Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 199, С. 114991 - 114991
Опубликована: Июль 4, 2023
Язык: Английский
Cancers, Год журнала: 2025, Номер 17(5), С. 878 - 878
Опубликована: Март 4, 2025
Nanotechnology, particularly quantum dots (QDs), has ushered in a transformative era the pharmaceutical and medical industries, offering notable opportunities for nanoscale advancements. These particles, known their exceptional optical properties confinement, have emerged as indispensable tools cancer drug delivery bioimaging. This review delves into various conjugation techniques with QDs, including covalent linking, non-covalent conjugation, click chemistry, disulfide linkage, pH-sensitive linkage. Each method provides distinct advantages, such enhanced stability, reversibility, specificity, controlled release. Moreover, QDs demonstrated significant promise oncology by efficiently delivering drugs to cancerous tissues while minimising systemic toxicity. Investigations applications different cancers, blood, brain, cervical, breast etc., reveal efficacy targeted delivery, real-time imaging, improved therapeutic outcomes. However, challenges potential toxicity, pharmacokinetics, targeting specificity must be addressed fully harness benefits of therapy. Future research should focus on developing biocompatible optimising techniques, elucidating safety profiles long-term effects biological systems. Overall, represent promising frontier treatment, multifaceted capabilities that hold outcomes reduced side across cancers.
Язык: Английский
Процитировано
2
Advanced Functional Materials, Год журнала: 2023, Номер 34(7)
Опубликована: Ноя. 5, 2023
Abstract Cancer immunotherapy has the potential to revolutionize treatment of malignant tumors, but its effectiveness is limited by low immune response rate and immune‐related adverse events. Pyroptosis, as an inflammatory programmed cell death type, triggers strong acute antitumor immunity, converting “cold” tumors “hot”. Particularly, biomaterials loading pyroptosis inducers targeting tumor microenvironment engineer pyroptosis, have achieved great progress in recent years. Herein, design strategy, mechanism pathway, role induce cancer are comprehensively reviewed. The present review focuses on application biomaterials‐induced immunotherapy, including nanogel, polymer prodrug, nanovesicle, mesoporous material. Additionally, synthesis a series stimuli‐responsive nanoplatforms, glutathione‐responsive, pH‐responsive, reactive oxygen species‐responsive, enzyme‐mimicking catalytic performance, described. Meanwhile, it augments multiple processes uptake, antigen presentation, T‐cell activation, expansion. Finally, perspectives pyroptosis‐mediated inflammation break through vascular basement membrane barrier achieving efficient volcanic penetration discussed. Artificial intelligence, multi‐omics analysis, anthropogenic animal models organoids presented, aiming provide guidance assistance for constructing effective controllable pyroptosis‐engineered improving immunotherapy.
Язык: Английский
Процитировано
24
Nano-Structures & Nano-Objects, Год журнала: 2024, Номер 39, С. 101217 - 101217
Опубликована: Июнь 17, 2024
Язык: Английский
Процитировано
6
Gels, Год журнала: 2023, Номер 9(8), С. 669 - 669
Опубликована: Авг. 18, 2023
Nanocomposite polymeric gels infused with fluorescent nanoparticles have surfaced as a propitious category of substances for biomedical purposes owing to their exceptional characteristics. The aforementioned materials possess blend desirable characteristics, including biocompatibility, biodegradability, drug encapsulation, controlled release capabilities, and optical properties that are conducive imaging tracking. This paper presents comprehensive analysis the synthesis characterization fluorescent-nanoparticle-impregnated nanocomposite gels, well applications, such delivery, imaging, tissue engineering. In this discourse, we deliberate upon merits obstacles linked these substances, encompassing scalability. present study aims provide an overall evaluation potential applications. Additionally, emerging trends future directions research in area highlighted.
Язык: Английский
Процитировано
11
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 101, С. 106146 - 106146
Опубликована: Сен. 3, 2024
Язык: Английский
Процитировано
4
Small, Год журнала: 2025, Номер 21(9)
Опубликована: Янв. 19, 2025
Abstract Rare genetic diseases (RGDs) affect a small percentage of the global population but collectively have substantial impact due to their diverse manifestations. Although precise reasons behind these remain unclear, roughly 80% cases are genetically linked. Recent efforts focus on understanding pathology and developing new diagnostic therapeutic approaches for RGDs. However, there persists gap between fundamental research clinical approaches, where advancements in nanotechnology offer promising improvements. In this context, nanosized light‐emitting quantum dots (QDs), ranging from 2–10 nm, materials applications. Their size‐tunable light emission, high yield, photostability allow tracking cargo. Additionally, QDs can be functionalized with agents, antibodies, or peptides target specific cellular pathways, enhancing treatment efficacy while minimizing side effects. By combining capabilities single platform, thus versatile powerful approach tackle rare disorders. Despite several reviews various applications QDs, utilization domain RGDs is not well documented. This review highlight QDs’ potential diagnosing treating certain addresses challenges limiting application.
Язык: Английский
Процитировано
0
Smart Materials in Medicine, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Язык: Английский
Процитировано
0
Nanoscale, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy characterized by limited treatment options and poor prognosis. Nanoparticle-based drug delivery systems have emerged as a promising strategy to enhance cancer therapy efficacy improving targeting, reducing toxicity, enabling multifunctional applications. This review highlights some key types of nanoparticles, including liposomes, polymeric metallic dendrimers, quantum dots, which could effectively improve the various drugs used in chemotherapy, radiotherapy, immunotherapy, offering more precise effective options. With ability stability overcome biological barriers, nanoparticle-based represent transformative for ESCC treatment. Despite challenges, such biocompatibility scalability, future holds great promise, particularly development personalized nanomedicine novel therapeutic approaches targeting tumor microenvironment. ongoing advancements, hold immense potential revolutionize patient outcomes.
Язык: Английский
Процитировано
0
Next Nanotechnology, Год журнала: 2025, Номер 8, С. 100158 - 100158
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0