Breaking Through Physiological Barriers: Nanorobotic Strategies for Active Drug Delivery DOI
Meng Mao, Yingjie Wu, Qiang He

et al.

Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Self-propelled micro/nanomotors (MNMs) represent a groundbreaking advancement in precision drug delivery, offering potential solutions to persistent challenges such as systemic toxicity, limited bioavailability, and nonspecific distribution. By transforming various energy sources into mechanical motion, MNMs are able autonomously navigate through complex physiological environments, facilitating targeted delivery of therapeutic agents previously inaccessible regions. However, achieve efficient vivo biomedical must demonstrate their ability overcome crucial barriers encompassing mucosal surfaces, blood flow dynamics, vascular endothelium, cellular membrane. This review provides comprehensive overview the latest strategies developed address these obstacles while also analyzing broader opportunities associated with clinical translation. Our objective is establish solid foundation for future research medical by focusing on enhancing efficiency advancing medicine, ultimately paving way practical theragnostic applications wider adoption.

Language: Английский

Promising advances in physically propelled micro/nanoscale robots DOI Creative Commons

Zishang Liang,

Baolei Zhang, Shenghui Yi

et al.

Nano Materials Science, Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Micro/nanoscale robots (MNRs) have attracted significant interest in various fields because of their flexible design, physically controlled maneuvering, and barrier targeting. The execution specific functions using MNRs relies on precise propulsion methods. Among the diverse techniques, physical is widely used owing to its noninvasive, safe, convenient attributes. This review provides an analysis mechanisms magnetic, electric, thermal, ultrasound presents a comprehensive summary structures, movements, applications while also examining advantages shortcomings associated with Finally, challenges perspectives future development are presented. content this can serve as multidisciplinary science reference for physicists, bioengineers, clinicians, roboticists, chemists involved pharmaceutical design clinical therapy research.

Language: Английский

Citations

4
Particle manipulation under X-force fields DOI
Chun‐Dong Xue,

Yifan Yin,

Xiaoyu Xu

et al.

Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review highlights recent technological advances for progress in particle manipulation under X-force fields, and forecasts the trajectory of future developments.

Language: Английский

Citations

0
From theory to application: Exploring the motion dynamics of microrobots DOI

Samira Soorani,

Morteza Bayareh

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112846 - 112846

Published: Jan. 1, 2025

Language: Английский

Citations

0
Reconfigurable Transport and Assembly of Colloidal Particles via Opto-Chemical-Electronic Tweezer (OCET) DOI
Xi Chen, Shifang Duan,

Dezhou Cao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Transporting and assembling colloidal particles is key to applications such as drug delivery, the fabrication of functional materials, microrobotics. As a result, there intense effort in developing techniques for manipulating colloids at high spatial temporal resolutions, dynamic, reconfigurable manner. Although optical manipulation provides precise particle control, its application often limited by energy requirements intricate setups. In this study, we present an opto-chemical-electronic tweezer (OCET), novel strategy that addresses these limitations. The OCET system utilizes photocatalytic TiO2/Pt film irradiated with perpendicular UV light. An electric field then generated parallel boundary patterned light, directed from illuminated region dark region. consequent electrophoresis electroosmosis work tandem move inert (e.g., SiO2 microspheres) ∼1 μm/s trap them few μm inside along light pattern. By dynamically modulating patterns, achieves directional transport assembly into arbitrary patterns. holds promise optofluidics, micro/nanorobotics, biomedical systems, setting stage further advancements technologies.

Language: Английский

Citations

0
Micro- and Nanomotors: Engineered Tools for Targeted and Efficient Biomedicine DOI Creative Commons
Noelia Ruiz‐González, David Esporrín‐Ubieto, Il‐Doo Kim

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Over the past two decades, nanotechnology has made significant progress toward development and applications of micromotors (MMs) nanomotors (NMs). Characterized by their capability to self-propel swim in fluids, they have emerged as promising tools various fields, particularly biomedicine. This Review presents an overview current state MMs NMs, motion viscous media complex environments, interaction with biological barriers, potential therapeutical applications. We identify choice appropriate administration routes reach target location a key aspect success NMs biomedical Looking ahead, we envision playing role treating diverse medical disorders, recent proof-of-concept vivo studies demonstrate distinct capabilities versatility. However, addressing regulatory, scalability, biocompatibility, safety concerns remains imperative for successful translation into clinical trials industrial-scale production. work provides guideline researchers, guiding them through landscape, challenges, prospects using biomedicine, thereby encouraging responsible positioning future nanomedicine. Furthermore, outline critical areas further research, including on safety, methods overcome physical obstacles.

Language: Английский

Citations

0
Ultrasound-powered piezocatalytic nanomotors with dual-mode synergistic/cascade propulsion reprogram hypoxic tumor-associated macrophages for enhanced cancer immunotherapy DOI
Ke Ma, Jun-Liang Dong,

Zelong Chen

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162107 - 162107

Published: April 1, 2025

Language: Английский

Citations

0
Function of vitamin D3-loaded lipid-based nanocarriers in food industry: Principles, applications, and challenges DOI
Mohammad Molaveisi, Zhao Ya, Qilong Shi

et al.

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: unknown, P. 104798 - 104798

Published: Nov. 1, 2024

Language: Английский

Citations

3
Dual‐Energy Integration in Photoresponsive Micro/Nanomotors: From Strategic Design to Biomedical Applications DOI Creative Commons
Yufen Chen, João Marcos Gonçalves, Rebeca Ferrer Campos

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract Micro/nanomotors (MNMs) are highly versatile small‐scale devices capable of converting external energy inputs into active motion. Among the various sources, light stands out due to its abundance and ability provide spatiotemporal control. However, effectiveness light‐driven motion in complex environments, such as biological tissues or turbid water, is often limited by scattering reduced penetration. To overcome these challenges, recent innovations have integrated light‐based actuation with other stimuli—such magnetic, acoustic, electrical fields—broadening functional range control MNMs. This review highlights cutting‐edge developments dual‐energy powered MNMs, emphasizing examples where paired secondary sources for enhanced propulsion task performance. Furthermore, insights offered fabrication techniques, biomedical applications, future directions hybrid while addressing remaining challenges this rapidly evolving field.

Language: Английский

Citations

1
Breaking Through Physiological Barriers: Nanorobotic Strategies for Active Drug Delivery DOI
Meng Mao, Yingjie Wu, Qiang He

et al.

Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Self-propelled micro/nanomotors (MNMs) represent a groundbreaking advancement in precision drug delivery, offering potential solutions to persistent challenges such as systemic toxicity, limited bioavailability, and nonspecific distribution. By transforming various energy sources into mechanical motion, MNMs are able autonomously navigate through complex physiological environments, facilitating targeted delivery of therapeutic agents previously inaccessible regions. However, achieve efficient vivo biomedical must demonstrate their ability overcome crucial barriers encompassing mucosal surfaces, blood flow dynamics, vascular endothelium, cellular membrane. This review provides comprehensive overview the latest strategies developed address these obstacles while also analyzing broader opportunities associated with clinical translation. Our objective is establish solid foundation for future research medical by focusing on enhancing efficiency advancing medicine, ultimately paving way practical theragnostic applications wider adoption.

Language: Английский

Citations

1