Опубликована: Янв. 1, 2024
Язык: Английский
Advanced Materials, Год журнала: 2023, Номер unknown
Опубликована: Окт. 4, 2023
Abstract Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic acid drug (NAD) delivery. Although their clinical applications have achieved success, NAD delivery efficiency and safety still unsatisfactory, which are, to a large extent, due existence of multi‐level physiological barriers in vivo. It is important elucidate interactions between these LBNPs, will guide more rational design efficient with low adverse effects facilitate broader therapeutics. This review describes obstacles challenges biological at systemic, organ, sub‐organ, cellular, subcellular levels. The strategies overcome comprehensively reviewed, mainly including physically/chemically engineering LBNPs directly modifying by auxiliary treatments. Then potentials successful translation preclinical studies into clinic discussed. In end, forward look on manipulating protein corona (PC) addressed, may pull off trick overcoming those significantly improve efficacy LBNP‐based NADs
Язык: Английский
Процитировано
53
Materials Today Sustainability, Год журнала: 2024, Номер 26, С. 100709 - 100709
Опубликована: Фев. 14, 2024
Язык: Английский
Процитировано
18
Regenerative Biomaterials, Год журнала: 2023, Номер 10
Опубликована: Янв. 1, 2023
Abstract Ferroptosis, a completely new form of regulated cell death, is mainly caused by an imbalance between oxidative damage and reductive protection has shown great anti-cancer potential. However, existing small-molecule ferroptosis inducers have various limitations, such as poor water solubility, drug resistance low targeting ability, hindering their clinical applications. Nanotechnology provides opportunities for ferroptosis-driven tumor therapy. Especially, stimuli-responsive nanomaterials stand out among others been widely researched because unique spatiotemporal control advantages. Therefore, it’s necessary to summarize the application those in ferroptosis. Here, we describe physiological feature illustrate current challenges induce cancer Then, that are classified elaborated according external internal stimuli. Finally, future perspectives field proposed. We hope this review facilitates paving way design intelligent nano-ferroptosis inducers.
Язык: Английский
Процитировано
40
Bioactive Materials, Год журнала: 2023, Номер 32, С. 445 - 472
Опубликована: Окт. 26, 2023
Effective tumor treatment depends on optimizing drug penetration and accumulation in tissue while minimizing systemic toxicity. Nanomedicine has emerged as a key solution that addresses the rapid clearance of free drugs, but achieving deep into solid tumors remains elusive. This review discusses various strategies to enhance penetration, including manipulation microenvironment, exploitation both external internal stimuli, pioneering nanocarrier surface engineering, development innovative tactics for active penetration. One outstanding strategy is organelle-affinitive transfer, which exploits unique properties specific cell organelles heralds potentially transformative approach transcellular transfer Rigorous models are essential evaluate efficacy these strategies. The patient-derived xenograft (PDX) model gaining traction bridge between laboratory discovery clinical application. However, journey from bench bedside nanomedicines fraught with challenges. Future efforts should prioritize deepening our understanding nanoparticle-tumor interactions, re-evaluating EPR effect, exploring novel nanoparticle transport mechanisms.
Язык: Английский
Процитировано
40
Advanced Healthcare Materials, Год журнала: 2023, Номер 12(28)
Опубликована: Авг. 7, 2023
Abstract Cuproptosis, a kind of newly recognized cell death modality, shows enormous prospect in cancer treatment. The inducer cuproptosis has more advantages tumor therapy, especially that can trigger and chemodynamic therapy (CDT) simultaneously. However, is restricted to the deficiency intracellular copper ions nonspecific delivery copper‐based ionophores. Therefore, high level delivery, responsive release, utilizing synergistic‐function become key on cuproptosis‐based oncotherapy. In this work, cascade nanosystem constructed for enhanced CDT. weak acidic environment cells, DNA, zinc ions, Cu + release from nanosystem. Since having superior performance mediating both Fenton‐like reaction cuproptosis, released induces CDT efficiently, accompanied by 2+ generation. Then be converted into partially glutathione (GSH) supply loop ensure synergistic action. Meanwhile, consumption GSH also contributes return. Finally, DNA Zn form DNAzyme shear catalase‐related RNA, resulting accumulation hydrogen peroxide further enhancing combination therapy. These results provide promising nanotherapeutic platform may inspire design potential treatment based cuproptosis.
