Particulate Vaccine Dispersions Emerge as a Novel Carrier for Deep Pulmonary Immunization DOI
Dilpreet Singh, Prashant Tiwari, Sanjay Nagdev

et al.

Current Nanomedicine, Journal Year: 2023, Volume and Issue: 13(2), P. 71 - 74

Published: July 1, 2023

Language: Английский

Secretome of EMSCs neutralizes LPS‑induced acute lung injury via aerosol administration DOI Creative Commons

Jianing Tan,

Ziliang Zhuo,

Xiuyu Wang

et al.

International Journal of Molecular Medicine, Journal Year: 2023, Volume and Issue: 52(5)

Published: Sept. 22, 2023

Ectodermal mesenchymal stem cells (EMSCs) are harvested from the cell niche (nasal mucosa) with high therapeutic potential. To best of our knowledge, however, anti‑inflammatory properties these neural crest‑derived EMSCs have been rarely reported. The present study aimed to explore effects aerosolized EMSC‑Secretome (EMSC‑Sec) and clarify underlying mechanisms in treating acute lung injury (ALI). were isolated by adherent method identified immunofluorescence staining. EMSC‑Sec was collected evaluated using western blotting, BCA ELISA tests. Then, mouse epithelial (MLE‑12) used mimic inflammatory stimulation lipopolysaccharide (LPS). After developing an ALI model through intraperitoneal injection LPS, mice treated spray. each group underwent observation measurement preliminarily assess extent damage. H&E staining, immunohistochemical western‑blotting utilized further access impacts EMSC‑Sec. results showed that had great potential highly successful vitro vivo. mitigated LPS‑induced low inflation mild could regulate inflammation via NF‑κB(p50/p65)/NLRP3 pathway. Overall, demonstrated regulated inflammation, hoping provide a novel strategy for treatment.

Language: Английский

Citations

4
Clinical Benefits of Targeting Treatable Traits in Asthma and Chronic Obstructive Pulmonary Disease DOI Open Access
Yuko Morishima,

Nobuyuki Hizawa

Internal Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Asthma and chronic obstructive pulmonary disease (COPD) have long been debated regarding their similarities differences in clinical presentation pathology. There has also a discussion about how common therapeutics should be used differently for each disease. Traditionally, "one size fits all" stepwise treatment chosen based on the severity of case after categorizing diseases, such as asthma or COPD. However, recently, need precise approach individual patients beyond category emphasized, especially severe cases. To achieve personalized therapy, it become necessary to focus phenotypes underlying causal molecular mechanisms (endotypes) identify key therapeutic targets, which are called treatable traits. This review discusses evidence importance identifying traits strategies broader perspective airway rather than diseases

Language: Английский

Citations

0
Age-dependent changes in phagocytic activity: in vivo response of mouse pulmonary antigen presenting cells to direct lung delivery of charged PEGDA nanoparticles DOI Creative Commons
Emma R. Sudduth, Aida López Ruiz, Michael Trautmann-Rodriguez

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 12, 2024

Current needle-based vaccination for respiratory viruses is ineffective at producing sufficient, long-lasting local immunity in the elderly. Direct pulmonary delivery to resident immune cells can create long-term mucosal responses. However, criteria drug vehicle design rules that overcome age-specific changes cell functions have yet be established.

Language: Английский

Citations

0
Modulating immune responses for enhanced cell therapies: The dual role of multi-scale biomaterials DOI Creative Commons
Jianan Zeng, Yuhong Jin,

Yanxiao Ao

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(3), P. 100038 - 100038

Published: Nov. 5, 2024

Language: Английский

Citations

0
Interactive Response Analysis of Transportation and Deposition of Engineered Aerosol Particle in Airway DOI

Yiyang Guo,

Xiao Han, Lei Zhang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Interactive response analysis of transportation and deposition of engineered aerosol particle in airway DOI

Yiyang Guo,

Han Xiao, Lei Zhang

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 136022 - 136022

Published: Dec. 1, 2024

Language: Английский

Citations

0
Emerging Voices in Drug Delivery – Breaking Barriers (Issue 1) DOI
Juliane Nguyen, Shawn C. Owen

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 208, P. 115273 - 115273

Published: March 5, 2024

Language: Английский

Citations

0
COPD and Immune Checkpoint Inhibitors for Cancer: A Literature Review DOI Creative Commons
Thomas Lycan, D. Norton, Jill Ohar

et al.

International Journal of COPD, Journal Year: 2024, Volume and Issue: Volume 19, P. 2689 - 2703

Published: Dec. 1, 2024

Immune checkpoint inhibitors are a standard treatment option for many patients with cancer and most frequently used to treat lung cancer. Chronic obstructive pulmonary disease (COPD) is the common comorbidity of As cancer-specific survival continues increase modern treatments, it critical optimize comorbidities improve overall survival. This literature review aimed summarize current research on impact COPD upon immunotherapy outcomes.

Language: Английский

Citations

0
Particulate Vaccine Dispersions Emerge as a Novel Carrier for Deep Pulmonary Immunization DOI
Dilpreet Singh, Prashant Tiwari, Sanjay Nagdev

et al.

Current Nanomedicine, Journal Year: 2023, Volume and Issue: 13(2), P. 71 - 74

Published: July 1, 2023

Language: Английский

Citations

0