Cell Proliferation,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
The
global
increase
in
the
aging
population
has
led
to
a
concurrent
rise
incidence
of
age-related
diseases,
posing
substantial
challenges
healthcare
systems
and
affecting
well-being
elderly.
Identifying
securing
effective
treatments
become
an
urgent
priority.
In
this
context,
mesenchymal
stem
cell-derived
exosomes
(MSC-Exos)
have
emerged
as
promising
innovative
modality
field
anti-aging
medicine,
offering
multifaceted
therapeutic
approach.
MSC-Exos
demonstrate
significant
potential
due
their
immunomodulatory
anti-inflammatory
properties,
ability
inhibit
oxidative
stress,
reparative
effects
on
senescent
tissues.
These
attributes
make
them
valuable
combating
range
conditions
associated
with
aging,
such
cardiovascular
neurodegeneration,
skin
osteoarthritis.
integration
membrane-penetrating
peptides
introduces
novel
strategy
for
delivery
biomolecules,
surmounting
traditional
cellular
barriers
enhancing
efficacy.
This
review
provides
comprehensive
synthesis
current
understanding
MSC-Exos,
underscoring
role
potent
against
intricate
diseases.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 25, 2024
Depression
is
a
chronic
mental
disorder
characterized
by
persistent
low
mood
and
loss
of
interest.
Treatments
for
depression
are
varied
but
may
not
be
sufficient
cure.
Drug-based
treatment
regimens
have
drawbacks
such
as
slow
onset
action,
bioavailability,
drug
side
effects.
Nanocarrier
Drug
Delivery
Systems
(NDDS)
has
received
increasing
attention
brain
delivery
since
it
assists
the
through
blood-brain
barrier
improves
which
beneficial
treating
depression.
Due
to
particle
size
physicochemical
properties
nanocarriers,
presents
promise
improve
stability
solubility
antidepressants,
thereby
enhancing
concentration.
Moreover,
ligand-modified
nanocarriers
can
taken
target
direct
medicines
release
system
reduce
The
purpose
present
review
provide
an
up-to-date
understanding
relevant
antidepressants
in
different
routes
ingestion,
lay
foundation
patients
with
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 352 - 352
Опубликована: Март 9, 2025
Pharmaceutical
3D
printing,
combined
with
nanomaterials
and
nanodevices,
presents
a
transformative
approach
to
precision
medicine
for
treating
neurological
diseases.
This
technology
enables
the
creation
of
tailored
dosage
forms
controlled
release
profiles,
enhancing
drug
delivery
across
blood−brain
barrier
(BBB).
The
integration
nanoparticles,
such
as
poly
lactic-co-glycolic
acid
(PLGA),
chitosan,
metallic
nanomaterials,
into
3D-printed
scaffolds
improves
treatment
efficacy
by
providing
targeted
prolonged
release.
Recent
advances
have
demonstrated
potential
these
systems
in
conditions
like
Parkinson’s
disease,
epilepsy,
brain
tumors.
Moreover,
printing
allows
multi-drug
combinations
personalized
formulations
that
adapt
individual
patient
needs.
Novel
approaches,
including
stimuli-responsive
systems,
on-demand
dosing,
theragnostics,
provide
new
possibilities
real-time
monitoring
disorders.
Despite
innovations,
challenges
remain
terms
scalability,
regulatory
approval,
long-term
safety.
future
perspectives
this
suggest
its
revolutionize
treatments
offering
patient-specific
therapies,
improved
penetration,
enhanced
outcomes.
review
discusses
current
state,
applications,
nanotechnology
treatment,
highlighting
need
further
research
overcome
existing
challenges.
Medicina,
Год журнала:
2024,
Номер
60(9), С. 1384 - 1384
Опубликована: Авг. 24, 2024
Nanomedicine
is
a
newer,
promising
approach
to
promote
neuroprotection,
neuroregeneration,
and
modulation
of
the
blood–brain
barrier.
This
review
includes
integration
various
nanomaterials
in
neurological
disorders.
In
addition,
gelatin-based
hydrogels,
which
have
huge
potential
due
biocompatibility,
maintenance
porosity,
enhanced
neural
process
outgrowth,
are
reviewed.
Chemical
modification
these
especially
with
guanidine
moieties,
has
shown
improved
neuron
viability
underscores
tailored
biomaterial
design
applications.
further
discusses
strategies
modulate
barrier—a
factor
critically
associated
effective
delivery
drugs
central
nervous
system.
These
advances
bring
supportive
solutions
solving
conditions
innovative
therapies
for
their
treatment.
Nanomedicine,
as
applied
neuroscience,
presents
significant
leap
forward
new
therapeutic
that
might
help
raise
treatment
management
disorders
much
better
levels.
Our
aim
was
summarize
current
state-of-knowledge
this
field.
Reviews in Medical Virology,
Год журнала:
2024,
Номер
34(5)
Опубликована: Сен. 1, 2024
ABSTRACT
Merkel
cell
polyomavirus
(MCPyV)
is
a
significant
contributor
to
the
development
of
carcinoma
(MCC),
an
aggressive
skin
cancer
with
high
recurrence
and
low
survival
rate.
In
fact,
it
deadliest
cancer.
The
precise
routes
transmission
for
MCPyV‐positive
MCC
remain
unclear,
but
several
factors
may
trigger
its
development.
Conventional
treatments
are
not
highly
effective,
especially
in
patients
metastasis,
clear
need
new
treatment
options.
Gene‐targeted
therapies
hold
great
promise
MCC,
including
use
siRNA
CRISPR/Cas
(C/Cas)
critically
none
have
yet
been
translated
into
clinical
trials.
Validating
this
approach
fact
that
products
already
FDA
licenced,
while
C/Cas
has
entered
trial,
albeit
conditions
other
than
MCC.
There
many
challenges
must
be
overcome
move
from
preclinical
research
clinic.
review,
we
provide
comprehensive
summary
current
understanding
particular
focus
on
status
gene‐targeted
therapies.
Additionally,
discuss
major
obstacles
impede
explore
future
prospects.
Nanoscale,
Год журнала:
2024,
Номер
16(32), С. 14994 - 15008
Опубликована: Янв. 1, 2024
Cancer
has
become
a
primary
global
health
concern,
which
prompted
increased
attention
towards
targeted
therapeutic
approaches
like
photothermal
therapy
(PTT).
The
unique
optical
and
magnetic
properties
of
nanodiamonds
(NDs)
have
made
them
versatile
nanomaterials
with
promising
applications
in
biomedicine.
This
comprehensive
review
focuses
on
the
potential
NDs
as
multifaceted
platform
for
anticancer
therapy,
mainly
focusing
their
dual
functionality
PTT
temperature
sensing.
highlighted
NDs'
ability
to
enhance
through
hybridization
or
modification,
underscoring
adaptability
delivering
small
molecule
reagents
effectively.
Furthermore,
NDs,
particularly
fluorescent
(FNDs)
negatively
charged
nitrogen-vacancy
centers,
enable
precise
monitoring,
enhancing
efficacy
treatment.
Integrating
FNDs
into
holds
promise
advancing
by
providing
valuable
insights
localized
variations
cell
death
mechanisms.
highlights
new
cancer
treatment
strategies,
showcasing
revolutionize
therapeutics
improve
patient
outcomes.
