Novel polymer-based hydrogels of recent research in drug delivery for disease treatment related to SARS-CoV-2 virus DOI Creative Commons
Hoc Thang Nguyen, Nguyen Van Phuc,

Tran Thi Tu Nhi

et al.

eXPRESS Polymer Letters, Journal Year: 2023, Volume and Issue: 18(2), P. 160 - 192

Published: Dec. 6, 2023

Polymer-based hydrogels are hydrophilic polymer networks with a remarkable capacity to absorb substantial amounts of water and biological fluids, rendering them highly attractive for drug delivery applications.The COVID-19 pandemic has acted as catalyst research innovation in the realm polymer-based delivery, particular emphasis on antiviral therapeutics, vaccines, diagnostics, precision respiratory system.The distinctive attributes hydrogels, such their biocompatibility, customizable release profiles, ease functionalization, establish versatile platforms development advanced systems combat not only but also spectrum other infectious diseases.This study is dedicated scruti-nizing evaluating characteristics employed treatment diseases associated SARS-CoV-2 virus.Furthermore, investigation introduces novel classification system deployed SARS-CoV-2-related diseases.Additionally, paper provides an up-to-date evaluation latest developed utilized dis-eases linked virus, based conducted through recent months 2023.

Language: Английский

Co-delivery of antioxidants and siRNA-VEGF: promising treatment for age-related macular degeneration DOI
Marina França Dias, Estael Luzia Coelho da Cruz-Cazarim, Frederico Pittella

et al.

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

Citations

1
Hybrid Biomembrane-Functionalized Nanorobots Penetrate the Vitreous Body of the Eye for the Treatment of Retinal Vein Occlusion DOI
Siyu Wang, Xinmeng Chen, Yewei Liu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Intravitreal injections of antivascular endothelial growth factor (VEGF) agents are the primary method for treating retinal vein occlusion (RVO). However, complex structure eye anatomy presents ocular barriers that impede drug delivery. Additionally, these drugs only manage complications associated with RVO and fail to address underlying cause vessel occlusions. Here, we describe a utilizes functionalized magnetically driven nanorobots overcome treat RVO. These developed using hybrid biomembrane combines stem cell membranes liposome-derived membranes, enveloping perfluorohexane, iron oxide nanoparticles, l-arginine. After intravitreal injection, can move directionally through penetrate vitreous body reach retina, by an external magnetic field. Subsequently, actively target inflammation sites at occluded vessels due presence membranes. In rat model RVO, enhanced targeting accumulation in ischemic were demonstrated following injections. Furthermore, application ultrasound triggers release l-arginine site occlusion, stimulating production nitric oxide, which promotes vasodilation restores blood flow, thereby achieving excellent therapeutic efficacy We believe methods hold significant promise overcoming challenges delivery effectively clinical applications.

Language: Английский

Citations

1
Lipoplexes’ Structure, Preparation, and Role in Managing Different Diseases DOI
Sally A. El‐Zahaby, Lovepreet Kaur, Ankur Sharma

et al.

AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(5)

Published: June 7, 2024

Language: Английский

Citations

5
Liposomes and Niosomes: New trends and applications in the delivery of bioactive agents for cancer therapy DOI
Helena de Almeida Cerqueira Kodel,

Paria Alizadeh,

Samad Nejad Ebrahimi

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124994 - 124994

Published: Nov. 1, 2024

Language: Английский

Citations

4
Preparation and characterization of multilayered microcapsules of Lactobacillus rhamnosus encapsulated with sodium alginate, hyaluronic acid and carrageenan and their protective effects on the retina DOI
Xiaodong Wang, Wenqing Lv, Chunxue Zhai

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141104 - 141104

Published: Feb. 1, 2025

Language: Английский

Citations

0
Excipients for Cerium Dioxide Nanoparticle Stabilization in the Perspective of Biomedical Applications DOI Creative Commons

