Biotechnology Journal,
Год журнала:
2024,
Номер
19(12)
Опубликована: Дек. 1, 2024
ABSTRACT
Ultrasound
(US)
can
easily
penetrate
media
with
excellent
spatial
precision
corresponding
to
its
wavelength.
Naturally,
US
plays
a
pivotal
role
in
the
echolocation
abilities
of
certain
mammals
such
as
bats
and
dolphins.
In
addition,
medical
generated
by
transducers
interact
tissues
via
delivering
ultrasonic
energy
modes
heat
generation,
exertion
acoustic
radiation
force
(ARF),
cavitation.
Based
on
principle
echolocation,
various
assistive
devices
for
visual
impairment
people
have
been
developed.
High‐Intensity
Focused
(HIFU)
are
developed
targeted
ablation
tissue
destruction.
Besides
thermal
ablation,
histotripsy
is
designed
damage
purely
mechanical
effect
without
coagulation.
Low‐Intensity
(LIFU)
has
proven
be
an
effective
stimulation
method
neuromodulation.
Furthermore,
reported
transiently
increase
permeability
biological
membranes,
enabling
transfection
blood‐brain
barrier
open.
All
these
advances
changing
clinic.
This
review
mainly
introduces
aspects,
focusing
physical
principles,
challenges,
future
direction.
Molecules,
Год журнала:
2025,
Номер
30(3), С. 542 - 542
Опубликована: Янв. 24, 2025
The
CRISPR-Cas9
technology,
one
of
the
groundbreaking
genome
editing
methods
for
addressing
genetic
disorders,
has
emerged
as
a
powerful,
precise,
and
efficient
tool.
However,
its
clinical
translation
remains
hindered
by
challenges
in
delivery
efficiency
targeting
specificity.
This
review
provides
comprehensive
analysis
structural
features,
advantages,
potential
applications
various
non-viral
stimuli-responsive
systems,
examining
recent
progress
to
emphasize
address
these
limitations
advance
therapeutics.
We
describe
how
reports
that
nonviral
vectors,
including
lipid-based
nanoparticles,
extracellular
vesicles,
polymeric
gold
mesoporous
silica
can
offer
diverse
advantages
enhance
stability,
cellular
uptake,
biocompatibility,
based
on
their
structures
physio-chemical
stability.
also
summarize
nanoformulations,
type
vector,
introduce
precision
control
delivery.
Stimuli-responsive
nanoformulations
are
designed
respond
pH,
redox
states,
external
triggers,
facilitate
controlled
targeted
delivery,
minimize
off-target
effects.
insights
our
suggest
future
gene
therapy
technologies
highlight
systems
CRISPR-Cas9’s
efficacy,
positioning
them
pivotal
tools
gene-editing
therapies.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 3, 2025
Sound
signals
not
only
serve
as
the
primary
communication
medium
but
also
find
application
in
fields
such
medical
diagnosis
and
fault
detection.
With
public
healthcare
resources
increasingly
under
pressure,
challenges
faced
by
disabled
individuals
on
a
daily
basis,
solutions
that
facilitate
low-cost
private
hold
considerable
promise.
Acoustic
methods
have
been
widely
studied
because
of
their
lower
technical
complexity
compared
to
other
solutions,
well
high
safety
threshold
human
body
acoustic
energy.
Furthermore,
with
recent
development
artificial
intelligence
technology
applied
speech
recognition,
recognition
devices,
systems
capable
assisting
interacting
scenes
are
constantly
being
updated.
This
review
meticulously
summarizes
sensing
mechanisms,
materials,
structural
design,
multidisciplinary
applications
wearable
devices
health
human-computer
interaction.
Further,
advantages
disadvantages
different
approaches
used
flexible
various
examined.
Finally,
current
roadmap
for
future
research
analyzed
based
existing
progress
achieve
more
comprehensive
personalized
healthcare.
Pharmaceutics,
Год журнала:
2024,
Номер
16(9), С. 1181 - 1181
Опубликована: Сен. 7, 2024
The
programmed
death-1/programmed
death-ligand
1
(PD-1/PD-L1)
immune
checkpoint
constitutes
an
inhibitory
pathway
best
known
for
its
regulation
of
cluster
differentiation
8
(CD8)+
T
cell-mediated
responses.
Engagement
PD-L1
with
PD-1
expressed
on
CD8+
cells
activates
downstream
signaling
pathways
that
culminate
in
cell
exhaustion
and/or
apoptosis.
Physiologically,
these
immunosuppressive
effects
exist
to
prevent
autoimmunity,
but
cancer
exploit
this
by
overexpressing
facilitate
escape.
Intravenously
(IV)
administered
inhibitors
(ICIs)
block
the
interaction
between
PD-1/PD-L1
have
achieved
great
success
reversing
and
promoting
tumor
regression
various
malignancies.
However,
ICIs
can
cause
immune-related
adverse
events
(irAEs)
due
off-tumor
toxicities
which
limits
their
therapeutic
potential.
Therefore,
considerable
effort
has
been
channeled
into
exploring
alternative
delivery
strategies
enhance
tumor-directed
reduce
irAEs.
Here,
we
briefly
describe
PD-1/PD-L1-targeted
immunotherapy
associated
We
then
provide
a
detailed
review
approaches,
including
locoregional
(LDD)-,
oncolytic
virus
(OV)-,
nanoparticle
(NP)-,
ultrasound
microbubble
(USMB)-mediated
are
currently
under
investigation
enhancing
tumor-specific
minimize
toxic
effects.
conclude
commentary
key
challenges
methods
potential
mitigate
them.
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Nanomedicine
holds
promise
in
the
process
of
diagnosis
and
treatment
settings
neurotoxic
conditions
many
central
nervous
system
(CNS)
disorders,
including
neurodegenerative
diseases
other
non-tumor
herein,
especially
when
using
iron
oxide
nanoparticles
for
imaging
biomarker
development
magnetic
resonance
(MRI)
at
molecular
level.
The
status
perspectives
field
recent
utilization
superparamagnetic
(SPIOs)
and/or
ultra-small
(USPIOs)
theranostics
evaluation
are
introduced,
focusing
on
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
others
based
Aß
cascade
hypothesis
oligomeric
amyloid
as
well
hyperphosphorylated
tau
fibrils
leading
to
neurotoxicity
AD,
propagation
misfolded
α-synuclein
PD,
mechanism
CNS
neuroinflammation.
In
this
chapter,
we
demonstrate
role
nano-theranostic
agents
neuroimaging
with
MR
scans
diseases,
stroke,
traumatic
brain
injury
(TBI),
diseases.
Some
methods
doing
analysis
data
provided.
introduction
fundamental
nanoparticle-initiated
would
seem
out
aim
our
description.
