Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 199, С. 114991 - 114991
Опубликована: Июль 4, 2023
Язык: Английский
Exploration, Год журнала: 2024, Номер 4(6)
Опубликована: Март 24, 2024
Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.
Язык: Английский
Процитировано
42
Coordination Chemistry Reviews, Год журнала: 2024, Номер 504, С. 215654 - 215654
Опубликована: Янв. 20, 2024
Язык: Английский
Процитировано
22
Polymer-Plastics Technology and Materials, Год журнала: 2024, Номер 64(4), С. 397 - 438
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
11
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Янв. 10, 2024
Abstract Radiotherapy (RT) is one of the important treatment modalities for non-small cell lung cancer (NSCLC). However, maximum radiation dose that NSCLC patient can receive varies little. Therefore, exploitation novel RT sensitization approaches a critical need clinical treatment. resistance in linked to tumor microenvironment (TME) hypoxia, cycle arrest and associated genetic alterations. Here, we designed method targeted delivery quercetin (QT) CeO 2 enhance sensitivity. We loaded QT into @ZIF-8-HA nanoparticles prevent its degradation circulatory system successfully delivered tumors. Under protection Zeolitic Imidazolate Framework-8 (ZIF-8), nanocomplexes exhibited excellent catalytic mimetic activity decomposing H O , thus significantly reversing hypoxia TME, while radiosensitizer caused DNA damage directly after RT. In subcutaneous model, overcame enhanced therapeutic efficacy. This multiple strategy combining nanozymes opens promising approach NSCLC.
Язык: Английский
Процитировано
8
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161412 - 161412
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Artificial Cells Nanomedicine and Biotechnology, Год журнала: 2024, Номер 52(1), С. 122 - 129
Опубликована: Фев. 5, 2024
Locally advanced head and neck squamous cell carcinoma (LA-HNSCC) is characterized by high rate of recurrence, resulting in a poor survival. Standard treatments are associated with significant toxicities that impact the patient's quality life, highlighting urgent need for novel therapies to improve patient outcomes. On this regard, noble metal nanoparticles (NPs) emerging as promising agents both drug carriers radiosensitizers. other hand, co-treatments based on NPs still at preclinical stage because metal-persistence.
Язык: Английский
Процитировано
4
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Июнь 1, 2024
In this paper, we introduce a theoretical framework for optical trapping that integrates nonlinear polarization within the dipole approximation. This theory represents most comprehensive analytic model to date capable of resolving discrepancies between observed and simulated plasmonic nanoparticles. Our elucidates how two-photon absorption can account stable gold nanoparticles, including their longitudinal stability, especially near plasmon resonance. Furthermore, experimentally split potential wells in transverse plane, which are attributed absorption, close agreement with our model's predictions. Finally, study provides new insights into mechanism under conditions intense light-matter interactions.
Язык: Английский
Процитировано
3
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 13, 2025
Abstract The immune system provides defense against foreign agents that are considered harmful for the organism. Inorganic nanomaterials can be recognized by as antigens, inducing an reaction dependent on patient's immunological anamnesis and from several factors including size, shape, chemical nature of nanoparticles. Furthermore, nanomaterials‐driven immunomodulation might exploited therapeutic purposes, opening new horizons in oncology beyond. In this scenario, we present a critical review state art regarding preclinical evaluation effects most promising metals biomedical applications (gold, silver, copper) system. Because exploiting interactions between inorganic may result game changer management (non)communicable diseases, within encounter need to summarize organize plethora sometimes inconsistent information, analyzing challenges providing expected perspectives. field is still its infancy, our work emphasizes deep understanding influence features metal both cultured cells animal models pivotal safe translation nanotherapeutics clinical practice.
Язык: Английский
Процитировано
0
The European Physical Journal Plus, Год журнала: 2025, Номер 140(4)
Опубликована: Апрель 28, 2025
Язык: Английский
Процитировано
0
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Июнь 7, 2025
Exosomes, as natural intercellular messengers, are gaining prominence delivery vehicles in nanomedicine, offering a superior alternative to conventional synthetic nanoparticles for cancer therapeutics. Unlike lipid, polymer, or metallic nanoparticles, which often face challenges related immunogenicity, targeting precision, and off-tumor toxicity, exosomes can effectively encapsulate diverse range of therapeutic agents while exhibiting low favorable pharmacokinetics, organotropic properties. This review examines recent advancements exosome bioengineering over the past decade. Innovations such microfluidics-based platforms, nanoporation, fusogenic hybrids, genetic engineering have significantly improved loading efficiencies, production scalability, pharmacokinetics exosomes. These facilitate tumor-specific cargo delivery, resulting substantial improvements retention efficacy essential clinical success. Moreover, enhanced biodistribution, targeting, bioavailability-through strategies cell selection, surface modifications, membrane composition alterations, biomaterial integration-suggests promising future an ideal nanomedicine platform. We also highlight translational impact these through emerging trials. Additionally, we outline framework translation that focuses on: sourcing, precision methodologies, route-specific optimization. In summary, this emphasizes potential overcome pharmacokinetic safety long impeded oncology drug development, thus enabling safer more effective treatments.
Язык: Английский
Процитировано
0