
vivo
behavior
nanoparticles.
Various
factors
are
reported
to
alter
this
process;
however,
systematic
studies
on
mechanisms
remain
limited.
In
review,
an
overview
current
strategies
for
targeting
their
applications
chemotherapy
immunotherapy,
with
a
focus
advancement
various
barriers
effective
penetration
is
provided.
Clinical and Experimental Medicine,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 5, 2025
Abstract
Inflammatory
bowel
disease
(IBD)
is
a
multifactorial
illness
with
climbing
prevalence
worldwide.
While
biologics
are
commonly
prescribed
especially
for
severe
cases,
they
may
worsen
patients’
outcomes
due
to
financial
burden.
Consequently,
there
has
been
an
increased
focus
on
biosimilars
improve
overall
by
maintaining
similar
efficacy
and
safety
while
minimizing
the
cost
of
therapy.
Infliximab-dyyb
was
first
biosimilar
approved
US-FDA
IBD.
Since
that,
14
different
mechanisms
action
routes
administration
IBD
patients
(four
infliximab
biosimilars,
nine
adalimumab
most
recently
one
ustekinumab
biosimilar).
It
should
be
noted
that
more
in
pipeline
as
golimumab
natalizumab
patents
set
expire
near
future,
now
pre-clinical
phase
3
trials.
Different
studies
have
evaluated
biologics'
effectiveness
concluded
majority
available
efficacious
adverse
effect
profiles
compared
their
reference
biologics.
worth
mentioningthat
post-marketing
surveillance
reports
revealed
some
risks
associated
which
taken
into
consideration
future
research
clinical
trials
avoid
health
hazards.
Most
administered
parenterally
results
several
drawbacks
such
raised
risk
infections,
hypersensitivity,
autoimmunity,
development
malignancies,
liver
toxicity
well
worsening
heart
failure.
Several
drug
delivery
systems
based
passive
active
targeting
under
investigation
overcome
these
limitations.
This
review
sheds
light
emergence
alternatives
management,
differences
between
them,
challenges
risks,
perspectives
therapy
new
trends
systems.
Graphical
Molecules,
Год журнала:
2024,
Номер
29(10), С. 2393 - 2393
Опубликована: Май 19, 2024
The
rapid
advancements
in
nanotechnology
the
field
of
nanomedicine
have
potential
to
significantly
enhance
therapeutic
strategies
for
cancer
treatment.
There
is
considerable
promise
enhancing
efficacy
therapy
through
manufacture
innovative
nanocomposite
materials.
Metallic
nanoparticles
been
found
release
anticancer
medications
that
are
loaded
onto
them,
resulting
a
sustained
release,
hence
reducing
dosage
required
drug
administration
and
preventing
their
buildup
healthy
cells.
combination
with
biocompatible
materials
offers
new
prospects
development
advanced
therapies
exhibit
enhanced
selectivity,
reduced
adverse
effects,
improved
patient
outcomes.
Chitosan
(CS),
polysaccharide
possessing
distinct
physicochemical
properties,
exhibits
favorable
attributes
controlled
delivery
due
its
biocompatibility
biodegradability.
nanocomposites
heightened
stability,
biocompatibility,
prolonged
characteristics
medicines.
incorporation
gold
(Au)
into
chitosan
results
manifestation
photothermal
characteristics,
whereas
inclusion
silver
(Ag)
boosts
antibacterial
capabilities
synthesized
nanocomposite.
objective
this
review
investigate
recent
progress
utilization
Ag
Au
nanoparticles,
or
thereof,
within
matrix
modified
derivatives
purpose
delivery.
research
findings
deliver
various
drugs,
such
as
doxorubicin,
5-Fluroacil,
curcumin,
paclitaxel,
6-mercaptopurine,
were
investigated.
Moreover,
modifications
carried
out
on
phase
surfaces
targeting
loading
efficiency,
pH
sensitivity
highlighted.
In
addition,
challenges
perspectives
could
motivate
further
related
applications
summarized.
Communications Chemistry,
Год журнала:
2024,
Номер
7(1)
Опубликована: Авг. 13, 2024
Abstract
Mitochondrial
dysregulation
plays
a
significant
role
in
the
carcinogenesis.
On
other
hand,
its
destabilization
strongly
represses
viability
and
metastatic
potential
of
cancer
cells.
Photodynamic
photothermal
therapies
(PDT
PTT)
target
mitochondria
effectively,
providing
innovative
non-invasive
anticancer
therapeutic
modalities.
Cyanine
dyes,
with
strong
mitochondrial
selectivity,
show
enhancing
PDT
PTT.
The
limitations
cyanine
dyes
for
PTT
are
discussed,
along
their
applications
combination
therapies,
theranostic
techniques,
optimal
delivery
systems.
Additionally,
novel
approaches
sonodynamic
therapy
using
photoactive
presented,
highlighting
advances
treatment.
