Current Nanomedicine, Год журнала: 2023, Номер 13(2), С. 71 - 74
Опубликована: Июль 1, 2023
Язык: Английский
International Journal of Molecular Medicine, Год журнала: 2023, Номер 52(5)
Опубликована: Сен. 22, 2023
Ectodermal mesenchymal stem cells (EMSCs) are harvested from the cell niche (nasal mucosa) with high therapeutic potential. To best of our knowledge, however, anti‑inflammatory properties these neural crest‑derived EMSCs have been rarely reported. The present study aimed to explore effects aerosolized EMSC‑Secretome (EMSC‑Sec) and clarify underlying mechanisms in treating acute lung injury (ALI). were isolated by adherent method identified immunofluorescence staining. EMSC‑Sec was collected evaluated using western blotting, BCA ELISA tests. Then, mouse epithelial (MLE‑12) used mimic inflammatory stimulation lipopolysaccharide (LPS). After developing an ALI model through intraperitoneal injection LPS, mice treated spray. each group underwent observation measurement preliminarily assess extent damage. H&E staining, immunohistochemical western‑blotting utilized further access impacts EMSC‑Sec. results showed that had great potential highly successful vitro vivo. mitigated LPS‑induced low inflation mild could regulate inflammation via NF‑κB(p50/p65)/NLRP3 pathway. Overall, demonstrated regulated inflammation, hoping provide a novel strategy for treatment.
Язык: Английский
Процитировано
4
Internal Medicine, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Asthma and chronic obstructive pulmonary disease (COPD) have long been debated regarding their similarities differences in clinical presentation pathology. There has also a discussion about how common therapeutics should be used differently for each disease. Traditionally, "one size fits all" stepwise treatment chosen based on the severity of case after categorizing diseases, such as asthma or COPD. However, recently, need precise approach individual patients beyond category emphasized, especially severe cases. To achieve personalized therapy, it become necessary to focus phenotypes underlying causal molecular mechanisms (endotypes) identify key therapeutic targets, which are called treatable traits. This review discusses evidence importance identifying traits strategies broader perspective airway rather than diseases
Язык: Английский
Процитировано
0
Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 208, С. 115273 - 115273
Опубликована: Март 5, 2024
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Авг. 12, 2024
Current needle-based vaccination for respiratory viruses is ineffective at producing sufficient, long-lasting local immunity in the elderly. Direct pulmonary delivery to resident immune cells can create long-term mucosal responses. However, criteria drug vehicle design rules that overcome age-specific changes cell functions have yet be established.
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2024, Номер 1(3), С. 100038 - 100038
Опубликована: Ноя. 5, 2024
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
International Journal of COPD, Год журнала: 2024, Номер Volume 19, С. 2689 - 2703
Опубликована: Дек. 1, 2024
Immune checkpoint inhibitors are a standard treatment option for many patients with cancer and most frequently used to treat lung cancer. Chronic obstructive pulmonary disease (COPD) is the common comorbidity of As cancer-specific survival continues increase modern treatments, it critical optimize comorbidities improve overall survival. This literature review aimed summarize current research on impact COPD upon immunotherapy outcomes.
Язык: Английский
Процитировано
0
Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер unknown, С. 136022 - 136022
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0
Current Nanomedicine, Год журнала: 2023, Номер 13(2), С. 71 - 74
Опубликована: Июль 1, 2023
Язык: Английский
Процитировано
0