Physics in Medicine and Biology,
Год журнала:
2024,
Номер
69(14), С. 14TR02 - 14TR02
Опубликована: Июль 3, 2024
Functional
nanomaterials
have
emerged
as
versatile
nanotransducers
for
wireless
neural
modulation
because
of
their
minimal
invasion
and
high
spatiotemporal
resolution.
The
can
convert
external
excitation
sources
(e.g.
NIR
light,
x-rays,
magnetic
fields)
to
visible
light
(or
local
heat)
activate
optogenetic
opsins
thermosensitive
ion
channels
neuromodulation.
present
review
provides
insights
into
the
fundamentals
mostly
used
functional
in
neuromodulation
including
upconversion
nanoparticles,
nanoscintillators,
nanoparticles.
We
further
discussed
recent
developments
design
strategies
with
enhanced
energy
conversion
performance
that
greatly
expanded
field
summarized
applications
nanomaterials-mediated
techniques,
exciting/silencing
neurons,
modulating
brain
activity,
controlling
motor
behaviors,
regulating
peripheral
organ
function
mice.
Finally,
we
some
key
considerations
nanotransducer-mediated
along
current
challenges
future
directions.
Nanomaterials,
Год журнала:
2024,
Номер
14(13), С. 1085 - 1085
Опубликована: Июнь 25, 2024
Carbon-based
nanomaterials,
such
as
carbon
quantum
dots
(CQDs)
and
2D
nanosheets
(graphene,
graphene
oxide,
graphdiyne),
have
shown
remarkable
potential
in
various
biological
applications.
CQDs
offer
tunable
photoluminescence
excellent
biocompatibility,
making
them
suitable
for
bioimaging,
drug
delivery,
biosensing,
photodynamic
therapy.
Additionally,
CQDs'
unique
properties
enable
bioimaging-guided
therapy
targeted
imaging
of
biomolecules.
On
the
other
hand,
exhibit
exceptional
physicochemical
attributes,
with
excelling
biosensing
also
delivery
antimicrobial
applications,
graphdiyne
tissue
engineering.
Their
properties,
porosity
high
surface
area,
contribute
to
controlled
release
enhanced
regeneration.
However,
challenges,
including
long-term
biocompatibility
large-scale
synthesis,
necessitate
further
research.
Potential
future
directions
encompass
theranostics,
immunomodulation,
neural
interfaces,
bioelectronic
medicine,
expanding
bioimaging
capabilities.
In
summary,
both
hold
promise
revolutionize
biomedical
sciences,
offering
innovative
solutions
improved
therapies
diverse
contexts.
Addressing
current
challenges
will
unlock
their
full
can
shape
medicine
biotechnology.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Март 6, 2024
Abstract
Transmembrane
channels
play
a
vital
role
in
regulating
the
permeation
process,
and
have
inspired
recent
development
of
biomimetic
channels.
Herein,
we
report
class
artificial
nanochannels
based
on
DNAzyme-functionalized
glass
nanopipettes
to
realize
delicate
control
channel
permeability,
whereby
surface
wettability
charge
can
be
tuned
by
metal
ions
DNAzyme-substrates,
allowing
reversible
conversion
between
different
permeability
states.
We
demonstrate
that
reversibly
switched
four
states
showing
distinct
various
functional
molecules.
By
embedding
into
plasma
membrane
single
living
cells,
achieve
selective
transport
dye
molecules
across
cell
membrane.
Finally,
advanced
functions
including
gene
silencing
miR-21
cancer
cells
Ca
2+
PC-12
cells.
In
this
work,
provide
versatile
tool
for
design
rectifying
with
on-demand
functions.
Frontiers in Molecular Biosciences,
Год журнала:
2023,
Номер
10
Опубликована: Окт. 12, 2023
Fibrosis
could
happen
in
every
organ,
leading
to
organic
malfunction
and
even
organ
failure,
which
poses
a
serious
threat
global
health.
Early
treatment
of
fibrosis
has
been
reported
be
the
turning
point,
therefore,
exploring
potential
correlates
pathogenesis
how
reverse
become
pressing
issue.
As
mechanism-sensitive
cationic
calcium
channel,
Piezo1
turns
on
response
changes
lipid
bilayer
plasma
membrane.
exerts
multiple
biological
roles,
including
inhibition
inflammation,
cytoskeletal
stabilization,
epithelial-mesenchymal
transition,
stromal
stiffness,
immune
cell
mechanotransduction,
interestingly
enough.
These
processes
are
closely
associated
with
development
fibrotic
diseases.
Recent
studies
have
shown
that
deletion
or
knockdown
attenuates
onset
fibrosis.
Therefore,
this
paper
we
comprehensively
describe
biology
gene,
focusing
its
relevance
pulmonary
fibrosis,
renal
pancreatic
cardiac
diseases,
except
for
role
drugs
(agonists),
increased
intracellular
mechanical
stress
using
gene
alleviating
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 29, 2025
Cancer
cells
possess
distinct
bioelectrical
properties,
yet
therapies
leveraging
these
characteristics
remain
underexplored.
Herein,
we
introduce
an
innovative
nanobioelectronic
system
combining
a
piezoelectric
barium
titanate
nanoparticle
core
with
conducting
poly(3,4-ethylenedioxythiophene)
shell
(BTO@PEDOT
NPs),
designed
to
modulate
cancer
cell
bioelectricity
through
noninvasive,
wireless
stimulation.
Our
hypothesis
is
that
acting
as
nanoantennas,
BTO@PEDOT
NPs
convert
mechanical
inputs
provided
by
ultrasound
(US)
into
electrical
signals,
capable
of
interfering
the
bioelectronic
circuitry
two
human
breast
lines,
MCF-7
and
MDA-MB-231.
Upon
US
stimulation,
viability
MDA-MB-231
treated
200
μg
mL-1
reduced
significantly
31%
24%,
respectively,
while
healthy
mammary
fibroblasts
(HMF)
were
unaffected
treatment.
Subsequent
assays
shed
light
on
how
this
approach
could
interact
cell's
mechanisms,
namely,
increasing
intracellular
reactive
oxygen
species
(ROS)
calcium
concentrations.
Furthermore,
was
able
polarize
membranes,
halting
their
cycle
potentially
harnessing
tumorigenic
characteristics.
These
findings
underscore
crucial
role
in
progression
highlight
potential
systems
emerging
promising
strategy
for
intervention.
Nanomaterials
have
been
vastly
used
in
daily
life.
However,
owing
to
their
unique
properties,
nanomaterials
also
show
potential
side
effects.
Among
the
various
organs
affected
by
nanomaterials,
circulatory
system
stands
out
as
particularly
vulnerable,
drawing
additional
attention
its
cardiac
toxicity.
To
address
cardiovascular
nanotoxicity
and
further
promote
safe
use
of
nanotechnology,
a
comprehensive
review
cardiotoxicity
induced
is
provided.
The
begins
identifying
current
research
trends
hotspots
this
field
via
bibliometric
analysis.
Subsequently,
based
on
objectively
obtained
hotspots,
mechanism
nanotoxicity,
including
exposure
route,
membrane
injury,
ion
disturbance,
oxidative
stress,
inflammation,
cell
death,
reviewed
discussed.
Finally,
strategies
for
mitigation
are
proposed.
objective
assist
readers
understanding
facilitate
application
human
health.
