Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Дек. 23, 2024
The
multi-biological
barriers
present
in
the
inflammatory
microenvironment
severely
limit
targeted
aggregation
of
anti-inflammatory
drugs
lesion
area.
However,
conventional
responsive
drug
carriers
inevitably
come
into
contact
with
several
pro-responsive
stimulatory
mediators
simultaneously,
leading
to
premature
release
and
loss
most
therapeutic
effects.
Breaking
through
multi-level
is
essential
improve
enrichment
bioavailability
drugs.
In
this
study,
we
propose
a
novel
two-stage
structural
strategy
build
shielded
cascades
nanocarriers
(FA-PTP@Que)
mediators,
using
cascade
structures
cross
multiple
environmental
barriers.
structure
FA-PTP@Que
exhibits
ideal
pathological
microenvironmental
response
properties.
has
shown
good
macrophage
regulation
effects
by
efficiently
targeting
macrophages,
scavenging
intracellular
reactive
oxygen
species
(ROS),
down-regulating
secretion
pro-inflammatory
factors.
Significantly,
mice
arthritis
colitis,
enriches
targets
macrophages
at
sites
showing
significant
combines
active
chemotaxis
tissues
effector
cells,
acting
precisely
each
barrier
level
different
microenvironments
responding
overcoming
microenvironment.
This
innovative
can
effectively
break
various
potential
application
other
diseases.
Pharmaceutics,
Год журнала:
2024,
Номер
16(1), С. 151 - 151
Опубликована: Янв. 22, 2024
The
unique
properties
of
ionic
liquids
(ILs),
such
as
structural
tunability,
good
solubility,
chemical/thermal
stability,
favorable
biocompatibility,
and
simplicity
preparation,
have
led
to
a
wide
range
applications
in
the
pharmaceutical
biomedical
fields.
ILs
can
not
only
speed
up
chemical
reaction
process,
improve
yield,
reduce
environmental
pollution
but
also
many
problems
field
medicine,
poor
drug
product
crystal
instability,
biological
activity,
low
delivery
efficiency.
This
paper
presents
systematic
concise
analysis
recent
advancements
further
from
aspects
synthesis,
analysis,
solubilization,
engineering.
Additionally,
it
explores
field,
covering
carriers,
stabilization
proteins,
antimicrobials,
bioactive
liquids.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Abstract
Sigal
peptides
have
garnered
remarkable
efficacy
in
rejuvenating
photoaged
skin
and
delaying
senescence.
Nevertheless,
their
low
solubility
poor
permeability
bring
about
a
formidable
challenge
transdermal
delivery.
To
address
this
challenge,
bioactive
ionic
liquids
(ILs)
synthesized
from
natural
glycyrrhizic
acid
(GA)
oxymatrine
(OMT)
with
eminent
biocompatibility
is
first
prepared.
The
components
ratios
inherent
forming
mechanisms
of
GA‐OMT
(GAO)
are
optimized
by
molecular
dynamics
simulations
density
functional
theory
calculations.
Remarkably,
GAO
can
significantly
improve
the
sparingly
soluble
properties
palmitoyl
pentapeptide‐4
(PAL‐4),
model
peptide
drug.
Subsequently,
self‐assembled
micelles
loading
PAL‐4
(GAO/PAL‐4‐SM)
fabricated
without
additional
auxiliary
materials.
permeation
subcutaneous
retention
promoted
10wt.%
GAO‐SM.
Moreover,
ILs
facilitated
enhancing
its
miscibility
interaction
stratum
corneum
(SC),
offering
pulling
effect
micellar
structures
for
PAL‐4,
as
elucidated
computational
simulations.
In
cellular
animal
photoaging
experiments,
GAO/PAL‐4‐SM
possessed
capabilities
boosting
collagen
hyaluronic
regeneration,
mitigating
inflammation
apoptosis,
accelerating
macrophage
M2
polarization,
thereby
lessening
wrinkles
leveraging
elasticity.
Collectively,
research
innovatively
designed
an
nano‐micellar
delivery
system
to
enhance
anti‐photoaging
signal
peptides.
ACS Nano,
Год журнала:
2024,
Номер
18(4), С. 2564 - 2577
Опубликована: Янв. 16, 2024
Antibiotic
resistance
is
a
major
driver
of
morbidity
and
mortality
worldwide,
necessitating
alternatives.
Due
to
their
mechanism
action,
bacteriophages,
endolysins,
antimicrobial
peptides
(coined
herein
as
nonantibiotic
antibacterials,
NAA)
have
risen
tackle
this
problem
led
paradigms
in
treating
antibiotic-resistant
bacterial
infections.
However,
clinical
applications
remain
challenging
been
seriously
hampered
by
cytotoxicity,
instability,
weak
bioactivity,
low
on-target
bioavailability,
high
pro-inflammatory
responses,
shorter
half-life,
circulatory
properties.
Hence,
transit
preclinical
phases
beyond,
it
has
become
imperative
radically
engineer
these
alternatives
into
innovative
revolutionary
therapeutics
overcome
recalcitrant
This
perspective
highlights
the
promise
agents,
limitations,
promising
designs,
nanotechnology,
delivery
approaches
that
can
be
harnessed
transform
agents.
