eXPRESS Polymer Letters,
Год журнала:
2023,
Номер
18(2), С. 160 - 192
Опубликована: Дек. 6, 2023
Polymer-based
hydrogels
are
hydrophilic
polymer
networks
with
a
remarkable
capacity
to
absorb
substantial
amounts
of
water
and
biological
fluids,
rendering
them
highly
attractive
for
drug
delivery
applications.The
COVID-19
pandemic
has
acted
as
catalyst
research
innovation
in
the
realm
polymer-based
delivery,
particular
emphasis
on
antiviral
therapeutics,
vaccines,
diagnostics,
precision
respiratory
system.The
distinctive
attributes
hydrogels,
such
their
biocompatibility,
customizable
release
profiles,
ease
functionalization,
establish
versatile
platforms
development
advanced
systems
combat
not
only
but
also
spectrum
other
infectious
diseases.This
study
is
dedicated
scruti-nizing
evaluating
characteristics
employed
treatment
diseases
associated
SARS-CoV-2
virus.Furthermore,
investigation
introduces
novel
classification
system
deployed
SARS-CoV-2-related
diseases.Additionally,
paper
provides
an
up-to-date
evaluation
latest
developed
utilized
dis-eases
linked
virus,
based
conducted
through
recent
months
2023.
Intravitreal
injections
of
antivascular
endothelial
growth
factor
(VEGF)
agents
are
the
primary
method
for
treating
retinal
vein
occlusion
(RVO).
However,
complex
structure
eye
anatomy
presents
ocular
barriers
that
impede
drug
delivery.
Additionally,
these
drugs
only
manage
complications
associated
with
RVO
and
fail
to
address
underlying
cause
vessel
occlusions.
Here,
we
describe
a
utilizes
functionalized
magnetically
driven
nanorobots
overcome
treat
RVO.
These
developed
using
hybrid
biomembrane
combines
stem
cell
membranes
liposome-derived
membranes,
enveloping
perfluorohexane,
iron
oxide
nanoparticles,
l-arginine.
After
intravitreal
injection,
can
move
directionally
through
penetrate
vitreous
body
reach
retina,
by
an
external
magnetic
field.
Subsequently,
actively
target
inflammation
sites
at
occluded
vessels
due
presence
membranes.
In
rat
model
RVO,
enhanced
targeting
accumulation
in
ischemic
were
demonstrated
following
injections.
Furthermore,
application
ultrasound
triggers
release
l-arginine
site
occlusion,
stimulating
production
nitric
oxide,
which
promotes
vasodilation
restores
blood
flow,
thereby
achieving
excellent
therapeutic
efficacy
We
believe
methods
hold
significant
promise
overcoming
challenges
delivery
effectively
clinical
applications.
Molecules,
Год журнала:
2025,
Номер
30(6), С. 1210 - 1210
Опубликована: Март 8, 2025
Rare
earth
metal
nanoparticles,
some
of
which
are
already
widely
used
in
medicine,
growing
interest
the
modern
scientific
community.
One
promising
rare
metals
for
biomedical
applications
is
cerium,
specifically
its
oxide
form,
characterized
by
a
higher
level
stability
and
safety.
According
to
number
studies,
cerium
dioxide
has
wide
range
biological
effects
(regenerative,
antimicrobial,
antioxidant,
antitumor),
justifies
potential
application
medicine.
However,
these
their
intensity
vary
significantly
across
studies.
Since
was
it
can
be
assumed
that
not
only
chemical
formula
important,
but
also
physicochemical
parameters
nanoparticles
obtained,
consequently
methods
synthesis
modification
with
use
excipients.
In
this
review,
we
considered
possibilities
using
excipients
(polyacrylate,
polyvinylpyrrolidone,
dextran,
hyaluronic
acid,
chitosan,
polycarboxylic
acids,
lecithin,
phosphatidylcholine)
context
preserving
properties,
as
well
degree
study
combinations
from
point
view
prospect
creating
drugs
based
on
applications.
Abstract
In
recent
years,
nanomaterials
have
demonstrated
broad
prospects
in
the
diagnosis
and
treatment
of
retinal
diseases
due
to
their
unique
physicochemical
properties,
such
as
small‐size
effects,
high
biocompatibility,
functional
surfaces.
Retinal
are
often
accompanied
by
complex
pathological
microenvironments,
where
conventional
diagnostic
therapeutic
approaches
face
challenges
low
drug
delivery
efficiency,
risks
associated
with
invasive
procedures,
difficulties
real‐time
monitoring.
Nanomaterials
hold
promise
addressing
these
limitations
traditional
therapies,
thereby
improving
precision
efficacy.
The
applications
diagnostics
summarized,
they
enable
high‐resolution
imaging
carrying
fluorescent
probes
or
contrast
agents
act
biosensors
sensitively
detect
disease‐related
biomarkers,
facilitating
early
dynamic
therapeutics,
functionalized
nanocarriers
can
precisely
deliver
drugs,
genes,
antioxidant
molecules
target
cells,
significantly
enhancing
outcomes
while
reducing
systemic
toxicity.
Additionally,
nanofiber
materials
possess
properties
that
make
them
particularly
suitable
for
regeneration
tissue
engineering.
By
loading
neurotrophic
factors
into
scaffolds,
regenerative
effects
be
amplified,
promoting
repair
neurons.
Despite
immense
potential,
clinical
translation
still
requires
long‐term
biosafety,
scalable
manufacturing
processes,
optimization
targeting
efficiency.
Clinical ophthalmology,
Год журнала:
2025,
Номер
Volume 19, С. 1565 - 1582
Опубликована: Май 1, 2025
Vascular
Retinopathy
(VR),
such
as
diabetic
retinopathy,
pose
significant
challenges
to
vision
and
overall
health.
Traditional
treatment
methods
often
face
limitations
in
efficacy
delivery.
retinopathy
is
a
common
potentially
blinding
group
of
eye
diseases
with
core
pathologic
mechanisms
involving
vascular
injury,
ischemia,
exudation,
neovascularization.
Clinical
management
relies
heavily
on
etiologic
control
(eg,
diabetes,
hypertension),
anti-VEGF
therapy,
laser
surgical
intervention.
Recent
advancements
nanotechnology
have
led
the
development
innovative
nanoparticle
drug
carriers,
which
offer
promising
solutions
for
targeted
sustained
delivery
retinal
environment.
This
review
explores
application
both
conventional
novel
carriers
treating
VR.
We
discuss
various
types
nanoparticles,
including
liposomes,
polymeric
metal-based
highlighting
their
unique
properties,
action,
therapeutic
benefits.
Finally,
we
provide
insights
into
future
perspectives
nanoparticle-based
therapies
disorders,
emphasizing
potential
improved
patient
outcomes
need
further
research
optimize
these
advanced
systems.