Язык: Английский
Процитировано
31
Nanomaterials, Год журнала: 2023, Номер 13(9), С. 1454 - 1454
Опубликована: Апрель 24, 2023
Nanotechnology has allowed for significant progress in architectural, artistic, archaeological, or museum heritage conservation repairing and preventing damages produced by deterioration agents (weathering, contaminants, biological actions). This review analyzes the current treatments using nanomaterials, including consolidants, biocides, hydrophobic protectives, mechanical resistance improvers, flame-retardants, multifunctional nanocomposites. Unfortunately, nanomaterials can affect human animal health, altering environment. Right now, it is a priority to stop analyze its advantages disadvantages. Therefore, aims are raise awareness about nanotoxicity risks during handling subsequent environmental exposure all those directly indirectly involved processes. It reports human-body interaction mechanisms provides guidelines controlling toxicity, mentioning toxicity research of main compounds emphasizing need provide more information morphological, structural, specific features that ultimately contribute understanding their toxicity. documents international organizations (European Commission, NIOSH, OECD, Countries Normative) worker protection, isolation, laboratory ventilation control, debris management. Furthermore, qualitative risk assessment methods, management strategies, dose focus/receptor relationship, besides latest trends masks gas emissions control devices, discussing
Язык: Английский
Процитировано
25
Coordination Chemistry Reviews, Год журнала: 2023, Номер 502, С. 215601 - 215601
Опубликована: Дек. 13, 2023
Язык: Английский
Процитировано
19
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6147 - 6147
Опубликована: Март 24, 2023
Accumulating evidence indicates that chronic exposure to a low level of pesticides found in diet affects the human gut-microbiota-blood-brain barrier (BBB) axis. This axis describes physiological and bidirectional connection between microbiota, intestinal (IB), BBB. Preclinical observations reported gut microbial alteration induced by pesticides, also known as dysbiosis, condition associated not only with gastrointestinal disorders but diseases affecting other distal organs, such However, interplay IB, BBB is still fully explored. In this review, we first consider similarities/differences these two barriers different pathways link microbiota better understand dialogue bacteria brain. We then discuss effects oral pesticide on gut-microbiota-BBB raise awareness danger exposure, especially during perinatal period (pregnant women offspring).
Язык: Английский
Процитировано
18
Deleted Journal, Год журнала: 2024, Номер unknown
Опубликована: Апрель 8, 2024
Biomimetic nanoparticles (BioM NPs) feature functionalization that imitates the biological surroundings, endowing them with structure and functioning. BioM NPs could be covered biologically sourced materials contain synthetic antigen-presenting cells structures. Whenever used in cancer diagnostics, outperform standard medications comparable non-BioM NPs, particularly regarding circulation time, tissue penetration, delivery, toxicity. The particles achieved extraordinary results by using cell material for which avoids difficult bottom-up approaches aim to emulate such intricate diverse components. One area of this rapidly developing research has gotten a lot interest is use treatment different cancers. However, best our knowledge, no published study primarily analysed current improvements therapy, taking into account most common tumours processes. As result, purpose present review address gap first. discussion will next go numerous recent advances therapy. This cover mechanics procedures as well their utilization therapeutics. paper then summarizes existing knowledge investigates limitations promise aims provide researchers an overview technological development It serves guide integrating future nanomedicine applications.
Язык: Английский
Процитировано
6
Environment & Health, Год журнала: 2024, Номер 2(4), С. 189 - 201
Опубликована: Март 19, 2024
Understanding the bioaccumulation of nanomaterials (NMs) by organisms is essential in evaluating their potential ecotoxicity. However, experimental determination substantially challenging, which spawned development prediction approaches via establishing models for various NMs. Conventional modeling approaches, such as biotic ligand model (BLM), partition coefficients, accumulation factor models, and quantitative structure–activity relationship (QSAR) were initially used application NMs, aiming to provide a reliable dose resource-saving way. These methods, are based on uptake patterns substances, probably lead deviated results due different behaviors In this study, currently developed evaluate NMs critically reviewed, with feasibilities limitations being analyzed. addition, recently machine learning amended have taken great efforts realizing biological providing silico predictions. Though data-driven approach has mechanism exploration, it may give insights into establishment critical feature identification.
Язык: Английский
Процитировано
5