Breaking Through Physiological Barriers: Nanorobotic Strategies for Active Drug Delivery DOI
Meng Mao, Yingjie Wu, Qiang He

и другие.

Bioconjugate Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

Self-propelled micro/nanomotors (MNMs) represent a groundbreaking advancement in precision drug delivery, offering potential solutions to persistent challenges such as systemic toxicity, limited bioavailability, and nonspecific distribution. By transforming various energy sources into mechanical motion, MNMs are able autonomously navigate through complex physiological environments, facilitating targeted delivery of therapeutic agents previously inaccessible regions. However, achieve efficient vivo biomedical must demonstrate their ability overcome crucial barriers encompassing mucosal surfaces, blood flow dynamics, vascular endothelium, cellular membrane. This review provides comprehensive overview the latest strategies developed address these obstacles while also analyzing broader opportunities associated with clinical translation. Our objective is establish solid foundation for future research medical by focusing on enhancing efficiency advancing medicine, ultimately paving way practical theragnostic applications wider adoption.

Язык: Английский

Particle manipulation under X-force fields DOI
Chun‐Dong Xue,

Yifan Yin,

Xiaoyu Xu

и другие.

Lab on a Chip, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review highlights recent technological advances for progress in particle manipulation under X-force fields, and forecasts the trajectory of future developments.

Язык: Английский

Процитировано

2

Promising advances in physically propelled micro/nanoscale robots DOI Creative Commons

Zishang Liang,

Baolei Zhang, Shenghui Yi

и другие.

Nano Materials Science, Год журнала: 2024, Номер unknown

Опубликована: Июнь 1, 2024

Micro/nanoscale robots (MNRs) have attracted significant interest in various fields because of their flexible design, physically controlled maneuvering, and barrier targeting. The execution specific functions using MNRs relies on precise propulsion methods. Among the diverse techniques, physical is widely used owing to its noninvasive, safe, convenient attributes. This review provides an analysis mechanisms magnetic, electric, thermal, ultrasound presents a comprehensive summary structures, movements, applications while also examining advantages shortcomings associated with Finally, challenges perspectives future development are presented. content this can serve as multidisciplinary science reference for physicists, bioengineers, clinicians, roboticists, chemists involved pharmaceutical design clinical therapy research.

Язык: Английский

Процитировано

4

Function of vitamin D3-loaded lipid-based nanocarriers in food industry: Principles, applications, and challenges DOI
Mohammad Molaveisi, Zhao Ya, Qilong Shi

и другие.

Trends in Food Science & Technology, Год журнала: 2024, Номер unknown, С. 104798 - 104798

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

4

From theory to application: Exploring the motion dynamics of microrobots DOI

Samira Soorani,

Morteza Bayareh

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112846 - 112846

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Micro- and Nanomotors: Engineered Tools for Targeted and Efficient Biomedicine DOI Creative Commons
Noelia Ruiz‐González, David Esporrín‐Ubieto, Il‐Doo Kim

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Over the past two decades, nanotechnology has made significant progress toward development and applications of micromotors (MMs) nanomotors (NMs). Characterized by their capability to self-propel swim in fluids, they have emerged as promising tools various fields, particularly biomedicine. This Review presents an overview current state MMs NMs, motion viscous media complex environments, interaction with biological barriers, potential therapeutical applications. We identify choice appropriate administration routes reach target location a key aspect success NMs biomedical Looking ahead, we envision playing role treating diverse medical disorders, recent proof-of-concept vivo studies demonstrate distinct capabilities versatility. However, addressing regulatory, scalability, biocompatibility, safety concerns remains imperative for successful translation into clinical trials industrial-scale production. work provides guideline researchers, guiding them through landscape, challenges, prospects using biomedicine, thereby encouraging responsible positioning future nanomedicine. Furthermore, outline critical areas further research, including on safety, methods overcome physical obstacles.

Язык: Английский

Процитировано

0

Ultrasound-powered piezocatalytic nanomotors with dual-mode synergistic/cascade propulsion reprogram hypoxic tumor-associated macrophages for enhanced cancer immunotherapy DOI
Ke Ma, Jun-Liang Dong,

Zelong Chen

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162107 - 162107

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Reconfigurable Transport and Assembly of Colloidal Particles via Opto-Chemical-Electronic Tweezer (OCET) DOI
Xi Chen, Shifang Duan,

Dezhou Cao

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Transporting and assembling colloidal particles is key to applications such as drug delivery, the fabrication of functional materials, microrobotics. As a result, there intense effort in developing techniques for manipulating colloids at high spatial temporal resolutions, dynamic, reconfigurable manner. Although optical manipulation provides precise particle control, its application often limited by energy requirements intricate setups. In this study, we present an opto-chemical-electronic tweezer (OCET), novel strategy that addresses these limitations. The OCET system utilizes photocatalytic TiO2/Pt film irradiated with perpendicular UV light. An electric field then generated parallel boundary patterned light, directed from illuminated region dark region. consequent electrophoresis electroosmosis work tandem move inert (e.g., SiO2 microspheres) ∼1 μm/s trap them few μm inside along light pattern. By dynamically modulating patterns, achieves directional transport assembly into arbitrary patterns. holds promise optofluidics, micro/nanorobotics, biomedical systems, setting stage further advancements technologies.

Язык: Английский

Процитировано

0

Light controllable smart Poly(ADP-ribose) polymerase-1 inhibitor delivery by sustainable green materials for regulation of cytotoxicity DOI

Guldan Nazarbek,

Zhuldyz Omarova,

Ainur Shaimoldina

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 107036 - 107036

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Dual‐Energy Integration in Photoresponsive Micro/Nanomotors: From Strategic Design to Biomedical Applications DOI Creative Commons
Yufen Chen, João Marcos Gonçalves, Rebeca Ferrer Campos

и другие.

Small, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Abstract Micro/nanomotors (MNMs) are highly versatile small‐scale devices capable of converting external energy inputs into active motion. Among the various sources, light stands out due to its abundance and ability provide spatiotemporal control. However, effectiveness light‐driven motion in complex environments, such as biological tissues or turbid water, is often limited by scattering reduced penetration. To overcome these challenges, recent innovations have integrated light‐based actuation with other stimuli—such magnetic, acoustic, electrical fields—broadening functional range control MNMs. This review highlights cutting‐edge developments dual‐energy powered MNMs, emphasizing examples where paired secondary sources for enhanced propulsion task performance. Furthermore, insights offered fabrication techniques, biomedical applications, future directions hybrid while addressing remaining challenges this rapidly evolving field.

Язык: Английский

Процитировано

2

Breaking Through Physiological Barriers: Nanorobotic Strategies for Active Drug Delivery DOI
Meng Mao, Yingjie Wu, Qiang He

и другие.

Bioconjugate Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

Self-propelled micro/nanomotors (MNMs) represent a groundbreaking advancement in precision drug delivery, offering potential solutions to persistent challenges such as systemic toxicity, limited bioavailability, and nonspecific distribution. By transforming various energy sources into mechanical motion, MNMs are able autonomously navigate through complex physiological environments, facilitating targeted delivery of therapeutic agents previously inaccessible regions. However, achieve efficient vivo biomedical must demonstrate their ability overcome crucial barriers encompassing mucosal surfaces, blood flow dynamics, vascular endothelium, cellular membrane. This review provides comprehensive overview the latest strategies developed address these obstacles while also analyzing broader opportunities associated with clinical translation. Our objective is establish solid foundation for future research medical by focusing on enhancing efficiency advancing medicine, ultimately paving way practical theragnostic applications wider adoption.

Язык: Английский

Процитировано

1