Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 91, С. 105270 - 105270
Опубликована: Дек. 14, 2023
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 251, С. 126390 - 126390
Опубликована: Авг. 16, 2023
Язык: Английский
Процитировано
34
Pharmaceutics, Год журнала: 2023, Номер 15(7), С. 1985 - 1985
Опубликована: Июль 20, 2023
The present study investigates the brain-targeted efficiency of atomoxetine (AXT)-loaded nanostructured lipid carrier (NLC)-laden thermosensitive in situ gel after intranasal administration. AXT-NLC was prepared by melt emulsification ultrasonication method and optimized using Box–Behnken design (BBD). formulation (AXT-NLC) exhibited particle size PDI, zeta potential, entrapment (EE) 108 nm, 0.271, −42.3 mV, 84.12%, respectively. morphology found to be spherical, as confirmed SEM analysis. DSC results displayed that AXT encapsulated within NLC matrix. Further, (AXT-NLC13) incorporated into a poloxamer 407 carbopol gelling agent evaluated for different parameters. (AXT-NLC13G4) showed excellent viscosity (2532 ± 18 Cps) at 37 °C formed 28–34 °C. AXT-NLC13-G4 sustained release (92.89 3.98% 12 h) compared pure (95.47 2.76% 4 h). permeation flux through goat nasal mucosa from 504.37 µg/cm2·h 232.41 µg/cm2·h, intranasally significantly higher absolute bioavailability (1.59-fold higher) than intravenous 51.91% BTP (28.64%) when administered via same route (intranasally). BTE (207.92%) (140.14%) intranasally, confirming high amount reached brain. With disrupted performance induced L-methionine, (p < 0.05) better activity well donepezil (standard). finding concluded is novel improvement brain delivery requires further investigation more justification.
Язык: Английский
Процитировано
27
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 245, С. 125554 - 125554
Опубликована: Июнь 24, 2023
Язык: Английский
Процитировано
26
Pharmaceutics, Год журнала: 2023, Номер 16(1), С. 58 - 58
Опубликована: Дек. 29, 2023
Alzheimer's disease, a progressive neurodegenerative condition, is characterized by gradual decline in cognitive functions. Current treatment approaches primarily involve the administration of medications through oral, parenteral, and transdermal routes, aiming to improve function alleviate symptoms. However, these treatments face limitations, such as low bioavailability inadequate permeation. Alternative invasive methods, while explored, often entail discomfort require specialized assistance. Therefore, development non-invasive efficient delivery system crucial. Intranasal has emerged potential solution, although it constrained unique conditions nasal cavity. An innovative approach involves use nano-carriers based on nanotechnology for intranasal delivery. This strategy overcome current limitations providing enhanced bioavailability, improved permeation, effective traversal blood-brain barrier, extended retention within body, precise targeting brain. The comprehensive review focuses advancements designing various types nano-carriers, including polymeric nanoparticles, metal lipid liposomes, nanoemulsions, Quantum dots, dendrimers. These are specifically tailored therapeutic agents aimed at combatting disease. In summary, utilization systems show significant surmounting constraints disease strategies. Nevertheless, essential acknowledge regulatory well toxicity concerns associated with this route; meticulous consideration required when engineering carrier. underscores revolutionize management highlights importance addressing considerations safe implementations. Embracing could lead substantial field treatment.
Язык: Английский
Процитировано
24
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Март 23, 2023
Cancer causes significant mortality and morbidity worldwide, but existing pharmacological treatments are greatly limited by the inherent heterogeneity of cancer as a disease, well unsatisfactory efficacy specificity therapeutic drugs. Biopharmaceutical barriers such low permeability poor water solubility, along with absence active targeting capabilities, often result in suboptimal clinical results. The difficulty successfully reaching destroying tumor cells is also compounded undesirable impacts on healthy tissue, including off-target effects high toxicity, which further impair ability to effectively manage disease optimize patient outcomes. However, last few decades, development nanotherapeutics has allowed for use rational design order maximize success. Advances fabrication nano-sized delivery systems, coupled variety surface engineering strategies promote customization, have resulted promising approaches targeted, site-specific drug fewer unwanted better efficacy. These nano systems been able overcome some challenges conventional related pharmacokinetics, biodistribution, target specificity. In particular, lipid-based nanosystems extensively explored due their biocompatibility, versatility, adaptability. Lipid-based treatment varied diverse, liposomal therapeutics, lipidic nanoemulsions, solid lipid nanoparticles, nanostructured carriers, lipid-polymer nanohybrids, supramolecular nanolipidic structures. This review aims provide an overview diverse formulations lipid-engineered current field, researchers attempt translate these from bench clinic.
