Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
15(2), С. 852 - 875
Опубликована: Ноя. 23, 2024
Cancer
immunotherapy
is
currently
a
very
promising
therapeutic
strategy
for
treating
tumors.
However,
its
effectiveness
restricted
by
insufficient
antigenicity
and
an
immunosuppressive
tumor
microenvironment
(ITME).
Pyroptosis,
unique
form
of
programmed
cell
death
(PCD),
causes
cells
to
swell
rupture,
releasing
pro-inflammatory
factors
that
can
enhance
immunogenicity
remodel
the
ITME.
Nanomaterials,
with
their
distinct
advantages
different
techniques,
are
increasingly
popular,
nanomaterial-based
delivery
systems
demonstrate
significant
potential
potentiate,
enable,
augment
pyroptosis.
This
review
summarizes
discusses
emerging
field
nanomaterials-induced
pyroptosis,
focusing
on
mechanisms
pyroptosis
pathways
strategies
activate
or
specific
Additionally,
we
provide
perspectives
development
this
field,
aiming
accelerate
further
clinical
transition.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
Gasdermin
(GSDM)-mediated
pyroptosis
involves
the
induction
of
mitochondrial
damage
and
subsequent
release
DNA
(mtDNA),
which
is
anticipated
to
activate
cGAS-STING
pathway,
thereby
augmenting
antitumor
immune
response.
However,
challenges
lie
in
effectively
triggering
cancer
cells
subsequently
enhancing
activation
with
specificity.
Herein,
we
developed
intelligent
self-cascaded
pyroptosis-STING
initiators
cobalt
fluoride
(CoF2)
nanocatalysts
for
catalytic
metalloimmunotherapy.
CoF2
a
semiconductor
structure
enzyme-like
activity
generated
substantial
amount
reactive
oxygen
species
(ROS)
under
stimulation
by
endogenous
H2O2
exogenous
ultrasound.
Importantly,
discovered
that
Co-based
nanomaterials
themselves
induce
cells.
Therefore,
initially
acted
as
inducers,
caspase-1/GSDMD-dependent
via
Co2+
ROS,
leading
mtDNA
release.
Subsequently,
were
further
utilized
STING
agonists
specifically
capable
detecting
pathway.
These
cascade
events
triggered
robust
response,
modulating
immunosuppressive
tumor
microenvironment
into
an
immune-supportive
state,
providing
favorable
support
therapy.
This
innovative
strategy
not
only
significantly
impeded
growth
primary
but
also
elicited
response
augment
efficacy
checkpoint
inhibitors
preventing
distant
progression.
Overall,
this
study
proposed
self-cascade
activating
amplifying
pathway
specificity
mediated
pyroptosis,
representing
valuable
avenue
future
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
The
designability
and
high
reactivity
of
nanotechnology
provide
strategies
for
antitumor
therapy
by
regulating
the
redox
state
in
tumor
cells.
Here,
we
synthesize
a
kind
vanadium
dioxide
nanoparticle
encapsulated
bovine
serum
albumin
containing
disulfide
bonds
(VSB
NPs)
photothermal-enhanced
ferroptosis
pyroptosis
effects.
Mechanism
studies
show
that
can
effectively
consume
overexpressed
glutathione
(GSH)
microenvironment,
leading
to
decrease
peroxidase
4
(GPX4)
activity.
Simultaneously,
tetravalent
induce
catalytic
reaction
H2O2,
producing
plenty
toxic
hydroxyl
radicals
(·OH)
singlet
oxygen
(1O2),
cell
ferroptosis.
In
addition,
consumption
also
lead
degradation
nanoparticles
into
high-valent
vanadates,
activating
thermal
protein
domain-associated
3
(NLRP3)
inflammasomes
causing
pyroptosis.
It
is
worth
mentioning
VSB
NPs
not
only
ablate
cells
under
near-infrared
light
irradiation
but
further
disrupt
homeostasis
thereby
enhancing
induced
biodegradable
vanadium-based
nanomaterials.
This
strategy,
based
on
biological
effects
regulate
cells,
provides
possibilities
cancer
treatment.