Svetlana A. Titova,

Maria Petrovna Kruglova, Stupin Va

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1210 - 1210

Published: March 8, 2025

Rare earth metal nanoparticles, some of which are already widely used in medicine, growing interest the modern scientific community. One promising rare metals for biomedical applications is cerium, specifically its oxide form, characterized by a higher level stability and safety. According to number studies, cerium dioxide has wide range biological effects (regenerative, antimicrobial, antioxidant, antitumor), justifies potential application medicine. However, these their intensity vary significantly across studies. Since was it can be assumed that not only chemical formula important, but also physicochemical parameters nanoparticles obtained, consequently methods synthesis modification with use excipients. In this review, we considered possibilities using excipients (polyacrylate, polyvinylpyrrolidone, dextran, hyaluronic acid, chitosan, polycarboxylic acids, lecithin, phosphatidylcholine) context preserving properties, as well degree study combinations from point view prospect creating drugs based on applications.

Language: Английский

Citations

0
LNP-encapsulated miRNA29b for Corneal Repair: A Novel Approach to Combat Fibrosis DOI Creative Commons

Dongyan Li,

Jing Ji,

X.Y. Li

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101695 - 101695

Published: March 1, 2025

Language: Английский

Citations

0
Nano lipid-drug conjugates for the treatment of Alzheimer’s disease DOI
Subhajit Mandal, Malay K. Das

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 237 - 291

Published: Jan. 1, 2025

Language: Английский

Citations

0
Application of Nanomaterials in the Diagnosis and Treatment of Retinal Diseases DOI

Yufei Yao,

Qiannan Cao,

Huapan Fang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract In recent years, nanomaterials have demonstrated broad prospects in the diagnosis and treatment of retinal diseases due to their unique physicochemical properties, such as small‐size effects, high biocompatibility, functional surfaces. Retinal are often accompanied by complex pathological microenvironments, where conventional diagnostic therapeutic approaches face challenges low drug delivery efficiency, risks associated with invasive procedures, difficulties real‐time monitoring. Nanomaterials hold promise addressing these limitations traditional therapies, thereby improving precision efficacy. The applications diagnostics summarized, they enable high‐resolution imaging carrying fluorescent probes or contrast agents act biosensors sensitively detect disease‐related biomarkers, facilitating early dynamic therapeutics, functionalized nanocarriers can precisely deliver drugs, genes, antioxidant molecules target cells, significantly enhancing outcomes while reducing systemic toxicity. Additionally, nanofiber materials possess properties that make them particularly suitable for regeneration tissue engineering. By loading neurotrophic factors into scaffolds, regenerative effects be amplified, promoting repair neurons. Despite immense potential, clinical translation still requires long‐term biosafety, scalable manufacturing processes, optimization targeting efficiency.

Language: Английский

Citations

0
Revolutionizing Retinal Therapy: The Role of Nanoparticle Drug Carriers in Managing Vascular Retinal Disorders DOI Creative Commons
Huihui Lu, Na He, Lina Zhang

et al.

Clinical ophthalmology, Journal Year: 2025, Volume and Issue: Volume 19, P. 1565 - 1582

Published: May 1, 2025

Vascular Retinopathy (VR), such as diabetic retinopathy, pose significant challenges to vision and overall health. Traditional treatment methods often face limitations in efficacy delivery. retinopathy is a common potentially blinding group of eye diseases with core pathologic mechanisms involving vascular injury, ischemia, exudation, neovascularization. Clinical management relies heavily on etiologic control (eg, diabetes, hypertension), anti-VEGF therapy, laser surgical intervention. Recent advancements nanotechnology have led the development innovative nanoparticle drug carriers, which offer promising solutions for targeted sustained delivery retinal environment. This review explores application both conventional novel carriers treating VR. We discuss various types nanoparticles, including liposomes, polymeric metal-based highlighting their unique properties, action, therapeutic benefits. Finally, we provide insights into future perspectives nanoparticle-based therapies disorders, emphasizing potential improved patient outcomes need further research optimize these advanced systems.

Language: Английский

Citations

0