Язык: Английский
Процитировано
23
Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(10), С. 105968 - 105968
Опубликована: Авг. 17, 2024
Hydrogels are three-dimensional structures that serve as substitutes for the extracellular matrix (ECM) and possess outstanding physicochemical biochemical characteristics. They gaining importance in regenerative medicine because of their similarity to natural terms moisture content wound tissue healing permeability. Tissue engineering advancements have resulted development flexible hydrogels mimic dynamic characteristics ECM. Several approaches been applied produce from biopolymers with enhanced functional structural different applications (TERM). This review provides a comprehensive overview hydrogel healing, engineering, drug delivery systems. We outline types based on physical chemical crosslinking, fundamental properties, TERM. article provided recent literature within five years. Recent developments biopolymer-based state-of-the-art discussed, emphasizing significant challenges future perspectives.
Язык: Английский
Процитировано
15
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(11), С. 4683 - 4716
Опубликована: Сен. 2, 2024
About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.
Язык: Английский
Процитировано
14
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 2441 - 2467
Опубликована: Март 1, 2024
Abstract: New nanotechnology strategies for enhancing drug delivery in brain disorders have recently received increasing attention from designers. The treatment of neurological conditions, including tumors, stroke, Parkinson's Disease (PD), and Alzheimer's disease (AD), may be greatly influenced by nanotechnology. Numerous studies on neurodegeneration demonstrated the effective application nanomaterials illnesses. Nanocarriers (NCs) made it easier to deliver drugs precisely where they are needed. Thus, most use is various diseases, as this amplifies overall impact medication emphasizes significance nanotherapeutics through gene therapy, enzyme replacement blood-barrier mechanisms. Recent advances led development multifunctional nanotherapeutic agents, a promising disorders. This novel method reduces side effects improves outcomes. review critically assesses efficient nano-based systems light obstacles outstanding achievements. that transfer medications across blood-brain barrier nano-assisted therapies, nano-immunotherapy, nano-gene nano scaffolds, 3D 6D printing, been widely explored study aimed evaluate existing literature regarding can penetrate (BBB) therapeutic agents treat Keywords: delivery, nanomedicine, nano-therapeutics, nanocarriers,
Язык: Английский
Процитировано
13
ACS Applied Bio Materials, Год журнала: 2024, Номер 7(6), С. 3535 - 3555
Опубликована: Май 20, 2024
Alzheimer's disease (AD) is a neurological condition currently with 47 million people suffering from it globally. AD might have many reasons such as genetic issues, environmental factors, and Aβ accumulation, which the biomarker of disease. Since primary reason unknown, there no targeted treatment at moment, but ongoing research aims to slow its progression by managing amyloid-beta peptide production rather than symptomatic improvement. phytochemicals been demonstrated possess antioxidant, anti-inflammatory, neuroprotective properties, they may target multiple pathological factors can reduce risk Curcumin, phytochemical found in turmeric known for free radical scavenging an antiamyloid treating AD, has come under investigation. Although low bioavailability limits efficacy, prominent drug delivery system (DDS) desired overcome it. Hence, potency lipid-based nanoparticles encapsulating curcumin (LNPs-CUR) considered this study promising DDS. In vivo studies animal models indicate LNPs-CUR effectively amyloid plaque formation, leading cognitive enhancement reduced toxicity compared CUR. However, deeper understanding CUR's pharmacokinetics safety profile crucial before be medicine. Future investigations explore combination NPs other therapeutic agents increase their efficacy cases. This review provides current position CUR therapy paradigm, DDS suggestions CUR, previous point analytical view focused on advantages challenges.
Язык: Английский
Процитировано
10
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(12), С. 9243 - 9279
Опубликована: Июль 4, 2024
Язык: Английский
Процитировано
8