Finally,
I
provide
an
outlook
on
remaining
challenges
need
tackled
for
widespread
administration.
Journal of Controlled Release,
Год журнала:
2024,
Номер
376, С. 593 - 600
Опубликована: Окт. 25, 2024
Ionic
liquids,
organic
salts
in
a
liquid
state
below
100
°C,
have
traditionally
been
associated
with
industrial
applications.
Recent
research
has
introduced
new
generation
of
ionic
designed
from
biocompatible
ions,
to
enable
applications
drug
delivery.
Here,
I
provide
historical
perspective,
development
status
and
leading
example
salt
Choline
And
Geranic
acid
(CAGE).
Since
its
first
report
2014,
CAGE
opened
multiple
delivery
including
transdermal,
oral,
buccal,
sustained
release,
tissue
ablation,
periodontitis
hand
hygiene,
among
others.
CAGE-based
products
tested
more
than
200
patients
through
Phase
1
2
clinical
studies,
successful
use
study
Atopic
Dermatitis
patients.
became
the
'drug
liquid'
enter
into
trials.
This
article
summarizes
key
fundamental
translational
aspects
as
pertained
Pharmaceutics,
Год журнала:
2024,
Номер
16(3), С. 322 - 322
Опубликована: Фев. 26, 2024
In
this
study,
we
synthesized
a
family
of
novel
ionic
liquids
(ILs)
with
meglumine
(MGM)
as
cations
and
tartaric
acid
(TA),
azelaic
(AA),
geranic
(GA),
capric
(CPA)
anions,
using
pharmaceutical
additives
via
simple
acid-base
neutralization
reactions.
The
successful
synthesis
was
validated
by
attenuated
total
reflection-Fourier
transform
infrared
(ATR-FTIR)
powder
X-ray
diffraction
(PXRD).
Thermal
analysis
differential
scanning
calorimetry
confirmed
the
glass
transition
temperature
MGM-ILs
to
be
within
range
-43.4
°C--13.8
°C.
We
investigated
solubilization
15
drugs
varying
pKa
partition
coefficient
(log
P)
values
these
ILs
performed
comparative
analysis.
Furthermore,
present
MGM-IL
new
skin
permeation
enhancer
for
drug
model
flurbiprofen
(FRP).
that
AA/MGM-IL
improves
FRP
through
hairless
mouse
skin.
Moreover,
enhanced
permeability
affecting
keratin
rather
than
stratum
corneum
lipids,
ATR-FTIR.
To
conclude,
exhibited
potential
solubilizer
enhancers
drugs.
ACS Omega,
Год журнала:
2024,
Номер
9(26), С. 28937 - 28950
Опубликована: Июнь 15, 2024
We
have
developed
a
highly
efficient
technique
of
magnetically
controlled
swift
loading
and
release
doxorubicin
(DOX)
drug
using
magnetoelectric
nanogenerator
(MENG).
Core–shell
nanostructured
MENG
with
magnetostrictive
core
piezoelectric
shell
act
as
field-responsive
nanocarriers
possess
the
capability
field-triggered
in
cancerous
environment.
MENGs
generate
surface
electric
dipole
when
subjected
to
magnetic
field
due
strain-mediated
effect.
The
directional
field-assisted
modulation
electrical
provides
mechanism
create/break
ionic
bonds
DOX
molecules,
which
facilitates
attachment
on-demand
detachment
at
targeted
site.
drug-loading
was
minutely
analyzed
spectrophotometry
Raman
spectroscopy.
detailed
time-dependent
analysis
by
under
unidirectional
rotating
excitation
conducted
field-emission
scanning
electron
microscopy,
energy-dispersive
X-ray,
atomic
force
microscopic
measurements.
In
vitro,
experiments
validate
cytocompatibility
assisted
delivery
near
MCF-7
breast
cancer
cells,
results
significant
enhancement
cell
killing
efficiency.
A
state-of-the-art
experiment
performed
visualize
nanoscale
effect
off-axis
holography
Lorentz
conditions.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 29, 2024
Abstract
Ionic
liquids
(ILs)
are
salts
with
melting
points
typically
<100
°C,
composed
of
specific
anions
and
cations.
Recently,
IL
application
has
expanded
into
material
engineering
biomedicine.
Due
to
their
unique
properties,
ILs
have
garnered
significant
interest
in
pharmacological
research
as
solubilizers,
transdermal
absorption
enhancers,
antibacterial
agents,
stabilizers
insoluble
pharmaceutical
active
ingredients.
The
improvement
skin
permeability
by
is
closely
associated
physicochemical
characteristics,
which
identified
ionic
composition.
However,
the
existing
literature
on
medication
administration
insufficient
terms
a
comprehensive
knowledge
base.
This
review
provides
assessment
design
principles
involved
synthesis.
Additionally,
it
discusses
methods
utilized
assess
focused
outline
drug
administration.
